U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

sf3a3 splicing factor 3a, subunit 3 [ Danio rerio (zebrafish) ]

Gene ID: 446168, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
sf3a3provided by ZNC
Official Full Name
splicing factor 3a, subunit 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-040908-1
See related
Ensembl:ENSDARG00000100114 AllianceGenome:ZFIN:ZDB-GENE-040908-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
SAP61; SF3a60; wu:fi15a06; wu:fj94f01; zgc:110227
Summary
Predicted to enable RNA binding activity. Acts upstream of or within hematopoietic stem cell differentiation. Predicted to be located in nucleus. Predicted to be part of spliceosomal complex. Orthologous to human SF3A3 (splicing factor 3a subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 19
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (17292667..17304994, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (17388305..17400632, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438143 Neighboring gene mannosidase endo-alpha like Neighboring gene ubiquitin-conjugating enzyme E2E 1 Neighboring gene NFKB inhibitor interacting Ras-like 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Burns CE, et al. Blood, 2009 Jun 4. PMID 19332767, Free PMC Article
  2. A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Trinh le A, et al. Genes Dev, 2011 Nov 1. PMID 22056673, Free PMC Article
  3. New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens. Tseng LC, et al. PLoS One, 2014. PMID 24714733, Free PMC Article
  4. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC110227

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
splicing factor 3A subunit 3
Names
spliceosome associated protein 61

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004289.1 → NP_001004289.1  splicing factor 3A subunit 3

    See identical proteins and their annotated locations for NP_001004289.1

    Status: PROVISIONAL

    Source sequence(s)
    AY648757
    UniProtKB/TrEMBL
    Q6DRK2
    Related
    ENSDARP00000140243.1, ENSDART00000160433.3
    Conserved Domains (5) summary
    COG5188
    Location:2 → 501
    PRP9; Splicing factor 3a, subunit 3 [RNA processing and modification]
    pfam11931
    Location:323 → 498
    DUF3449; Domain of unknown function (DUF3449)
    pfam12108
    Location:74 → 100
    SF3a60_bindingd; Splicing factor SF3a60 binding domain
    pfam13297
    Location:244 → 303
    Telomere_Sde2_2; Telomere stability C-terminal
    pfam16837
    Location:129 → 204
    SF3A3; Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    17292667..17304994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous