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FBXW7 F-box and WD repeat domain containing 7 [ Canis lupus familiaris (dog) ]

Gene ID: 475465, updated on 5-Mar-2024

Summary

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Official Symbol
FBXW7provided by VGNC
Official Full Name
F-box and WD repeat domain containing 7provided by VGNC
Primary source
VGNC:VGNC:40797
See related
Ensembl:ENSCAFG00845007020
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See FBXW7 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 15 NC_051819.1 (50869433..51101086, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 15 NC_006597.4 (50529850..50761421, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 15 NC_049236.1 (50542860..50774097, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 15 NC_049275.1 (50130239..50363954, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 15 NC_049756.1 (50231872..50463188, complement)

Chromosome 15 - NC_051819.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111090094 Neighboring gene uncharacterized LOC119868714 Neighboring gene U6 spliceosomal RNA Neighboring gene short coiled-coil protein Neighboring gene uncharacterized LOC111090096 Neighboring gene uncharacterized LOC119869289

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of novel genetic risk loci in Maltese dogs with necrotizing meningoencephalitis and evidence of a shared genetic risk across toy dog breeds. Schrauwen I, et al. PLoS One, 2014. PMID 25393235, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Haplotype analysis and fine-mapping suggests that ILR7 and FBXW7 could be the underlying associated genes with necrotizing meningoencephalitis.
    Title: Identification of novel genetic risk loci in Maltese dogs with necrotizing meningoencephalitis and evidence of a shared genetic risk across toy dog breeds.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin recycling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
F-box/WD repeat-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051819.1 Reference ROS_Cfam_1.0

    Range
    50869433..51101086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038688632.1 → XP_038544560.1  F-box/WD repeat-containing protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LSD7, A0A8C0MVQ8, A0A8C0S7B0, A0A8I3N0Z3
    Conserved Domains (3) summary
    cd00200
    Location:379 → 655
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:389 → 424
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:286 → 330
    F-box-like

  2. XM_038688633.1 → XP_038544561.1  F-box/WD repeat-containing protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LSD7, A0A8C0MVQ8, A0A8C0S7B0, A0A8I3N0Z3
    Related
    ENSCAFP00845009912.1, ENSCAFT00845012707.1
    Conserved Domains (3) summary
    cd00200
    Location:379 → 655
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:389 → 424
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:286 → 330
    F-box-like

  3. XM_038688635.1 → XP_038544563.1  F-box/WD repeat-containing protein 7 isoform X3

    UniProtKB/TrEMBL
    A0A8C0S7D9, A0A8I3N229
    Related
    ENSCAFP00845009946.1, ENSCAFT00845012754.1
    Conserved Domains (3) summary
    cd00200
    Location:256 → 532
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:266 → 301
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:163 → 207
    F-box-like

  4. XM_038688634.1 → XP_038544562.1  F-box/WD repeat-containing protein 7 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LM89, A0A8C0N3B2, A0A8I3N148
    Related
    ENSCAFP00845009972.1, ENSCAFT00845012788.1
    Conserved Domains (3) summary
    cd00200
    Location:294 → 570
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:304 → 339
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:201 → 245
    F-box-like

  5. XM_038688636.1 → XP_038544564.1  F-box/WD repeat-containing protein 7 isoform X4

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049275.1 Alternate UMICH_Zoey_3.1

    Range
    50130239..50363954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038496633.1 → XP_038352561.1  F-box/WD repeat-containing protein 7 isoform X1

    Conserved Domains (3) summary
    cd00200
    Location:379 → 655
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:389 → 424
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:286 → 330
    F-box-like

  2. XM_038496634.1 → XP_038352562.1  F-box/WD repeat-containing protein 7 isoform X1

    Conserved Domains (3) summary
    cd00200
    Location:379 → 655
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:389 → 424
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:286 → 330
    F-box-like

  3. XM_038496636.1 → XP_038352564.1  F-box/WD repeat-containing protein 7 isoform X3

    Conserved Domains (3) summary
    cd00200
    Location:256 → 532
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:266 → 301
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:163 → 207
    F-box-like

  4. XM_038496635.1 → XP_038352563.1  F-box/WD repeat-containing protein 7 isoform X2

    Conserved Domains (3) summary
    cd00200
    Location:294 → 570
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:304 → 339
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:201 → 245
    F-box-like

