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JAG1 jagged canonical Notch ligand 1 [ Canis lupus familiaris (dog) ]

Gene ID: 485769, updated on 5-Mar-2024

Summary

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Official Symbol
JAG1provided by VGNC
Official Full Name
jagged canonical Notch ligand 1provided by VGNC
Primary source
VGNC:VGNC:42172
See related
Ensembl:ENSCAFG00845024085
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See JAG1 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
26
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 24 NC_051828.1 (12068191..12103901)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 24 NC_006606.4 (11476448..11510591)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 24 NC_049245.1 (12117643..12153536)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 24 NC_049284.1 (11675811..11709929)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 24 NC_049765.1 (11775152..11810791)

Chromosome 24 - NC_051828.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106557727 Neighboring gene SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-like Neighboring gene SLX4 interacting protein Neighboring gene Ewing sarcoma breakpoint region 1 pseudogene Neighboring gene MKKS centrosomal shuttling protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Jagged 1 Rescues the Duchenne Muscular Dystrophy Phenotype. Vieira NM, et al. Cell, 2015 Nov 19. PMID 26582133, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Notch binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment or maintenance of epithelial cell apical/basal polarity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein jagged-1
Names
jagged 1 (Alagille syndrome)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051828.1 Reference ROS_Cfam_1.0

    Range
    12068191..12103901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038433131.1 → XP_038289059.1  protein jagged-1

    UniProtKB/TrEMBL
    A0A8C0NND2, A0A8C0NXU1, A0A8I3Q037
    Related
    ENSCAFP00845033364.1, ENSCAFT00845042558.1
    Conserved Domains (5) summary
    smart00215
    Location:863 → 930
    VWC_out; von Willebrand factor (vWF) type C domain
    cd00054
    Location:629 → 665
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:748 → 777
    EGF; EGF-like domain
    pfam01414
    Location:167 → 229
    DSL; Delta serrate ligand
    pfam07657
    Location:32 → 107
    MNNL; N-terminus of Notch ligand

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049284.1 Alternate UMICH_Zoey_3.1

    Range
    11675811..11709929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038508330.1 → XP_038364258.1  protein jagged-1

    Conserved Domains (5) summary
    smart00215
    Location:863 → 930
    VWC_out; von Willebrand factor (vWF) type C domain
    cd00054
    Location:629 → 665
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:748 → 777
    EGF; EGF-like domain
    pfam01414
    Location:167 → 229
    DSL; Delta serrate ligand
    pfam07657
    Location:32 → 107
    MNNL; N-terminus of Notch ligand

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049765.1 Alternate UNSW_CanFamBas_1.0

    Range
    11775152..11810791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038635855.1 → XP_038491783.1  protein jagged-1

    Conserved Domains (5) summary
    smart00215
    Location:863 → 930
    VWC_out; von Willebrand factor (vWF) type C domain
    cd00054
    Location:629 → 665
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:748 → 777
    EGF; EGF-like domain
    pfam01414
    Location:167 → 229
    DSL; Delta serrate ligand
    pfam07657
    Location:32 → 107
    MNNL; N-terminus of Notch ligand

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049245.1 Alternate UU_Cfam_GSD_1.0

    Range
    12117643..12153536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038571605.1 → XP_038427533.1  protein jagged-1

    UniProtKB/TrEMBL
    A0A8C0NND2, A0A8C0NXU1, A0A8I3Q037
    Conserved Domains (5) summary
    smart00215
    Location:863 → 930
    VWC_out; von Willebrand factor (vWF) type C domain
    cd00054
    Location:629 → 665
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:748 → 777
    EGF; EGF-like domain
    pfam01414
    Location:167 → 229
    DSL; Delta serrate ligand
    pfam07657
    Location:32 → 107
    MNNL; N-terminus of Notch ligand

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006606.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    11476448..11510591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005634783.4 → XP_005634840.1  protein jagged-1

    UniProtKB/TrEMBL
    A0A8C0NND2, A0A8C0NXU1, A0A8I3Q037
    Conserved Domains (5) summary
    smart00215
    Location:863 → 930
    VWC_out; von Willebrand factor (vWF) type C domain
    cd00054
    Location:629 → 665
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:748 → 777
    EGF; EGF-like domain
    pfam01414
    Location:167 → 229
    DSL; Delta serrate ligand
    pfam07657
    Location:32 → 107
    MNNL; N-terminus of Notch ligand
Nucleotide Protein
Heading Accession and Version

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