tnip1 TNFAIP3 interacting protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tnip1provided by ZNC
Official Full Name: TNFAIP3 interacting protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-070112-1502
See related: Ensembl:ENSDARG00000015653 AllianceGenome:ZFIN:ZDB-GENE-070112-1502
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: naf1; im:7141452; zgc:158159
Summary: Predicted to be involved in cellular response to lipopolysaccharide; negative regulation of I-kappaB kinase/NF-kappaB signaling; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within MyD88-dependent toll-like receptor signaling pathway; negative regulation of ERK1 and ERK2 cascade; and regulation of inflammatory response. Orthologous to human TNIP1 (TNFAIP3 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (49382195..49428025)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (50394438..50440268)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TNFAIP3-interacting protein 1

Names: Nef-associated factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079952.1 → NP_001073421.1 TNFAIP3-interacting protein 1

See identical proteins and their annotated locations for NP_001073421.1

Status: PROVISIONAL

Source sequence(s)

BC129144

UniProtKB/TrEMBL

A1L1N2

Related

ENSDARP00000140148.2, ENSDART00000169441.2

Conserved Domains (2) summary

cl15254
Location:425 → 513

UBAN; polyubiquitin binding domain of NEMO and related proteins

cl19252
Location:219 → 255

MreC; rod shape-determining protein MreC