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APC APC regulator of WNT signaling pathway [ Pan troglodytes (chimpanzee) ]

Gene ID: 461999, updated on 3-Apr-2024

Summary

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Official Symbol
APCprovided by VGNC
Official Full Name
APC regulator of WNT signaling pathwayprovided by VGNC
Primary source
VGNC:VGNC:11810
See related
Ensembl:ENSPTRG00000017135
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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See APC in Genome Data Viewer
Location:
chromosome: 5
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 4 NC_072402.2 (110431426..110566327)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 5 NC_072403.1 (110504451..110640267)

Chromosome 4 - NC_072402.2Genomic Context describing neighboring genes Neighboring gene erythrocyte membrane protein band 4.1 like 4A Neighboring gene uncharacterized LOC738385 Neighboring gene uncharacterized LOC104006512 Neighboring gene uncharacterized LOC104006513 Neighboring gene chromobox protein homolog 3-like Neighboring gene U6 spliceosomal RNA Neighboring gene X-box-binding protein 1-like Neighboring gene U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 Neighboring gene uncharacterized LOC104006515 Neighboring gene signal recognition particle 19 Neighboring gene receptor accessory protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables gamma-catenin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell fate specification IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of microtubule depolymerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in pattern specification process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of beta-catenin destruction complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of catenin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic microtubule IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
adenomatous polyposis coli protein
Names
APC, WNT signaling pathway regulator
adenomatosis polyposis coli

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072402.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    110431426..110566327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063810552.1 → XP_063666622.1  adenomatous polyposis coli protein isoform X10

    UniProtKB/TrEMBL
    H2QRB5

  2. XM_063810549.1 → XP_063666619.1  adenomatous polyposis coli protein isoform X7

  3. XM_063810566.1 → XP_063666636.1  adenomatous polyposis coli protein isoform X16

  4. XM_063810568.1 → XP_063666638.1  adenomatous polyposis coli protein isoform X19

  5. XM_009449456.5 → XP_009447731.1  adenomatous polyposis coli protein isoform X5

    Conserved Domains (13) summary
    cd00020
    Location:639 → 759
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:1665 → 1689
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:2063 → 2082
    SAMP; SAMP Motif
    pfam05937
    Location:2699 → 2872
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2252 → 2597
    APC_basic; APC basic domain
    pfam11414
    Location:137 → 217
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:760 → 1047
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1064 → 1163
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1311 → 1396
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1690 → 1746
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1767 → 1867
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1904 → 1975
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    sd00043
    Location:591 → 623
    ARM; armadillo repeat [structural motif]

  6. XM_009449466.5 → XP_009447741.1  adenomatous polyposis coli protein isoform X8

    Conserved Domains (13) summary
    cd00020
    Location:621 → 741
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:1647 → 1671
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:2045 → 2064
    SAMP; SAMP Motif
    pfam05937
    Location:2681 → 2854
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2234 → 2579
    APC_basic; APC basic domain
    pfam11414
    Location:137 → 217
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:742 → 1029
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1046 → 1145
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1293 → 1378
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1672 → 1728
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1749 → 1849
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1886 → 1957
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    sd00043
    Location:475 → 518
    ARM; armadillo repeat [structural motif]

  7. XM_024356693.3 → XP_024212461.1  adenomatous polyposis coli protein isoform X17

    Conserved Domains (14) summary
    smart00185
    Location:558 → 598
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:600 → 640
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:374 → 417
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1546 → 1569
    APC_r; APC repeat
    pfam05924
    Location:1943 → 1962
    SAMP; SAMP Motif
    pfam05937
    Location:2580 → 2753
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2133 → 2478
    APC_basic; APC basic domain
    pfam11414
    Location:137 → 217
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:641 → 927
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:945 → 1044
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1192 → 1277
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1571 → 1624
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1655 → 1748
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1782 → 1856
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

