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MT-CO1 mitochondrially encoded cytochrome c oxidase I [ Homo sapiens (human) ]

Gene ID: 4512, updated on 4-Jan-2025

Summary

Official Symbol
MT-CO1provided by HGNC
Official Full Name
mitochondrially encoded cytochrome c oxidase Iprovided by HGNC
Primary source
HGNC:HGNC:7419
See related
MIM:516030; AllianceGenome:HGNC:7419
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COI; MTCO1; COX1
Summary
Contributes to cytochrome-c oxidase activity. Predicted to be involved in aerobic respiration; positive regulation of vasoconstriction; and respiratory electron transport chain. Located in mitochondrion. Part of mitochondrial membrane and respiratory chain complex IV. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See MT-CO1 in Genome Data Viewer
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) MT (non-nuclear) NC_012920.1 (5904..7445)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) MT (non-nuclear) NC_012920.1 (5904..7445)

Chromosome MT - NC_012920.1Genomic Context describing neighboring genes Neighboring gene tRNA-Cys Neighboring gene tRNA-Tyr Neighboring gene tRNA-Ser Neighboring gene tRNA-Asp

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Tat-induced mitochondrial membrane permeabilization is associated with inhibition of cytochrome c oxidase (COX) activity by Tat in disrupted mitochondria from human samples PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to cytochrome-c oxidase activity  
contributes_to cytochrome-c oxidase activity PubMed 
enables heme binding  
enables metal ion binding  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in aerobic respiration  
involved_in cellular respiration PubMed 
involved_in cerebellum development  
involved_in mitochondrial electron transport, cytochrome c to oxygen PubMed 
involved_in proton transmembrane transport  
involved_in respiratory electron transport chain  
involved_in response to copper ion  
involved_in response to electrical stimulus  
involved_in response to hypoxia  
involved_in response to oxidative stress  
Component Evidence Code Pubs
located_in mitochondrial inner membrane  
located_in mitochondrial membrane PubMed 
located_in mitochondrion PubMed 
part_of respiratory chain complex IV  
part_of respiratory chain complex IV PubMed 
part_of respiratory chain complex IV PubMed 

General protein information

Preferred Names
cytochrome c oxidase subunit I
YP_003024028.1
  • cytochrome c oxidase I

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_012920.1 Reference assembly

    Range
    5904..7445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_003024028.1 cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]

    See identical proteins and their annotated locations for YP_003024028.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P00395, Q34770
    UniProtKB/TrEMBL
    A0A068C201, A0A1J0QWW6, A0A1X7RBG2, A0A343G377, A0S1I7, A1DSF3, A6YV28, A6YYA4, A6YYY8, A6Z6C1, A6ZFK2, B1NTV9, B3GSQ2, B4F437, E7E4V8, F2WJ44, Q4F1M8, Q4GIJ5, Q4VFI9, Q5S9T0, Q6RMP2, Q9B2V2, U5YWV7
    Related
    ENSP00000354499.2
    Conserved Domains (1) summary
    MTH00153
    Location:5507
    COX1; cytochrome c oxidase subunit I; Provisional
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