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OR4Q3 olfactory receptor family 4 subfamily Q member 3 [ Homo sapiens (human) ]

Gene ID: 441669, updated on 11-Apr-2024

Summary

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Official Symbol
OR4Q3provided by HGNC
Official Full Name
olfactory receptor family 4 subfamily Q member 3provided by HGNC
Primary source
HGNC:HGNC:15426
See related
Ensembl:ENSG00000182652 AllianceGenome:HGNC:15426
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSA6; OR4Q4; OR14-3; C14orf13; c14_5008
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Annotation information
Annotation category: partial on reference assembly
Orthologs
mouse all
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Genomic context

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See OR4Q3 in Genome Data Viewer
Location:
14q11.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (19743571..19752334)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (13918508..13962426)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (20215587..20216528)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 11 subfamily H member 2 Neighboring gene olfactory receptor family 11 subfamily K member 2 pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene olfactory receptor family 4 subfamily H member 12 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. Rouquier S, et al. Proc Natl Acad Sci U S A, 2000 Mar 14. PMID 10706615, Free PMC Article
  2. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
  3. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
olfactory receptor 4Q3
Names
olfactory receptor 4Q4
olfactory receptor OR14-3
olfactory receptor, family 4, subfamily Q, member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405963.1 → NP_001392892.1  olfactory receptor 4Q3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL512310, KF455839
    UniProtKB/TrEMBL
    A0A2U3TZU4
    Related
    ENSP00000492928.2, ENST00000642117.2

  2. NM_172194.1 → NP_751944.1  olfactory receptor 4Q3 isoform 1

    See identical proteins and their annotated locations for NP_751944.1

    Status: VALIDATED

    Source sequence(s)
    AB065609
    UniProtKB/Swiss-Prot
    Q6IEX4, Q8NH05
    UniProtKB/TrEMBL
    A0A126GW32
    Conserved Domains (2) summary
    pfam00001
    Location:41 → 288
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:35 → 302
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    19743571..19752334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449618.1 → XP_024305386.1  olfactory receptor 4Q3 isoform X1

    Conserved Domains (1) summary
    cd15935
    Location:98 → 355
    7tmA_OR4Q3-like; olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    13918508..13962426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376145.1 → XP_054232120.1  olfactory receptor 4Q3 isoform X2

    UniProtKB/TrEMBL
    A0A126GWJ8

RNA

  1. XR_007085115.1 RNA Sequence

  2. XR_007085116.1 RNA Sequence

  3. XR_007085117.1 RNA Sequence

  4. XR_007085119.1 RNA Sequence

  5. XR_007085118.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NH05.1 GenPept UniProtKB/Swiss-Prot:Q8NH05

Gene LinkOut

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Chemical Information
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