  8. XM_063810557.1 → XP_063666627.1  adenomatous polyposis coli protein isoform X13

  9. XM_063810560.1 → XP_063666630.1  adenomatous polyposis coli protein isoform X14

  10. XM_063810561.1 → XP_063666631.1  adenomatous polyposis coli protein isoform X14

  11. XM_009449459.5 → XP_009447734.1  adenomatous polyposis coli protein isoform X7

    See identical proteins and their annotated locations for XP_009447734.1

    Conserved Domains (16) summary
    smart00185
    Location:667 → 707
    ARM; Armadillo/beta-catenin-like repeats
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
    sd00043
    Location:581 → 613
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1655 → 1678
    APC_r; APC repeat
    pfam05924
    Location:2052 → 2071
    SAMP; SAMP Motif
    pfam05937
    Location:2689 → 2862
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2242 → 2587
    APC_basic; APC basic domain
    pfam11414
    Location:127 → 207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:750 → 1036
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1054 → 1153
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1301 → 1386
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1680 → 1733
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1764 → 1857
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1891 → 1965
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl21727
    Location:551 → 752
    VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
    cl25732
    Location:4 → 272
    SMC_N; RecF/RecN/SMC N terminal domain

  12. XM_063810554.1 → XP_063666624.1  adenomatous polyposis coli protein isoform X10

    UniProtKB/TrEMBL
    H2QRB5

  13. XM_063810567.1 → XP_063666637.1  adenomatous polyposis coli protein isoform X16

  14. XM_063810570.1 → XP_063666640.1  adenomatous polyposis coli protein isoform X19

  15. XM_016953626.4 → XP_016809115.2  adenomatous polyposis coli protein isoform X6

    Conserved Domains (14) summary
    smart00185
    Location:647 → 687
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:689 → 729
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:561 → 593
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1635 → 1658
    APC_r; APC repeat
    pfam05924
    Location:2032 → 2051
    SAMP; SAMP Motif
    pfam05937
    Location:2669 → 2842
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2222 → 2567
    APC_basic; APC basic domain
    pfam11414
    Location:107 → 187
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:730 → 1016
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1034 → 1133
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1281 → 1366
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1660 → 1713
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1744 → 1837
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1871 → 1945
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

  16. XM_024356689.3 → XP_024212457.1  adenomatous polyposis coli protein isoform X9

    Conserved Domains (14) summary
    smart00185
    Location:629 → 669
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:671 → 711
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:445 → 488
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1617 → 1640
    APC_r; APC repeat
    pfam05924
    Location:2014 → 2033
    SAMP; SAMP Motif
    pfam05937
    Location:2651 → 2824
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2204 → 2549
    APC_basic; APC basic domain
    pfam11414
    Location:107 → 187
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:712 → 998
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1016 → 1115
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1263 → 1348
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1642 → 1695
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1726 → 1819
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1853 → 1927
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

  17. XM_024356694.3 → XP_024212462.1  adenomatous polyposis coli protein isoform X18

    Conserved Domains (14) summary
    smart00185
    Location:528 → 568
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:570 → 610
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:344 → 387
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1516 → 1539
    APC_r; APC repeat
    pfam05924
    Location:1913 → 1932
    SAMP; SAMP Motif
    pfam05937
    Location:2550 → 2723
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2103 → 2448
    APC_basic; APC basic domain
    pfam11414
    Location:107 → 187
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:611 → 897
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:915 → 1014
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1162 → 1247
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1541 → 1594
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1625 → 1718
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1752 → 1826
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

  18. XM_016953625.4 → XP_016809114.2  adenomatous polyposis coli protein isoform X3

    Conserved Domains (14) summary
    smart00185
    Location:683 → 723
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:725 → 765
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:597 → 629
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1671 → 1694
    APC_r; APC repeat
    pfam05924
    Location:2068 → 2087
    SAMP; SAMP Motif
    pfam05937
    Location:2705 → 2878
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2258 → 2603
    APC_basic; APC basic domain
    pfam11414
    Location:143 → 223
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:766 → 1052
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1070 → 1169
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1317 → 1402
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1696 → 1749
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1780 → 1873
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1907 → 1981
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

  19. XM_024356687.3 → XP_024212455.1  adenomatous polyposis coli protein isoform X4

    Conserved Domains (14) summary
    smart00185
    Location:665 → 705
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:707 → 747
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:481 → 524
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1653 → 1676
    APC_r; APC repeat
    pfam05924
    Location:2050 → 2069
    SAMP; SAMP Motif
    pfam05937
    Location:2687 → 2860
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2240 → 2585
    APC_basic; APC basic domain
    pfam11414
    Location:143 → 223
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:748 → 1034
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1052 → 1151
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1299 → 1384
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1678 → 1731
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1762 → 1855
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1889 → 1963
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

  20. XM_024356692.3 → XP_024212460.1  adenomatous polyposis coli protein isoform X15

    Conserved Domains (14) summary
    smart00185
    Location:564 → 604
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:606 → 646
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:380 → 423
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1552 → 1575
    APC_r; APC repeat
    pfam05924
    Location:1949 → 1968
    SAMP; SAMP Motif
    pfam05937
    Location:2586 → 2759
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2139 → 2484
    APC_basic; APC basic domain
    pfam11414
    Location:143 → 223
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:647 → 933
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:951 → 1050
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1198 → 1283
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1577 → 1630
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1661 → 1754
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1788 → 1862
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

  21. XM_063810556.1 → XP_063666626.1  adenomatous polyposis coli protein isoform X10

    UniProtKB/TrEMBL
    H2QRB5

  22. XM_063810555.1 → XP_063666625.1  adenomatous polyposis coli protein isoform X10

    UniProtKB/TrEMBL
    H2QRB5

  23. XM_063810551.1 → XP_063666621.1  adenomatous polyposis coli protein isoform X7

  24. XM_063810559.1 → XP_063666629.1  adenomatous polyposis coli protein isoform X13

  25. XM_063810558.1 → XP_063666628.1  adenomatous polyposis coli protein isoform X13

  26. XM_063810565.1 → XP_063666635.1  adenomatous polyposis coli protein isoform X14

  27. XM_054684528.2 → XP_054540503.1  adenomatous polyposis coli protein isoform X16

  28. XM_063810571.1 → XP_063666641.1  adenomatous polyposis coli protein isoform X19

  29. XM_063810550.1 → XP_063666620.1  adenomatous polyposis coli protein isoform X7

  30. XM_063810563.1 → XP_063666633.1  adenomatous polyposis coli protein isoform X14

  31. XM_063810564.1 → XP_063666634.1  adenomatous polyposis coli protein isoform X14

  32. XM_024356686.3 → XP_024212454.1  adenomatous polyposis coli protein isoform X1

    Conserved Domains (14) summary
    smart00185
    Location:682 → 722
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:724 → 764
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:596 → 628
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1670 → 1693
    APC_r; APC repeat
    pfam05924
    Location:2067 → 2086
    SAMP; SAMP Motif
    pfam05937
    Location:2704 → 2877
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2257 → 2602
    APC_basic; APC basic domain
    pfam11414
    Location:142 → 222
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:765 → 1051
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1069 → 1168
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1316 → 1401
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1695 → 1748
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1779 → 1872
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1906 → 1980
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

  33. XM_016953628.4 → XP_016809117.2  adenomatous polyposis coli protein isoform X11

    Conserved Domains (14) summary
    smart00185
    Location:581 → 621
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:623 → 663
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:495 → 527
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1569 → 1592
    APC_r; APC repeat
    pfam05924
    Location:1966 → 1985
    SAMP; SAMP Motif
    pfam05937
    Location:2603 → 2776
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2156 → 2501
    APC_basic; APC basic domain
    pfam11414
    Location:142 → 222
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:664 → 950
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:968 → 1067
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1215 → 1300
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1594 → 1647
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1678 → 1771
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1805 → 1879
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

  34. XM_016953624.4 → XP_016809113.2  adenomatous polyposis coli protein isoform X2

    Conserved Domains (14) summary
    smart00185
    Location:664 → 704
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:706 → 746
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:480 → 523
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1652 → 1675
    APC_r; APC repeat
    pfam05924
    Location:2049 → 2068
    SAMP; SAMP Motif
    pfam05937
    Location:2686 → 2859
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2239 → 2584
    APC_basic; APC basic domain
    pfam11414
    Location:142 → 222
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:747 → 1033
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1051 → 1150
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1298 → 1383
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1677 → 1730
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1761 → 1854
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1888 → 1962
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

  35. XM_024356690.3 → XP_024212458.1  adenomatous polyposis coli protein isoform X12

    Conserved Domains (14) summary
    smart00185
    Location:563 → 603
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:605 → 645
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:379 → 422
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:1551 → 1574
    APC_r; APC repeat
    pfam05924
    Location:1948 → 1967
    SAMP; SAMP Motif
    pfam05937
    Location:2585 → 2758
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2138 → 2483
    APC_basic; APC basic domain
    pfam11414
    Location:142 → 222
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:646 → 932
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:950 → 1049
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1197 → 1282
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1576 → 1629
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1660 → 1753
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1787 → 1861
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
Nucleotide Protein
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