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NEUROG1 neurogenin 1 [ Homo sapiens (human) ]

Gene ID: 4762, updated on 4-Jan-2025

Summary

Official Symbol
NEUROG1provided by HGNC
Official Full Name
neurogenin 1provided by HGNC
Primary source
HGNC:HGNC:7764
See related
Ensembl:ENSG00000181965 MIM:601726; AllianceGenome:HGNC:7764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AKA; ngn1; CCDDRD; Math4C; bHLHa6; NEUROD3
Summary
Enables E-box binding activity and protein homodimerization activity. Involved in several processes, including cochlea morphogenesis; cranial nerve development; and hard palate morphogenesis. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See NEUROG1 in Genome Data Viewer
Location:
5q31.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (135534282..135535964, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (136061404..136063086, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (134869972..134871654, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134784907-134785408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134785409-134785908 Neighboring gene uncharacterized LOC124901073 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23175 Neighboring gene dendritic cell associated nuclear protein 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:134820245-134821093 Neighboring gene TIFA inhibitor Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134824474-134825331 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134825332-134826188 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134826189-134827045 Neighboring gene MPRA-validated peak5480 silencer Neighboring gene Sharpr-MPRA regulatory region 242 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134871641-134872156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134877514-134878015 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134878708-134879599 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134879600-134880490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134880491-134881382 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:134900858-134901378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134904009-134904938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134905671-134906171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134920433-134920934 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134938767-134939339 Neighboring gene solute carrier family 25 member 48 Neighboring gene C-X-C motif chemokine ligand 14 Neighboring gene SLC25A48 antisense RNA 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding PubMed 
enables DNA-binding transcription factor activity PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific  
enables DNA-binding transcription factor activity, RNA polymerase II-specific  
enables E-box binding  
enables E-box binding PubMed 
enables E-box binding  
enables chromatin binding  
enables protein binding PubMed 
enables protein homodimerization activity PubMed 
enables sequence-specific double-stranded DNA binding PubMed 
Items 1 - 25 of 31
Process Evidence Code Pubs
involved_in auditory behavior PubMed 
involved_in axon development  
involved_in cell fate commitment  
involved_in cochlea development PubMed 
involved_in cochlea morphogenesis PubMed 
involved_in craniofacial suture morphogenesis PubMed 
involved_in exit from mitosis  
involved_in forebrain development  
involved_in genitalia development PubMed 
involved_in genitalia morphogenesis PubMed 
involved_in hard palate morphogenesis PubMed 
involved_in inner ear development PubMed 
involved_in inner ear morphogenesis PubMed 
involved_in learned vocalization behavior PubMed 
involved_in mastication PubMed 
involved_in negative regulation of relaxation of muscle PubMed 
involved_in negative regulation of saliva secretion PubMed 
involved_in nervous system development PubMed 
involved_in neuromuscular process controlling balance PubMed 
involved_in peristalsis PubMed 
involved_in positive regulation of DNA-binding transcription factor activity  
involved_in positive regulation of exit from mitosis  
involved_in positive regulation of neuron differentiation  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in regulation of muscle organ development PubMed 
involved_in regulation of transcription by RNA polymerase II PubMed 
involved_in sensory organ development  
involved_in thorax and anterior abdomen determination PubMed 
involved_in trigeminal nerve development PubMed 
involved_in vestibulocochlear nerve formation PubMed 
Items 1 - 25 of 31
Component Evidence Code Pubs
located_in chromatin  
is_active_in nucleus  
located_in perikaryon  

General protein information

Preferred Names
neurogenin-1
Names
NGN-1
class A basic helix-loop-helix protein 6
neurogenic basic-helix-loop-helix protein
neurogenic differentiation 3
neurogenic differentiation factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006161.3NP_006152.2  neurogenin-1

    See identical proteins and their annotated locations for NP_006152.2

    Status: VALIDATED

    Source sequence(s)
    AC005738, BC028226
    Consensus CDS
    CCDS4187.1
    UniProtKB/Swiss-Prot
    Q5U0Q9, Q92886, Q96HE1
    UniProtKB/TrEMBL
    B2RAP3, F1T0H3
    Related
    ENSP00000317580.4, ENST00000314744.6
    Conserved Domains (1) summary
    cd00083
    Location:90149
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    135534282..135535964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    136061404..136063086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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