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CHUK component of inhibitor of nuclear factor kappa B kinase complex [ Pan troglodytes (chimpanzee) ]

Gene ID: 450673, updated on 29-Mar-2024

Summary

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Official Symbol
CHUKprovided by VGNC
Official Full Name
component of inhibitor of nuclear factor kappa B kinase complexprovided by VGNC
Primary source
VGNC:VGNC:1627
Locus tag
CK820_G0004147
See related
Ensembl:ENSPTRG00000033948
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 8 NC_072406.2 (112295118..112338053, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 10 NC_072408.1 (102909545..102952472, complement)

Chromosome 8 - NC_072406.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101059771 Neighboring gene ER lipid raft associated 1 Neighboring gene uncharacterized LOC107966813 Neighboring gene small nucleolar RNA SNORA12 Neighboring gene CWF19 like cell cycle control factor 1 Neighboring gene prohibitin 1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Major chimpanzee-specific structural changes in sperm development-associated genes. Kim RN, et al. Funct Integr Genomics, 2011 Sep. PMID 21484476

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables IkappaB kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of IkappaB kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
inhibitor of nuclear factor kappa-B kinase subunit alpha
Names
SPFH domain-containing protein 1
conserved helix-loop-helix ubiquitous kinase
NP_001267150.1
XP_009457165.1
XP_009457168.1
XP_016817884.1
XP_016817886.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001280221.1 → NP_001267150.1  inhibitor of nuclear factor kappa-B kinase subunit alpha

    See identical proteins and their annotated locations for NP_001267150.1

    Status: PROVISIONAL

    Source sequence(s)
    AK305256
    UniProtKB/TrEMBL
    A0A2I3TGA6, G2HEU2
    Related
    ENSPTRP00000088281.1, ENSPTRT00000077875.1
    Conserved Domains (2) summary
    smart00220
    Location:17 → 269
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14039
    Location:17 → 291
    STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072406.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    112295118..112338053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016962397.4 → XP_016817886.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A2I3T4Q0, A0A2J8PDF0
    Related
    ENSPTRP00000084209.1
    Conserved Domains (1) summary
    cd14039
    Location:21 → 309
    STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha

  2. XM_016962395.4 → XP_016817884.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A2I3T4Q0

  3. XM_009458890.5 → XP_009457165.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2

    See identical proteins and their annotated locations for XP_009457165.1

    UniProtKB/TrEMBL
    A0A2I3T4Q0, A0A2J8PDG6, A0A6D2XTA7, H2RBD4
    Related
    ENSPTRP00000055512.1
    Conserved Domains (2) summary
    cd14039
    Location:21 → 309
    STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha
    pfam12179
    Location:709 → 743
    IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

  4. XM_009458893.5 → XP_009457168.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A2I3T4Q0, A0A2J8PDF0
    Conserved Domains (1) summary
    cd14039
    Location:21 → 309
    STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha

RNA

  1. XR_010159742.1 RNA Sequence

  2. XR_010159743.1 RNA Sequence

  3. XR_010159741.1 RNA Sequence

Nucleotide Protein
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