Lerp lysosomal enzyme receptor protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Lerpprovided by FlyBase
Official Full Name: lysosomal enzyme receptor proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0051072
Locus tag: Dmel_CG31072
See related: AllianceGenome:FB:FBgn0051072
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.383; CG14255; CG14256; CG31072; CG6390; CG6396; Dmel\CG31072; LERP
Summary: Predicted to enable mannose binding activity and signaling receptor activity. Involved in lysosomal transport; positive regulation of autophagy; and post-Golgi vesicle-mediated transport. Located in clathrin-coated vesicle; perinuclear region of cytoplasm; and trans-Golgi network. Is expressed in adult head. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); hepatocellular carcinoma; in situ carcinoma (multiple); and nephroblastoma. Orthologous to human IGF2R (insulin like growth factor 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (26842462..26863130, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (22668184..22688852, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

LERP has a role in biogenesis of Drosophila lysosomes.
Title: The novel Drosophila lysosomal enzyme receptor protein mediates lysosomal sorting in mammalian cells and binds mammalian and Drosophila GGA adaptors.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables insulin-like growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables mannose binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lysosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in lysosomal transport	IDA Inferred from Direct Assay more info	PubMed
involved_in lysosomal transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-Golgi vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IC Inferred by Curator more info	PubMed
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

Names: CG31072-PA; CG31072-PB; CG31072-PD; CG31072-PE; Lerp-PA; Lerp-PB; Lerp-PD; Lerp-PE

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