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bambib BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b [ Danio rerio (zebrafish) ]

Gene ID: 431736, updated on 27-Mar-2024

Summary

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Official Symbol
bambibprovided by ZNC
Official Full Name
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040704-30
See related
Ensembl:ENSDARG00000099677 AllianceGenome:ZFIN:ZDB-GENE-040704-30
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:91871
Summary
Predicted to enable frizzled binding activity. Predicted to be involved in transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway and positive regulation of canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including ectoderm; epidermis; optic vesicle; pectoral fin; and pectoral fin bud. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human BAMBI (BMP and activin membrane bound inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 2
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (4402765..4408829)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (4562140..4568204)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene Cdk5 and Abl enzyme substrate 1 Neighboring gene WW domain containing adaptor with coiled-coil b Neighboring gene adiponectin, C1Q and collagen domain containing, b Neighboring gene uncharacterized LOC101886376 Neighboring gene teleost multiple tissue opsin a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A BMP regulatory network controls ectodermal cell fate decisions at the neural plate border. Reichert S, et al. Development, 2013 Nov. PMID 24089471
  2. Single-cell transcriptomic analysis of vascular endothelial cells in zebrafish embryos. Gurung S, et al. Sci Rep, 2022 Jul 29. PMID 35906287, Free PMC Article
  3. BMP Signaling Interferes with Optic Chiasm Formation and Retinal Ganglion Cell Pathfinding in Zebrafish. Knickmeyer MD, et al. Int J Mol Sci, 2021 Apr 27. PMID 33925390, Free PMC Article
  4. Wnt/β-catenin signaling defines organizing centers that orchestrate growth and differentiation of the regenerating zebrafish caudal fin. Wehner D, et al. Cell Rep, 2014 Feb 13. PMID 24485658
  5. Time point-based integrative analyses of deep-transcriptome identify four signal pathways in blastemal regeneration of zebrafish lower jaw. Zhang H, et al. Stem Cells, 2015 Mar. PMID 25420467

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002189.1 → NP_001002189.1  BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b precursor

    See identical proteins and their annotated locations for NP_001002189.1

    Status: PROVISIONAL

    Source sequence(s)
    BC072715
    UniProtKB/TrEMBL
    B2GRX2, Q6GQM7
    Related
    ENSDARP00000140083.1, ENSDART00000159525.2
    Conserved Domains (1) summary
    pfam06211
    Location:4 → 110
    BAMBI; BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    4402765..4408829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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