NR3C1 nuclear receptor subfamily 3 group C member 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: NR3C1provided by VGNC
Official Full Name: nuclear receptor subfamily 3 group C member 1provided by VGNC
Primary source: VGNC:VGNC:43952
See related: Ensembl:ENSCAFG00845019024
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: GR
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	2	NC_051806.1 (38573084..38692463, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	2	NC_006584.4 (35173176..35283390, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	2	NC_049223.1 (37270194..37380458, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	2	NC_049262.1 (35654977..35765222, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	2	NC_049743.1 (36468553..36579023, complement)

Chromosome 2 - NC_051806.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Restrained expression of canine glucocorticoid receptor splice variants alpha and P prognosticates fatal disease outcome in SIRS.
Title: Restrained expression of canine glucocorticoid receptor splice variants α and P prognosticates fatal disease outcome in SIRS.
It was concludee that NR3C1 polymorphisms occur in dogs and may cause individual variation in response to corticosteroid therapy.
Title: Polymorphisms in the canine glucocorticoid receptor alpha gene (NR3C1α).
the hepatic glucocorticoid receptor plays an important role in the regulation of basal hepatic glucose production
Title: Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

NR3C1_1004 (e-PCR)
- UniSTS:277539

NR3C1_V270 (e-PCR)
- UniSTS:277539

NR3C1 (e-PCR)
- UniSTS:504891

NR3C1 (e-PCR)
- UniSTS:264124

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables nuclear glucocorticoid receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables steroid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in glucocorticoid mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in glucocorticoid receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: glucocorticoid receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302828.1 → NP_001289757.1 glucocorticoid receptor

See identical proteins and their annotated locations for NP_001289757.1

Status: PROVISIONAL

Source sequence(s)

AB874470

UniProtKB/TrEMBL

A0A0A7KLD0, A0A8C0L599, A0A8P0T192

Conserved Domains (3) summary

cd07076
Location:534 → 780

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:420 → 497

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:27 → 405

GCR; Glucocorticoid receptor

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051806.1 Reference ROS_Cfam_1.0

Range

38573084..38692463 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038657799.1 → XP_038513727.1 glucocorticoid receptor isoform X1

UniProtKB/TrEMBL

A0A8C0QLS2, A0A8I3P8F8, A0A8P0T192

Conserved Domains (3) summary

cd07076
Location:535 → 781

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:420 → 498

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:27 → 405

GCR; Glucocorticoid receptor
XM_038657798.1 → XP_038513726.1 glucocorticoid receptor isoform X1

UniProtKB/TrEMBL

A0A8C0QLS2, A0A8I3P8F8, A0A8P0T192

Conserved Domains (3) summary

cd07076
Location:535 → 781

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:420 → 498

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:27 → 405

GCR; Glucocorticoid receptor
XM_038657797.1 → XP_038513725.1 glucocorticoid receptor isoform X1

UniProtKB/TrEMBL

A0A8C0QLS2, A0A8I3P8F8, A0A8P0T192

Related

ENSCAFP00845026354.1, ENSCAFT00845033662.1

Conserved Domains (3) summary

cd07076
Location:535 → 781

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:420 → 498

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:27 → 405

GCR; Glucocorticoid receptor
XM_038657800.1 → XP_038513728.1 glucocorticoid receptor isoform X1

UniProtKB/TrEMBL

A0A8C0QLS2, A0A8I3P8F8, A0A8P0T192

Conserved Domains (3) summary

cd07076
Location:535 → 781

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:420 → 498

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:27 → 405

GCR; Glucocorticoid receptor
XM_038657802.1 → XP_038513730.1 glucocorticoid receptor isoform X2

UniProtKB/TrEMBL

A0A0A7KLD0, A0A8C0L599, A0A8P0T192

Conserved Domains (3) summary

cd07076
Location:534 → 780

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:420 → 497

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:27 → 405

GCR; Glucocorticoid receptor
XM_038657801.1 → XP_038513729.1 glucocorticoid receptor isoform X2

UniProtKB/TrEMBL

A0A0A7KLD0, A0A8C0L599, A0A8P0T192

Conserved Domains (3) summary

cd07076
Location:534 → 780

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:420 → 497

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:27 → 405

GCR; Glucocorticoid receptor