ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: ATICprovided by VGNC
Official Full Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolaseprovided by VGNC
Primary source: VGNC:VGNC:101
Locus tag: CK820_G0011174
See related: Ensembl:ENSPTRG00000012891
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2B

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	13	NC_072411.2 (117574938..117624078)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	2B	NC_072400.1 (117486102..117540019)

Chromosome 13 - NC_072411.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

WI-10220 (e-PCR)
- UniSTS:29238

RH11837 (e-PCR)
- UniSTS:4204

SGC31824 (e-PCR)
- UniSTS:1735

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables IMP cyclohydrolase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: bifunctional purine biosynthesis protein PURH; bifunctional purine biosynthesis protein ATIC

XP_001150761.2

EC 3.5.4.10

XP_016805940.2

EC 3.5.4.10

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072411.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

117574938..117624078

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001150761.8 → XP_001150761.2 bifunctional purine biosynthesis protein ATIC isoform X2

UniProtKB/TrEMBL

A0A2J8NGZ7, H2R0X5, K7DJN2

Conserved Domains (2) summary

PRK07106
Location:203 → 592

PRK07106; phosphoribosylaminoimidazolecarboxamide formyltransferase

cd01421
Location:5 → 193

IMPCH; Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates ...
XM_016950451.4 → XP_016805940.2 bifunctional purine biosynthesis protein ATIC isoform X1

UniProtKB/TrEMBL

H2R0X5

Conserved Domains (2) summary

PRK07106
Location:203 → 553

PRK07106; 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional

cd01421
Location:5 → 193

IMPCH; Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates ...