HSPA14 heat shock protein family A (Hsp70) member 14 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HSPA14provided by HGNC
Official Full Name: heat shock protein family A (Hsp70) member 14provided by HGNC
Primary source: HGNC:HGNC:29526
See related: Ensembl:ENSG00000187522 MIM:610369; AllianceGenome:HGNC:29526
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HSP70-4; HSP70L1; MSANTD7
Summary: Predicted to enable several functions, including ATP binding activity; misfolded protein binding activity; and unfolded protein binding activity. Predicted to be involved in several processes, including cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Located in cytosol. Colocalizes with ribosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis (RPKM 8.1), bone marrow (RPKM 6.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10p13

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (14838306..14871741)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (14852271..14885706)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (14880305..14913740)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of HSPA14 in patients with acute HIV-1 infection and its effect on HIV-1 replication.
Title: Expression of HSPA14 in patients with acute HIV-1 infection and its effect on HIV-1 replication.
Intracellular HSP70L1 inhibits human dendritic cell maturation by promoting suppressive H3K27me3 and H2AK119Ub1 histone modifications.
Title: Intracellular HSP70L1 inhibits human dendritic cell maturation by promoting suppressive H3K27me3 and H2AK119Ub1 histone modifications.
HSP70L1 expression is induced by TERT.TERT promotes formation of a telomere protective complex containing Hsp70L1.
Title: Telomerase promotes formation of a telomere protective complex in cancer cells.
TLR4 is a key receptor mediating the interaction of Hsp70L1 with DCs and subsequently enhancing the induction of Th1 immune response by Hsp70L1/antigen fusion protein
Title: Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response.
a novel pathway (NBS1-HSF4b-HSPA4/HSPA14 axis) to induce migration, invasion, and transformation, suggesting the activation of multiple signaling events induced by NBS1 overexpression
Title: Induction of HSPA4 and HSPA14 by NBS1 overexpression contributes to NBS1-induced in vitro metastatic and transformation activity.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.
results demonstrate that Hsp70L1 has enhanced Th1 polarizing and adjuvant properties, which appear to be mediated via activation of dendritic cells
Title: Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of heat shock 70kDa protein 14 (HSPA14) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity	PubMed
	env	The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein	PubMed
Pr55(Gag)	gag	Hsp70 co-sediments with HIV-1 capsid protein in sucrose density gradients, providing evidence that it is specifically incorporated into HIV-1 virions through an interaction with HIV-1 Gag proteins	PubMed
	gag	Hsp70 is incorporated into HIV-1 virions through an interaction with HIV-1 Gag	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-34289 (e-PCR)
- UniSTS:4695

WI-12176 (e-PCR)
- UniSTS:11107

RH45792 (e-PCR)
- UniSTS:30831

A006X45 (e-PCR)
- UniSTS:60786

G35510 (e-PCR)
- UniSTS:44150

A005E19 (e-PCR)
- UniSTS:9942

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in 'de novo' cotranslational protein folding	TAS Traceable Author Statement more info	PubMed
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
colocalizes_with ribosome	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with ribosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heat shock 70 kDa protein 14

Names: HSP70-like protein 1; heat shock protein HSP60; heat shock protein hsp70-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016299.4 → NP_057383.2 heat shock 70 kDa protein 14

See identical proteins and their annotated locations for NP_057383.2

Status: VALIDATED

Source sequence(s)

AF112210, BC119690, BP201211

Consensus CDS

CCDS7103.1

UniProtKB/Swiss-Prot

A8K8F8, B0YIY9, Q0VDF9, Q9P0X2, Q9UI07

Related

ENSP00000367623.3, ENST00000378372.8

Conserved Domains (1) summary

cd10238
Location:2 → 376

HSPA14-like_NBD; Nucleotide-binding domain of human HSPA14 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

14838306..14871741

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

14852271..14885706

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001037538.1: Suppressed sequence

Description

NM_001037538.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_001278205.1: Suppressed sequence

Description

NM_001278205.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
NR_103464.2: Suppressed sequence

Description

NR_103464.2: This RefSeq was removed because it is thought that this transcript better represents a distinct gene, GeneID: 100421372.