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NCK2 NCK adaptor protein 2 [ Pan troglodytes (chimpanzee) ]

Gene ID: 459472, updated on 3-Apr-2024

Summary

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Official Symbol
NCK2provided by VGNC
Official Full Name
NCK adaptor protein 2provided by VGNC
Primary source
VGNC:VGNC:305
Locus tag
CK820_G0041219
See related
Ensembl:ENSPTRG00000012316
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2A
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 12 NC_072410.2 (16942699..17093548, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 2A NC_072399.1 (105405443..105556292)

Chromosome 12 - NC_072410.2Genomic Context describing neighboring genes Neighboring gene UDP-glucuronate decarboxylase 1 Neighboring gene chromosome 2A C2orf40 homolog Neighboring gene uncharacterized LOC129143246 Neighboring gene uncharacterized LOC134807789 Neighboring gene uncharacterized LOC134807790

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of PERK-mediated unfolded protein response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of translation in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cytoplasmic protein NCK2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072410.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    16942699..17093548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054678688.1 → XP_054534663.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    A0A2J8K5V9, A0A6D2X2M0, H2QIH7

  2. XM_054678689.1 → XP_054534664.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    A0A2J8K5V9, A0A6D2X2M0, H2QIH7

  3. XM_016949220.4 → XP_016804709.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    A0A2J8K5V9, A0A6D2X2M0, H2QIH7
    Related
    ENSPTRP00000021097.4
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  4. XM_063788921.1 → XP_063644991.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    A0A2J8K5V9, A0A6D2X2M0, H2QIH7

  5. XM_016949222.4 → XP_016804711.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    A0A2J8K5V9, A0A6D2X2M0, H2QIH7
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  6. XM_016949223.4 → XP_016804712.1  cytoplasmic protein NCK2 isoform X2

    UniProtKB/TrEMBL
    A0A2I3TRG5, A0A2J8K5V7
    Conserved Domains (1) summary
    cl17036
    Location:2 → 59
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
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