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SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 [ Canis lupus familiaris (dog) ]

Gene ID: 483042, updated on 5-Mar-2024

Summary

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Official Symbol
SOS1provided by VGNC
Official Full Name
SOS Ras/Rac guanine nucleotide exchange factor 1provided by VGNC
Primary source
VGNC:VGNC:46665
See related
Ensembl:ENSCAFG00845022915
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 17 NC_051821.1 (31664627..31805012, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 17 NC_006599.4 (30825007..30830255, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 17 NC_049238.1 (31169723..31309388, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 17 NC_049277.1 (30886361..31025725, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 17 NC_049758.1 (30956021..31095889, complement)

Chromosome 17 - NC_051821.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119869689 Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene uncharacterized LOC111090581 Neighboring gene U6 spliceosomal RNA Neighboring gene cyclin dependent kinase like 4 Neighboring gene uncharacterized LOC106559883 Neighboring gene mRNA cap guanine-N7 methyltransferase-like pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
son of sevenless homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051821.1 Reference ROS_Cfam_1.0

    Range
    31664627..31805012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038691307.1 → XP_038547235.1  son of sevenless homolog 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LAI7, A0A8C0TVC9, A0A8C0Z6U2, A0A8I3PD55
    Related
    ENSCAFP00845031910.1, ENSCAFT00845040761.1
    Conserved Domains (6) summary
    PTZ00449
    Location:1018 → 1295
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00229
    Location:597 → 741
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00325
    Location:204 → 389
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00155
    Location:776 → 1015
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd01261
    Location:439 → 545
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:63 → 169
    Histone; Core histone H2A/H2B/H3/H4

  2. XM_038691306.1 → XP_038547234.1  son of sevenless homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LF60, A0A8C0TUU3, A0A8C0Z6U2, A0A8I3S3D9
    Related
    ENSCAFP00845031780.1, ENSCAFT00845040600.1
    Conserved Domains (6) summary
    PTZ00449
    Location:1018 → 1310
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00229
    Location:597 → 741
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00325
    Location:204 → 389
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00155
    Location:776 → 1015
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd01261
    Location:439 → 545
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:63 → 169
    Histone; Core histone H2A/H2B/H3/H4

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049277.1 Alternate UMICH_Zoey_3.1

    Range
    30886361..31025725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038498768.1 → XP_038354696.1  son of sevenless homolog 1 isoform X2

    Conserved Domains (6) summary
    PTZ00449
    Location:1018 → 1295
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00229
    Location:597 → 741
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00325
    Location:204 → 389
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00155
    Location:776 → 1015
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd01261
    Location:439 → 545
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:63 → 169
    Histone; Core histone H2A/H2B/H3/H4

  2. XM_038498767.1 → XP_038354695.1  son of sevenless homolog 1 isoform X1

    Conserved Domains (6) summary
    PTZ00449
    Location:1018 → 1310
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00229
    Location:597 → 741
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00325
    Location:204 → 389
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00155
    Location:776 → 1015
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd01261
    Location:439 → 545
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:63 → 169
    Histone; Core histone H2A/H2B/H3/H4

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049758.1 Alternate UNSW_CanFamBas_1.0

    Range
    30956021..31095889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038625376.1 → XP_038481304.1  son of sevenless homolog 1 isoform X2

    Conserved Domains (6) summary
    PTZ00449
    Location:1018 → 1295
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00229
    Location:597 → 741
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00325
    Location:204 → 389
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00155
    Location:776 → 1015
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd01261
    Location:439 → 545
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:63 → 169
    Histone; Core histone H2A/H2B/H3/H4

  2. XM_038625375.1 → XP_038481303.1  son of sevenless homolog 1 isoform X1

    Conserved Domains (6) summary
    PTZ00449
    Location:1018 → 1310
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00229
    Location:597 → 741
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00325
    Location:204 → 389
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00155
    Location:776 → 1015
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd01261
    Location:439 → 545
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:63 → 169
    Histone; Core histone H2A/H2B/H3/H4

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049238.1 Alternate UU_Cfam_GSD_1.0

    Range
    31169723..31309388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038561328.1 → XP_038417256.1  son of sevenless homolog 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LAI7, A0A8C0TVC9, A0A8C0Z6U2, A0A8I3PD55
    Conserved Domains (6) summary
    PTZ00449
    Location:1018 → 1295
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00229
    Location:597 → 741
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00325
    Location:204 → 389
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00155
    Location:776 → 1015
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd01261
    Location:439 → 545
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:63 → 169
    Histone; Core histone H2A/H2B/H3/H4

  2. XM_038561327.1 → XP_038417255.1  son of sevenless homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LF60, A0A8C0TUU3, A0A8C0Z6U2, A0A8I3S3D9
    Conserved Domains (6) summary
    PTZ00449
    Location:1018 → 1310
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00229
    Location:597 → 741
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00325
    Location:204 → 389
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00155
    Location:776 → 1015
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd01261
    Location:439 → 545
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:63 → 169
    Histone; Core histone H2A/H2B/H3/H4

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006599.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    30825007..30830255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_005310969.1 RNA Sequence

Nucleotide Protein
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