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NCK2 NCK adaptor protein 2 [ Canis lupus familiaris (dog) ]

Gene ID: 481319, updated on 5-Mar-2024

Summary

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Official Symbol
NCK2provided by VGNC
Official Full Name
NCK adaptor protein 2provided by VGNC
Primary source
VGNC:VGNC:43652
See related
Ensembl:ENSCAFG00845009565
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
9
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (38434612..38590460, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (37509022..37661002, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (38636761..38787028, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (38166351..38316130, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (38443073..38594964, complement)

Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097687 Neighboring gene uncharacterized LOC111097688 Neighboring gene uncharacterized LOC106559419 Neighboring gene uncharacterized LOC111097690

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of PERK-mediated unfolded protein response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of translation in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cytoplasmic protein NCK2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051814.1 Reference ROS_Cfam_1.0

    Range
    38434612..38590460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038680167.1 → XP_038536095.1  cytoplasmic protein NCK2

    UniProtKB/TrEMBL
    A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  2. XM_038680166.1 → XP_038536094.1  cytoplasmic protein NCK2

    UniProtKB/TrEMBL
    A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  3. XM_038680165.1 → XP_038536093.1  cytoplasmic protein NCK2

    UniProtKB/TrEMBL
    A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  4. XM_038680168.1 → XP_038536096.1  cytoplasmic protein NCK2

    UniProtKB/TrEMBL
    A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  5. XM_038680164.1 → XP_038536092.1  cytoplasmic protein NCK2

    UniProtKB/TrEMBL
    A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
    Related
    ENSCAFP00845013099.1, ENSCAFT00845016842.1
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049270.1 Alternate UMICH_Zoey_3.1

    Range
    38166351..38316130 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038488915.1 → XP_038344843.1  cytoplasmic protein NCK2

    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  2. XM_038488914.1 → XP_038344842.1  cytoplasmic protein NCK2

    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  3. XM_038488913.1 → XP_038344841.1  cytoplasmic protein NCK2

    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  4. XM_038488916.1 → XP_038344844.1  cytoplasmic protein NCK2

    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  5. XM_038488912.1 → XP_038344840.1  cytoplasmic protein NCK2

    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

    Range
    38443073..38594964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038614795.1 → XP_038470723.1  cytoplasmic protein NCK2

  2. XM_038614794.1 → XP_038470722.1  cytoplasmic protein NCK2

  3. XM_038614793.1 → XP_038470721.1  cytoplasmic protein NCK2

  4. XM_038614796.1 → XP_038470724.1  cytoplasmic protein NCK2

  5. XM_038614792.1 → XP_038470720.1  cytoplasmic protein NCK2

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

    Range
    38636761..38787028 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038550884.1 → XP_038406812.1  cytoplasmic protein NCK2

    UniProtKB/TrEMBL
    A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  2. XM_038550883.1 → XP_038406811.1  cytoplasmic protein NCK2

    UniProtKB/TrEMBL
    A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  3. XM_038550882.1 → XP_038406810.1  cytoplasmic protein NCK2

    UniProtKB/TrEMBL
    A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  4. XM_038550885.1 → XP_038406813.1  cytoplasmic protein NCK2

    UniProtKB/TrEMBL
    A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  5. XM_038550881.1 → XP_038406809.1  cytoplasmic protein NCK2

    UniProtKB/TrEMBL
    A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    37509022..37661002 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038643581.1 → XP_038499509.1  cytoplasmic protein NCK2

    UniProtKB/TrEMBL
    A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  2. XM_005625985.4 → XP_005626042.1  cytoplasmic protein NCK2

    See identical proteins and their annotated locations for XP_005626042.1

    UniProtKB/TrEMBL
    A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  3. XM_038643566.1 → XP_038499494.1  cytoplasmic protein NCK2

    UniProtKB/TrEMBL
    A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  4. XM_005625986.4 → XP_005626043.1  cytoplasmic protein NCK2

    See identical proteins and their annotated locations for XP_005626043.1

    UniProtKB/TrEMBL
    A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  5. XM_005625984.4 → XP_005626041.1  cytoplasmic protein NCK2

    See identical proteins and their annotated locations for XP_005626041.1

    UniProtKB/TrEMBL
    A0A8C0KBU8, A0A8C0P465, A0A8I3N1K5
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein
Nucleotide Protein
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