NMB neuromedin B [Homo sapiens (human)] - Gene

Summary

Official Symbol: NMBprovided by HGNC
Official Full Name: neuromedin Bprovided by HGNC
Primary source: HGNC:HGNC:7842
See related: Ensembl:ENSG00000197696 MIM:162340; AllianceGenome:HGNC:7842
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Expression: Biased expression in fat (RPKM 21.3), brain (RPKM 11.2) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q25.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (84655132..84658199, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (82407545..82410612, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (85198363..85201430, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPNMB is exposed on the surface of dormant breast cancer cells and its activity contributes to the acquisition of stem cell-like properties
Title: Glycoprotein nmb Is Exposed on the Surface of Dormant Breast Cancer Cells and Induces Stem Cell-like Properties.
Genetic clues to the mechanism by which MC4R, FTO, and NMB influences changes in BMI and obesity.
Title: Effects of MC4R, FTO, and NMB gene variants to obesity, physical activity, and eating behavior phenotypes.
Rs2292462 was associated with left ventricular hypertrophy in type 2 diabetic patients.
Title: Genetic variants predicting left ventricular hypertrophy in a diabetic population: a Go-DARTS study including meta-analysis.
There was no association between eating behaviour traits, or anthropometric variables, and NMB p.P73T polymorphism.
Title: Effects of neuromedin-β on caloric compensation, eating behaviours and habitual food intake.
TT genotype of the NMB rs3809508 polymorphism was associated with a higher risk of obesity and moreover, the effects of this polymorphism on anthropometric values were influenced by the maternal educational level.
Title: Influence of maternal educational level on the association between the rs3809508 neuromedin B gene polymorphism and the risk of obesity in the HELENA study.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Influence of maternal educational level on the association between the rs3809508 neuromedin B gene polymorphism and the risk of obesity in the HELENA study.
No significant differences in the genotype distribution were demonstrated between normal weight and overweight/obese subjects
Title: Neuromedin beta: P73T polymorphism in overweight and obese subjects.
Observational study of gene-disease association. (HuGE Navigator)
Title: Neuromedin beta: P73T polymorphism in overweight and obese subjects.
Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)
Title: Significant association between a silent polymorphism in the neuromedin B gene and body weight in German children and adolescents.
REsults describe the expression of neuromedin B in adipose tissue and its regulation by changes in energy balance.
Title: Expression of neuromedin B in adipose tissue and its regulation by changes in energy balance.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2S2557 (e-PCR)
- UniSTS:52659

D15S940 (e-PCR)
- UniSTS:59845

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables hormone activity	TAS Traceable Author Statement more info	PubMed
enables neuromedin B receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Leydig cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in antiviral innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in arachidonic acid secretion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hormone secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of interferon-alpha production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of osteoclast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of respiratory gaseous exchange	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of testosterone secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in sensory perception of itch	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in sneeze reflex	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: neuromedin-B

Names: Neuromedin-B-32; neuromedin-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021077.4 → NP_066563.2 neuromedin-B isoform 1 preproprotein

See identical proteins and their annotated locations for NP_066563.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).

Source sequence(s)

BC007431, BC008603, BI858080

Consensus CDS

CCDS10332.1

UniProtKB/Swiss-Prot

P08949, Q96A06, Q96HH5

Related

ENSP00000353664.3, ENST00000360476.8

Conserved Domains (1) summary

pfam02044
Location:47 → 60

Bombesin; Bombesin-like peptide
NM_205858.2 → NP_995580.1 neuromedin-B isoform 2 preproprotein

See identical proteins and their annotated locations for NP_995580.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a longer and distinct C-terminus, compared to isoform 1.

Source sequence(s)

BC007407, BI858080

Consensus CDS

CCDS42076.1

UniProtKB/Swiss-Prot

P08949

Related

ENSP00000378089.3, ENST00000394588.3

Conserved Domains (1) summary

pfam02044
Location:47 → 60

Bombesin; Bombesin-like peptide