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LCK LCK proto-oncogene, Src family tyrosine kinase [ Canis lupus familiaris (dog) ]

Gene ID: 478151, updated on 11-Apr-2024

Summary

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Official Symbol
LCKprovided by VGNC
Official Full Name
LCK proto-oncogene, Src family tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:42607
See related
Ensembl:ENSCAFG00845004976
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
13
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (69507326..69531453, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (65521599..65545402, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (68338870..68362999, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (66344251..66368026, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (67339915..67363766, complement)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene MARCKS like 1 Neighboring gene histone deacetylase 1 Neighboring gene family with sequence similarity 167 member B Neighboring gene myotubularin-related protein 9-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in T cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase Lck
Names
lymphocyte-specific protein tyrosine kinase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    69507326..69531453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038659541.1 → XP_038515469.1  tyrosine-protein kinase Lck

    UniProtKB/TrEMBL
    A0A8C0LIS5, A0A8C0TE05, A0A8I3NAC6
    Related
    ENSCAFP00845007011.1, ENSCAFT00845008902.1
    Conserved Domains (3) summary
    cd10362
    Location:123 → 223
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:65 → 118
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:237 → 500
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

  2. XM_038659542.1 → XP_038515470.1  tyrosine-protein kinase Lck

    UniProtKB/TrEMBL
    A0A8C0LIS5, A0A8C0TE05, A0A8I3NAC6
    Conserved Domains (3) summary
    cd10362
    Location:123 → 223
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:65 → 118
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:237 → 500
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    66344251..66368026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038470395.1 → XP_038326323.1  tyrosine-protein kinase Lck

    Conserved Domains (3) summary
    cd10362
    Location:123 → 223
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:65 → 118
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:237 → 500
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

  2. XM_038470396.1 → XP_038326324.1  tyrosine-protein kinase Lck

    Conserved Domains (3) summary
    cd10362
    Location:123 → 223
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:65 → 118
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:237 → 500
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    67339915..67363766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038595457.1 → XP_038451385.1  tyrosine-protein kinase Lck

    Conserved Domains (3) summary
    cd10362
    Location:123 → 223
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:65 → 118
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:237 → 500
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

  2. XM_038595458.1 → XP_038451386.1  tyrosine-protein kinase Lck

    Conserved Domains (3) summary
    cd10362
    Location:123 → 223
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:65 → 118
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:237 → 500
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    68338870..68362999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038531235.1 → XP_038387163.1  tyrosine-protein kinase Lck

    UniProtKB/TrEMBL
    A0A8C0LIS5, A0A8C0TE05, A0A8I3NAC6
    Conserved Domains (3) summary
    cd10362
    Location:123 → 223
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:65 → 118
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:237 → 500
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

  2. XM_038531236.1 → XP_038387164.1  tyrosine-protein kinase Lck

    UniProtKB/TrEMBL
    A0A8C0LIS5, A0A8C0TE05, A0A8I3NAC6
    Conserved Domains (3) summary
    cd10362
    Location:123 → 223
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:65 → 118
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:237 → 500
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    65521599..65545402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005617639.3 → XP_005617696.1  tyrosine-protein kinase Lck

    UniProtKB/TrEMBL
    A0A8C0LIS5, A0A8C0TE05, A0A8I3NAC6
    Conserved Domains (3) summary
    cd10362
    Location:123 → 223
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:65 → 118
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:237 → 500
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

  2. XM_022412060.2 → XP_022267768.1  tyrosine-protein kinase Lck

    UniProtKB/TrEMBL
    A0A8C0LIS5, A0A8C0TE05, A0A8I3NAC6
    Conserved Domains (3) summary
    cd10362
    Location:123 → 223
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:65 → 118
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:237 → 500
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
Nucleotide Protein
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