DFFA DNA fragmentation factor subunit alpha [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: DFFAprovided by VGNC
Official Full Name: DNA fragmentation factor subunit alphaprovided by VGNC
Primary source: VGNC:VGNC:111433
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	2	NC_051806.1 (86099825..86107488)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	2	NC_006584.4 (81966306..81973968)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	2	NC_049223.1 (84912608..84920270)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	2	NC_049262.1 (82847197..82854858)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	2	NC_049743.1 (83849698..83857360)

Chromosome 2 - NC_051806.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables deoxyribonuclease inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic DNA fragmentation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: DNA fragmentation factor subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051806.1 Reference ROS_Cfam_1.0

Range

86099825..86107488

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038660380.1 → XP_038516308.1 DNA fragmentation factor subunit alpha

UniProtKB/TrEMBL

A0A8C0QM79, A0A8C0QMB2, A0A8I3MHQ9

Conserved Domains (2) summary

pfam09033
Location:96 → 260

DFF-C; DNA Fragmentation factor 45kDa, C terminal domain

cl02541
Location:14 → 92

CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049262.1 Alternate UMICH_Zoey_3.1

Range

82847197..82854858

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038471129.1 → XP_038327057.1 DNA fragmentation factor subunit alpha

Conserved Domains (2) summary

pfam09033
Location:96 → 260

DFF-C; DNA Fragmentation factor 45kDa, C terminal domain

cl02541
Location:14 → 92

CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049743.1 Alternate UNSW_CanFamBas_1.0

Range

83849698..83857360

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038596305.1 → XP_038452233.1 DNA fragmentation factor subunit alpha

Conserved Domains (2) summary

pfam09033
Location:96 → 260

DFF-C; DNA Fragmentation factor 45kDa, C terminal domain

cl02541
Location:14 → 92

CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049223.1 Alternate UU_Cfam_GSD_1.0

Range

84912608..84920270

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038532043.1 → XP_038387971.1 DNA fragmentation factor subunit alpha

UniProtKB/TrEMBL

A0A8C0QM79, A0A8C0QMB2, A0A8I3MHQ9

Conserved Domains (2) summary

pfam09033
Location:96 → 260

DFF-C; DNA Fragmentation factor 45kDa, C terminal domain

cl02541
Location:14 → 92

CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

81966306..81973968

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_544574.6 → XP_544574.2 DNA fragmentation factor subunit alpha

UniProtKB/TrEMBL

A0A8C0QM79, A0A8C0QMB2, A0A8I3MHQ9

Conserved Domains (2) summary

pfam09033
Location:96 → 260

DFF-C; DNA Fragmentation factor 45kDa, C terminal domain

cl02541
Location:14 → 92

CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...