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hadh hydroxyacyl-CoA dehydrogenase [ Danio rerio (zebrafish) ]

Gene ID: 445121, updated on 27-Mar-2024

Summary

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Official Symbol
hadhprovided by ZNC
Official Full Name
hydroxyacyl-CoA dehydrogenaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040801-261
See related
Ensembl:ENSDARG00000030765 AllianceGenome:ZFIN:ZDB-GENE-040801-261
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hoad; hadhsc; zgc:86777; wu:fb66a11
Summary
Predicted to enable 3-hydroxyacyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be active in mitochondrion. Is expressed in liver. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 4. Orthologous to human HADH (hydroxyacyl-CoA dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See hadh in Genome Data Viewer
Location:
chromosome: 1
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (49909672..49918867, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (49265846..49275041, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene cracd like b Neighboring gene lymphoid enhancer-binding factor 1 Neighboring gene cytochrome P450, family 2, subfamily U, polypeptide 1 Neighboring gene sphingomyelin synthase 2a Neighboring gene glutathione S-transferase, C-terminal domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Effects of chronic dietary selenomethionine exposure on repeat swimming performance, aerobic metabolism and methionine catabolism in adult zebrafish (Danio rerio). Thomas JK, et al. Aquat Toxicol, 2013 Apr 15. PMID 23399444
  2. Cardiac and Metabolic Effects of Dietary Selenomethionine Exposure in Adult Zebrafish. Pettem CM, et al. Toxicol Sci, 2017 Oct 1. PMID 28962524
  3. Temperature- and exercise-induced gene expression and metabolic enzyme changes in skeletal muscle of adult zebrafish (Danio rerio). McClelland GB, et al. J Physiol, 2006 Dec 1. PMID 16990399, Free PMC Article
  4. Metabolic consequences of PGC-1α dysregulation in adult zebrafish muscle. Kurchaba N, et al. Am J Physiol Regul Integr Comp Physiol, 2022 Sep 1. PMID 35670765
  5. Single and joint toxic effects of four antibiotics on some metabolic pathways of zebrafish (Danio rerio) larvae. Qiu W, et al. Sci Total Environ, 2020 May 10. PMID 32036144

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-hydroxyacyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Names
L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain
hydroxyacyl-Coenzyme A dehydrogenase
NP_001003515.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003515.1 → NP_001003515.1  hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

    See identical proteins and their annotated locations for NP_001003515.1

    Status: PROVISIONAL

    Source sequence(s)
    BC075768
    UniProtKB/TrEMBL
    A0A8M1N163, Q6DI22
    Related
    ENSDARP00000050602.5, ENSDART00000050603.6
    Conserved Domains (3) summary
    COG1250
    Location:20 → 307
    FadB; 3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]
    pfam00725
    Location:211 → 308
    3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
    pfam02737
    Location:24 → 209
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    49909672..49918867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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