  5. XM_038496637.1 → XP_038352565.1  F-box/WD repeat-containing protein 7 isoform X4

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049756.1 Alternate UNSW_CanFamBas_1.0

    Range
    50231872..50463188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038622960.1 → XP_038478888.1  F-box/WD repeat-containing protein 7 isoform X1

    Conserved Domains (3) summary
    cd00200
    Location:379 → 655
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:389 → 424
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:286 → 330
    F-box-like

  2. XM_038622961.1 → XP_038478889.1  F-box/WD repeat-containing protein 7 isoform X1

    Conserved Domains (3) summary
    cd00200
    Location:379 → 655
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:389 → 424
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:286 → 330
    F-box-like

  3. XM_038622963.1 → XP_038478891.1  F-box/WD repeat-containing protein 7 isoform X3

    Conserved Domains (3) summary
    cd00200
    Location:256 → 532
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:266 → 301
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:163 → 207
    F-box-like

  4. XM_038622962.1 → XP_038478890.1  F-box/WD repeat-containing protein 7 isoform X2

    Conserved Domains (3) summary
    cd00200
    Location:294 → 570
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:304 → 339
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:201 → 245
    F-box-like

  5. XM_038622964.1 → XP_038478892.1  F-box/WD repeat-containing protein 7 isoform X4

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049236.1 Alternate UU_Cfam_GSD_1.0

    Range
    50542860..50774097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038559027.1 → XP_038414955.1  F-box/WD repeat-containing protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LSD7, A0A8C0MVQ8, A0A8C0S7B0, A0A8I3N0Z3
    Conserved Domains (3) summary
    cd00200
    Location:379 → 655
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:389 → 424
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:286 → 330
    F-box-like

  2. XM_038559028.1 → XP_038414956.1  F-box/WD repeat-containing protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LSD7, A0A8C0MVQ8, A0A8C0S7B0, A0A8I3N0Z3
    Conserved Domains (3) summary
    cd00200
    Location:379 → 655
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:389 → 424
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:286 → 330
    F-box-like

  3. XM_038559030.1 → XP_038414958.1  F-box/WD repeat-containing protein 7 isoform X3

    UniProtKB/TrEMBL
    A0A8C0S7D9, A0A8I3N229
    Conserved Domains (3) summary
    cd00200
    Location:256 → 532
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:266 → 301
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:163 → 207
    F-box-like

  4. XM_038559029.1 → XP_038414957.1  F-box/WD repeat-containing protein 7 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LM89, A0A8C0N3B2, A0A8I3N148
    Conserved Domains (3) summary
    cd00200
    Location:294 → 570
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:304 → 339
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:201 → 245
    F-box-like

  5. XM_038559031.1 → XP_038414959.1  F-box/WD repeat-containing protein 7 isoform X4

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006597.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    50529850..50761421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038449238.1 → XP_038305166.1  F-box/WD repeat-containing protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LSD7, A0A8C0MVQ8, A0A8C0S7B0, A0A8I3N0Z3
    Conserved Domains (3) summary
    cd00200
    Location:379 → 655
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:389 → 424
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:286 → 330
    F-box-like

  2. XM_038449244.1 → XP_038305172.1  F-box/WD repeat-containing protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LSD7, A0A8C0MVQ8, A0A8C0S7B0, A0A8I3N0Z3
    Conserved Domains (3) summary
    cd00200
    Location:379 → 655
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:389 → 424
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:286 → 330
    F-box-like

  3. XM_532689.7 → XP_532689.2  F-box/WD repeat-containing protein 7 isoform X3

    See identical proteins and their annotated locations for XP_532689.2

    UniProtKB/TrEMBL
    A0A8C0S7D9, A0A8I3N229
    Conserved Domains (3) summary
    cd00200
    Location:256 → 532
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:266 → 301
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:163 → 207
    F-box-like

  4. XM_848531.6 → XP_853624.1  F-box/WD repeat-containing protein 7 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LM89, A0A8C0N3B2, A0A8I3N148
    Conserved Domains (3) summary
    cd00200
    Location:294 → 570
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:304 → 339
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:201 → 245
    F-box-like

  5. XM_022403517.2 → XP_022259225.1  F-box/WD repeat-containing protein 7 isoform X4

Nucleotide Protein
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