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MAP3K10 mitogen-activated protein kinase kinase kinase 10 [ Homo sapiens (human) ]

Gene ID: 4294, updated on 5-Mar-2024

Summary

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Official Symbol
MAP3K10provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 10provided by HGNC
Primary source
HGNC:HGNC:6849
See related
Ensembl:ENSG00000130758 MIM:600137; AllianceGenome:HGNC:6849
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MST; MLK2; MEKK10
Summary
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 11.1), testis (RPKM 4.1) and 24 other tissues See more
Orthologs
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Genomic context

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See MAP3K10 in Genome Data Viewer
Location:
19q13.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (40191426..40215575)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (43011933..43036086)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40697333..40721482)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904803 Neighboring gene MPRA-validated peak3482 silencer Neighboring gene vomeronasal 1 receptor 96 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14639 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14640 Neighboring gene Sharpr-MPRA regulatory region 5792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14641 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10616 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10617 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:40711899-40712419 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:40723159-40723749 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:40725328-40726527 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:40729726-40730925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40732430-40732983 Neighboring gene tetratricopeptide repeat domain 9B Neighboring gene cyclin P

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DNA methylation of the MAP3K10 gene may participate in the development of intracranial aneurysm. Zhao J, et al. Gene, 2023 Jan 30. PMID 36341729
  2. Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2. Hirai S, et al. J Biol Chem, 1998 Mar 27. PMID 9516438
  3. Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain. Katoh M, et al. Oncogene, 1995 Apr 6. PMID 7731697
  4. DNA methylation‑regulated miR‑155‑5p depresses sensitivity of esophageal carcinoma cells to radiation and multiple chemotherapeutic drugs via suppression of MAP3K10. Luo W, et al. Oncol Rep, 2020 May. PMID 32323857
  5. MicroRNA-155 targets MAP3K10 and regulates osteosarcoma cell growth. Wang C, et al. Pathol Res Pract, 2017 Apr. PMID 28214207

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNA methylation of the MAP3K10 gene may participate in the development of intracranial aneurysm.
    Title: DNA methylation of the MAP3K10 gene may participate in the development of intracranial aneurysm.
  2. DNA methylationregulated miR1555p depresses sensitivity of esophageal carcinoma cells to radiation and multiple chemotherapeutic drugs via suppression of MAP3K10.
    Title: DNA methylation‑regulated miR‑155‑5p depresses sensitivity of esophageal carcinoma cells to radiation and multiple chemotherapeutic drugs via suppression of MAP3K10.
  3. MST interaction with MOB1 is not essential for development and tissue growth control.
    Title: Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control.
  4. We identified a direct target of miR-155 as MAP3K10 in osteosarcoma
    Title: MicroRNA-155 targets MAP3K10 and regulates osteosarcoma cell growth.
  5. MAP3K4 is sufficiently mediate the TGFbeta-induced phosphorylation of p38 MAPK in MEFs and HaCaT cells.
    Title: The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1.
  6. A novel and important role for MAP3K10 in the proliferation and chemoresistance of pancreatic ductal adenocarcinoma.
    Title: MAP3K10 promotes the proliferation and decreases the sensitivity of pancreatic cancer cells to gemcitabine by upregulating Gli-1 and Gli-2.
  7. This study showed that show that RUNX3 is a principal and evolutionarily conserved component of the MST pathway.
    Title: Identification of RUNX3 as a component of the MST/Hpo signaling pathway.
  8. Mechanism of MAP kinase activation by TNF requires Src-dependent activation of Vav, activation of Rac/Cdc42, and the engagement of the Rac/Cdc42 interaction site on MLK3.
    Title: TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.
  9. Mechanism of MAP kinase activation by TNF requires Src-dependent activation of Vav, activation of Rac/Cdc42, and the engagement of the Rac/Cdc42 interaction site on MLK2 and 3.
    Title: TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.
  10. Data show that miR-181b contributed to proliferation of AML cells by targeting MLK2.
    Title: microRNA-181b targets MLK2 in HL-60 cells.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables JUN kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables JUN kinase kinase kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables bHLH transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in JNK cascade TAS
Traceable Author Statement
more info
 PubMed 
involved_in apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 10
Names
MKN28 derived nonreceptor_type serine/threonine kinase
MKN28 kinase
mixed lineage kinase 2
protein kinase MST
NP_002437.2
XP_011525283.1
XP_011525284.1
XP_047294800.1
XP_047294801.1
XP_054177013.1
XP_054177014.1
XP_054177015.1
XP_054177016.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002446.4 → NP_002437.2  mitogen-activated protein kinase kinase kinase 10

    See identical proteins and their annotated locations for NP_002437.2

    Status: REVIEWED

    Source sequence(s)
    AC011496, BF594729, BU633407, X90846, Z48615
    Consensus CDS
    CCDS12549.1
    UniProtKB/Swiss-Prot
    Q02779, Q12761, Q14871
    Related
    ENSP00000253055.2, ENST00000253055.8
    Conserved Domains (3) summary
    smart00219
    Location:98 → 357
    TyrKc; Tyrosine kinase, catalytic domain
    cd12059
    Location:20 → 76
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cd14148
    Location:103 → 360
    STKc_MLK2; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    40191426..40215575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526981.3 → XP_011525283.1  mitogen-activated protein kinase kinase kinase 10 isoform X1

    Conserved Domains (3) summary
    smart00219
    Location:98 → 365
    TyrKc; Tyrosine kinase, catalytic domain
    cd12059
    Location:20 → 76
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cl21453
    Location:103 → 368
    PKc_like; Protein Kinases, catalytic domain

  2. XM_011526982.4 → XP_011525284.1  mitogen-activated protein kinase kinase kinase 10 isoform X2

    Conserved Domains (3) summary
    smart00219
    Location:98 → 365
    TyrKc; Tyrosine kinase, catalytic domain
    cd12059
    Location:20 → 76
    SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
    cl21453
    Location:103 → 368
    PKc_like; Protein Kinases, catalytic domain

  3. XM_047438844.1 → XP_047294800.1  mitogen-activated protein kinase kinase kinase 10 isoform X3

  4. XM_047438845.1 → XP_047294801.1  mitogen-activated protein kinase kinase kinase 10 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    43011933..43036086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321038.1 → XP_054177013.1  mitogen-activated protein kinase kinase kinase 10 isoform X1

  2. XM_054321039.1 → XP_054177014.1  mitogen-activated protein kinase kinase kinase 10 isoform X2

  3. XM_054321040.1 → XP_054177015.1  mitogen-activated protein kinase kinase kinase 10 isoform X3

  4. XM_054321041.1 → XP_054177016.1  mitogen-activated protein kinase kinase kinase 10 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02779.3 GenPept UniProtKB/Swiss-Prot:Q02779

Gene LinkOut

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