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CHAT choline O-acetyltransferase [ Canis lupus familiaris (dog) ]

Gene ID: 486775, updated on 5-Mar-2024

Summary

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Official Symbol
CHATprovided by VGNC
Official Full Name
choline O-acetyltransferaseprovided by VGNC
Primary source
VGNC:VGNC:39192
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See CHAT in Genome Data Viewer
Location:
chromosome: 28
Exon count:
18
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 28 NC_051832.1 (1656110..1708901)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 28 NC_006610.4 (1713916..1766663)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 28 NC_049249.1 (1622347..1675117)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 28 NC_049288.1 (1453354..1506122)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 28 NC_049769.1 (1490456..1543271)

Chromosome 28 - NC_051832.1Genomic Context describing neighboring genes Neighboring gene ERCC excision repair 6, chromatin remodeling factor Neighboring gene thymosin beta-4-like Neighboring gene solute carrier family 18 member A3 Neighboring gene mitochondrial import inner membrane translocase subunit TIM14-like Neighboring gene chromosome 28 C10orf53 homolog Neighboring gene ATP synthase F(0) complex subunit C2, mitochondrial-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a mutation in the CHAT gene of Old Danish Pointing Dogs affected with congenital myasthenic syndrome. Proschowsky HF, et al. J Hered, 2007. PMID 17586598
  2. Microtubule associated protein 2 and choline acetyltransferase immunoreactivity in the lumbar spinal cord of young adult and aged dogs. Hwang IK, et al. Res Vet Sci, 2011 Dec. PMID 21435670

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Changes in choline O-acetyltransferase choline acetyltransferase and microtubule-associated protein 2 associated with age are reported.
    Title: Microtubule associated protein 2 and choline acetyltransferase immunoreactivity in the lumbar spinal cord of young adult and aged dogs.
  2. Mutation causes a valine to methionine substitution and segregates in agreement with the inheritance of congenital myasthenic syndrome.
    Title: Identification of a mutation in the CHAT gene of Old Danish Pointing Dogs affected with congenital myasthenic syndrome.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables choline O-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetylcholine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuromuscular synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
choline O-acetyltransferase; LOW QUALITY PROTEIN: choline O-acetyltransferase
Names
choline acetyltransferase
XP_038295632.1
XP_038316593.1
XP_038371611.1
XP_038435152.1
XP_038499391.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051832.1 Reference ROS_Cfam_1.0

    Range
    1656110..1708901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038439704.1 → XP_038295632.1  LOW QUALITY PROTEIN: choline O-acetyltransferase

    Conserved Domains (1) summary
    pfam00755
    Location:212 → 791
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049288.1 Alternate UMICH_Zoey_3.1

    Range
    1453354..1506122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038515683.1 → XP_038371611.1  LOW QUALITY PROTEIN: choline O-acetyltransferase

    Conserved Domains (1) summary
    pfam00755
    Location:212 → 791
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049769.1 Alternate UNSW_CanFamBas_1.0

    Range
    1490456..1543271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038643463.1 → XP_038499391.1  LOW QUALITY PROTEIN: choline O-acetyltransferase

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049249.1 Alternate UU_Cfam_GSD_1.0

    Range
    1622347..1675117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038579224.1 → XP_038435152.1  LOW QUALITY PROTEIN: choline O-acetyltransferase

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006610.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    1713916..1766663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038460665.1 → XP_038316593.1  LOW QUALITY PROTEIN: choline O-acetyltransferase

    Conserved Domains (1) summary
    pfam00755
    Location:212 → 791
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
Nucleotide Protein
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