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F8 coagulation factor VIII [ Pan troglodytes (chimpanzee) ]

Gene ID: 473838, updated on 3-Apr-2024

Summary

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Official Symbol
F8provided by VGNC
Official Full Name
coagulation factor VIIIprovided by VGNC
Primary source
VGNC:VGNC:7458
Locus tag
CK820_G0050659
See related
Ensembl:ENSPTRG00000022455
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: X
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) X NC_072421.2 (152232732..152422057, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) X NC_072421.1 (152229831..152418044, complement)

Chromosome X - NC_072421.2Genomic Context describing neighboring genes Neighboring gene non-histone chromosomal protein HMG-14-like Neighboring gene small integral membrane protein 9 Neighboring gene microRNA mir-1184-2 Neighboring gene H2A.B variant histone 1 Neighboring gene coagulation factor VIII associated 1 Neighboring gene FUN14 domain containing 2 Neighboring gene mature T cell proliferation 1 Neighboring gene C-X9-C motif containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
coagulation factor VIII
Names
coagulation factor VIII, procoagulant component

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072421.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    152232732..152422057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016944624.3 → XP_016800113.1  coagulation factor VIII isoform X2

  2. XM_003317789.6 → XP_003317837.1  coagulation factor VIII isoform X1

    UniProtKB/TrEMBL
    A0A2J8J4T5, A0A6D2WSP0, H2R1R6
    Related
    ENSPTRP00000042755.4
    Conserved Domains (7) summary
    cd00057
    Location:2195 → 2344
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd04227
    Location:399 → 575
    CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins
    cd04228
    Location:1714 → 1880
    CuRO_5_FVIII_like; The fifth cupredoxin domain of coagulation factor VIII and similar proteins
    cd11015
    Location:211 → 345
    CuRO_2_FVIII_like; The second cupredoxin domain of coagulation factor VIII and similar proteins
    cd11016
    Location:588 → 730
    CuRO_4_FVIII_like; The fourth cupredoxin domain of coagulation factor VIII and similar proteins
    cd11018
    Location:1892 → 2035
    CuRO_6_FVIII_like; The sixth cupredoxin domain of coagulation factor VIII and similar proteins
    cd14452
    Location:22 → 201
    CuRO_1_FVIII_like; The first cupredoxin domain of coagulation factor VIII and similar proteins

  3. XM_063804695.1 → XP_063660765.1  coagulation factor VIII isoform X6

  4. XM_063804694.1 → XP_063660764.1  coagulation factor VIII isoform X5

  5. XM_016944625.4 → XP_016800114.1  coagulation factor VIII isoform X3

  6. XM_009439870.4 → XP_009438145.1  coagulation factor VIII isoform X4

    Conserved Domains (7) summary
    smart00231
    Location:1804 → 1953
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:1960 → 2109
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd04227
    Location:164 → 340
    CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins
    cd04228
    Location:1479 → 1645
    CuRO_5_FVIII_like; The fifth cupredoxin domain of coagulation factor VIII and similar proteins
    cd11016
    Location:353 → 495
    CuRO_4_FVIII_like; The fourth cupredoxin domain of coagulation factor VIII and similar proteins
    cd11018
    Location:1657 → 1800
    CuRO_6_FVIII_like; The sixth cupredoxin domain of coagulation factor VIII and similar proteins
    cl19115
    Location:1 → 110
    Cupredoxin; Cupredoxin superfamily

  7. XM_016944627.4 → XP_016800116.1  coagulation factor VIII isoform X7

  8. XM_054676351.2 → XP_054532326.1  coagulation factor VIII isoform X8

Nucleotide Protein
Heading Accession and Version

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