CBLB Cbl proto-oncogene B [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: CBLBprovided by VGNC
Official Full Name: Cbl proto-oncogene Bprovided by VGNC
Primary source: VGNC:VGNC:10371
Locus tag: CK820_G0016315
See related: Ensembl:ENSPTRG00000015184
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	2	NC_086015.1 (108970792..109182886, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	3	NC_072401.1 (108880175..109092268, complement)

Chromosome 2 - NC_086015.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

AFMa281wa5 (e-PCR)
- UniSTS:40973

A003P06 (e-PCR)
- UniSTS:3600

G66779 (e-PCR)
- UniSTS:166680

D3S3959 (e-PCR)
- UniSTS:33583

D3S1333E (e-PCR)
- UniSTS:147508

SHGC-77171 (e-PCR)
- UniSTS:45183

SHGC-77174 (e-PCR)
- UniSTS:59526

CBLB_8242 (e-PCR)
- UniSTS:467595

D3S4235 (e-PCR)
- UniSTS:65165

D3S1333E (e-PCR)
- UniSTS:44959

1232 (e-PCR)
- UniSTS:43681

D3S3541 (e-PCR)
- UniSTS:154327

SHGC-35478 (e-PCR)
- UniSTS:1534

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info	PubMed
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of epidermal growth factor-activated receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane raft	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase CBL-B

Names: Cas-Br-M (murine) ecotropic retroviral transforming sequence b; Cbl proto-oncogene B, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase B

XP_003309960.1

EC 2.3.2.27

XP_009444362.1

EC 2.3.2.27

XP_009444363.1

EC 2.3.2.27

XP_009444364.1

EC 2.3.2.27

XP_009444365.1

EC 2.3.2.27

XP_016797076.1

EC 2.3.2.27

XP_016797077.1

EC 2.3.2.27

XP_016797078.1

EC 2.3.2.27

XP_016797079.1

EC 2.3.2.27

XP_016797080.1

EC 2.3.2.27

XP_016797081.1

EC 2.3.2.27

XP_016797082.1

EC 2.3.2.27

XP_054536818.1

EC 2.3.2.27

XP_054536819.1

EC 2.3.2.27

XP_054536820.1

EC 2.3.2.27

XP_054536821.1

EC 2.3.2.27

XP_063662168.1

EC 2.3.2.27

XP_063662169.1

EC 2.3.2.27

XP_063662170.1

EC 2.3.2.27

XP_063662172.1

EC 2.3.2.27

XP_063662173.1

EC 2.3.2.27

XP_063662174.1

EC 2.3.2.27

XP_063662175.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_086015.1 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

108970792..109182886 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_016941587.3 → XP_016797076.1 E3 ubiquitin-protein ligase CBL-B isoform X1

UniProtKB/TrEMBL

A0A2J8MXK0, A0A2J8MXL5, A0A6D2VUE0, H2QN18

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:931 → 971

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
XM_054680843.2 → XP_054536818.1 E3 ubiquitin-protein ligase CBL-B isoform X2

UniProtKB/TrEMBL

A0A2I3S4L5
XM_054680846.2 → XP_054536821.1 E3 ubiquitin-protein ligase CBL-B isoform X4
XM_054680845.2 → XP_054536820.1 E3 ubiquitin-protein ligase CBL-B isoform X3

UniProtKB/TrEMBL

A0A2I3T5A4
XM_016941590.3 → XP_016797079.1 E3 ubiquitin-protein ligase CBL-B isoform X4

UniProtKB/TrEMBL

A0A2J8MXK0

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:838 → 878

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
XM_009446090.4 → XP_009444365.1 E3 ubiquitin-protein ligase CBL-B isoform X3

UniProtKB/TrEMBL

A0A2I3T5A4, A0A2J8MXK0

Related

ENSPTRP00000084421.1

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:882 → 922

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
XM_009446089.4 → XP_009444364.1 E3 ubiquitin-protein ligase CBL-B isoform X2

UniProtKB/TrEMBL

A0A2I3S4L5, A0A2J8MXK0

Related

ENSPTRP00000071518.1

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:887 → 927

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
XM_003309912.5 → XP_003309960.1 E3 ubiquitin-protein ligase CBL-B isoform X1

See identical proteins and their annotated locations for XP_003309960.1

UniProtKB/TrEMBL

A0A2J8MXK0, A0A2J8MXL5, A0A6D2VUE0, H2QN18

Related

ENSPTRP00000026201.2

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:931 → 971

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
XM_016941588.3 → XP_016797077.1 E3 ubiquitin-protein ligase CBL-B isoform X2

UniProtKB/TrEMBL

A0A2I3S4L5, A0A2J8MXK0

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:887 → 927

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
XM_009446087.4 → XP_009444362.1 E3 ubiquitin-protein ligase CBL-B isoform X1

See identical proteins and their annotated locations for XP_009444362.1

UniProtKB/TrEMBL

A0A2J8MXK0, A0A2J8MXL5, A0A6D2VUE0, H2QN18

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:931 → 971

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
XM_063806102.1 → XP_063662172.1 E3 ubiquitin-protein ligase CBL-B isoform X6
XM_063806099.1 → XP_063662169.1 E3 ubiquitin-protein ligase CBL-B isoform X5
XM_063806105.1 → XP_063662175.1 E3 ubiquitin-protein ligase CBL-B isoform X8
XM_063806104.1 → XP_063662174.1 E3 ubiquitin-protein ligase CBL-B isoform X7
XM_063806103.1 → XP_063662173.1 E3 ubiquitin-protein ligase CBL-B isoform X6
XM_063806100.1 → XP_063662170.1 E3 ubiquitin-protein ligase CBL-B isoform X5
XM_016941591.3 → XP_016797080.1 E3 ubiquitin-protein ligase CBL-B isoform X4

UniProtKB/TrEMBL

A0A2J8MXK0

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:838 → 878

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
XM_016941589.3 → XP_016797078.1 E3 ubiquitin-protein ligase CBL-B isoform X3

UniProtKB/TrEMBL

A0A2I3T5A4, A0A2J8MXK0

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:882 → 922

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
XM_063806098.1 → XP_063662168.1 E3 ubiquitin-protein ligase CBL-B isoform X3

UniProtKB/TrEMBL

A0A2I3T5A4
XM_054680844.2 → XP_054536819.1 E3 ubiquitin-protein ligase CBL-B isoform X2

UniProtKB/TrEMBL

A0A2I3S4L5
XM_009446088.5 → XP_009444363.1 E3 ubiquitin-protein ligase CBL-B isoform X1

See identical proteins and their annotated locations for XP_009444363.1

UniProtKB/TrEMBL

A0A2J8MXK0, A0A2J8MXL5, A0A6D2VUE0, H2QN18

Conserved Domains (5) summary

cd09920
Location:248 → 344

SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain

cd14392
Location:931 → 971

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

pfam02262
Location:44 → 167

Cbl_N; CBL proto-oncogene N-terminal domain 1

pfam02761
Location:171 → 254

Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

cd16709
Location:354 → 419

RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
XM_016941593.4 → XP_016797082.1 E3 ubiquitin-protein ligase CBL-B isoform X10

Conserved Domains (2) summary

cd14392
Location:491 → 531

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

cl17238
Location:5 → 30

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_016941592.4 → XP_016797081.1 E3 ubiquitin-protein ligase CBL-B isoform X9

Conserved Domains (2) summary

cd14392
Location:535 → 575

UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

cl17238
Location:5 → 30

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain