il4r.1 interleukin 4 receptor, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: il4r.1provided by ZNC
Official Full Name: interleukin 4 receptor, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050227-5
See related: Ensembl:ENSDARG00000102583 AllianceGenome:ZFIN:ZDB-GENE-050227-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: il4r; il-4ra; zgc:113063
Summary: Enables interleukin-4 binding activity. Acts upstream of or within neurogenesis and regeneration. Located in plasma membrane. Is expressed in several structures, including digestive system; gill; immune system; integument; and ovary. Human ortholog(s) of this gene implicated in several diseases, including acne; allergic conjunctivitis; autoimmune disease (multiple); human immunodeficiency virus infectious disease; and renal tuberculosis. Orthologous to human IL4R (interleukin 4 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (44048976..44060032, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (43347636..43359115, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish IL-4Ralpha shares overall conserved structural features of the IL-4Ralpha family; IL-4Ralpha is distributed on B cells.
Title: Essential role of IL-4 and IL-4Rα interaction in adaptive immunity of zebrafish: insight into the origin of Th2-like regulatory mechanism in ancient vertebrates.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-4 binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within production of molecular mediator involved in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interleukin 4 receptor, tandem duplicate 1

Names: DrIL-4Ralpha; IL-4RA-like protein 1; il-4alpha; interleukin 4 receptor alpha; soluble IL-4 receptor alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013282.2 → NP_001013300.1 interleukin 4 receptor, tandem duplicate 1 precursor

See identical proteins and their annotated locations for NP_001013300.1

Status: PROVISIONAL

Source sequence(s)

BC090264

UniProtKB/TrEMBL

Q5EAS6

Related

ENSDARP00000135831.1, ENSDART00000165628.2

Conserved Domains (1) summary

pfam09238
Location:27 → 112

IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

44048976..44060032 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005164209.4 → XP_005164266.1 interleukin 4 receptor, tandem duplicate 1 isoform X1

UniProtKB/TrEMBL

A0A8M2BBP4

Related

ENSDARP00000136257.1, ENSDART00000158485.2

Conserved Domains (1) summary

pfam09238
Location:79 → 164

IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal