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AIG1 androgen induced 1 [ Homo sapiens (human) ]

Gene ID: 51390, updated on 7-Apr-2024

Summary

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Official Symbol
AIG1provided by HGNC
Official Full Name
androgen induced 1provided by HGNC
Primary source
HGNC:HGNC:21607
See related
Ensembl:ENSG00000146416 MIM:608514; AllianceGenome:HGNC:21607
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIG-1; dJ95L4.1
Summary
Enables hydrolase activity. Involved in long-chain fatty acid catabolic process. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver (RPKM 13.8), kidney (RPKM 9.3) and 24 other tissues See more
Orthologs
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Genomic context

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See AIG1 in Genome Data Viewer
Location:
6q24.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (143059213..143343883)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (144251637..144536274)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (143380350..143665020)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17621 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25189 Neighboring gene HIVEP2 divergent transcript Neighboring gene long intergenic non-protein coding RNA 1277 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:143323875-143325074 Neighboring gene MPRA-validated peak6176 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25191 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:143381022-143381960 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25193 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25194 Neighboring gene uncharacterized LOC124901416 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:143497835-143498335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25195 Neighboring gene Sharpr-MPRA regulatory region 5457 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:143609782-143610665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25196 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:143654104-143655303 Neighboring gene ribosomal protein L31 pseudogene 27 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25197 Neighboring gene uncharacterized LOC107986656 Neighboring gene PARL pseudogene 2 Neighboring gene C4orf46 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25198 Neighboring gene adenosine deaminase tRNA specific 2 Neighboring gene tubulin beta 8 class VIII pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. AIG1 affects in vitro and in vivo virulence in clinical isolates of Entamoeba histolytica. Nakada-Tsukui K, et al. PLoS Pathog, 2018 Mar. PMID 29554130, Free PMC Article
  2. Cloning of androgen-inducible gene 1 (AIG1) from human dermal papilla cells. Seo J, et al. Mol Cells, 2001 Feb 28. PMID 11266118
  3. AIG1 is a novel Pirh2-interacting protein that activates the NFAT signaling pathway. Wu G, et al. Front Biosci (Elite Ed), 2011 Jun 1. PMID 21622095
  4. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Parsons WH, et al. Nat Chem Biol, 2016 May. PMID 27018888, Free PMC Article
  5. Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia. Ellinghaus E, et al. Leukemia, 2012 May. PMID 22076464, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High AIG1 expression is associated with virulence in clinical isolates of Entamoeba histolytica.
    Title: AIG1 affects in vitro and in vivo virulence in clinical isolates of Entamoeba histolytica.
  2. These results indicate that AIG1 and ADTRP are founding members of an evolutionarily conserved class of transmembrane threonine hydrolases involved in bioactive lipid metabolism.
    Title: AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs.
  3. identified a novel Pirh2-interacting protein, AIG1, by yeast two-hybrid screening and confirmed its interaction with p53 both in vitro and in vivo
    Title: AIG1 is a novel Pirh2-interacting protein that activates the NFAT signaling pathway.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10485, DKFZp686F03136

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in long-chain fatty acid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
androgen-induced gene 1 protein
Names
FAHFA hydrolase AIG1
fatty acid esters of hydroxy fatty acids hydrolase AIG1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286587.2 → NP_001273516.1  androgen-induced gene 1 protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AF151861, AL023581, AL136116, BC025278, BG196820
    UniProtKB/TrEMBL
    Q53HV5
    Conserved Domains (1) summary
    pfam04750
    Location:2 → 209
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  2. NM_001286588.2 → NP_001273517.1  androgen-induced gene 1 protein isoform c

    See identical proteins and their annotated locations for NP_001273517.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' exons but contains an alternate 3' exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK298533, AL023581, BX640703, CA431282, DB154031
    Consensus CDS
    CCDS69215.1
    UniProtKB/Swiss-Prot
    Q9NVV5
    Related
    ENSP00000485875.1, ENST00000629020.2
    Conserved Domains (1) summary
    pfam04750
    Location:12 → 133
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  3. NM_001286589.2 → NP_001273518.1  androgen-induced gene 1 protein isoform d

    See identical proteins and their annotated locations for NP_001273518.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks multiple 3' exons but contains an alternate 3' exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK298533, BX640703, CA431282
    Consensus CDS
    CCDS69216.1
    UniProtKB/Swiss-Prot
    Q9NVV5
    Related
    ENSP00000473952.1, ENST00000494282.6
    Conserved Domains (1) summary
    pfam04750
    Location:12 → 134
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  4. NM_001363721.2 → NP_001350650.1  androgen-induced gene 1 protein isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (e) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL023581, AL136116, AL391726
    Consensus CDS
    CCDS87450.1
    UniProtKB/TrEMBL
    A0A2R8YCJ8, Q53HV5
    Related
    ENSP00000493676.1, ENST00000646199.1
    Conserved Domains (1) summary
    pfam04750
    Location:12 → 219
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  5. NM_001366344.1 → NP_001353273.1  androgen-induced gene 1 protein isoform f precursor

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    UniProtKB/TrEMBL
    Q53HV5
    Conserved Domains (1) summary
    pfam04750
    Location:12 → 266
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  6. NM_001366345.1 → NP_001353274.1  androgen-induced gene 1 protein isoform g

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    UniProtKB/TrEMBL
    Q53HV5
    Conserved Domains (1) summary
    pfam04750
    Location:36 → 243
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  7. NM_001366346.1 → NP_001353275.1  androgen-induced gene 1 protein isoform h

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    UniProtKB/TrEMBL
    Q53HV5
    Conserved Domains (1) summary
    pfam04750
    Location:12 → 219
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  8. NM_001366347.1 → NP_001353276.1  androgen-induced gene 1 protein isoform i

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    Consensus CDS
    CCDS94014.1
    UniProtKB/TrEMBL
    Q53HV5
    Related
    ENSP00000275235.4, ENST00000275235.8
    Conserved Domains (1) summary
    pfam04750
    Location:12 → 219
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  9. NM_001366348.1 → NP_001353277.1  androgen-induced gene 1 protein isoform j

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    UniProtKB/TrEMBL
    Q53HV5
    Conserved Domains (1) summary
    pfam04750
    Location:12 → 219
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  10. NM_001366349.2 → NP_001353278.1  androgen-induced gene 1 protein isoform k

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    UniProtKB/TrEMBL
    Q53HV5
    Conserved Domains (1) summary
    pfam04750
    Location:12 → 219
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  11. NM_001366350.1 → NP_001353279.1  androgen-induced gene 1 protein isoform l

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    UniProtKB/TrEMBL
    Q53HV5
    Conserved Domains (1) summary
    pfam04750
    Location:12 → 219
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  12. NM_001366351.1 → NP_001353280.1  androgen-induced gene 1 protein isoform m

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    UniProtKB/TrEMBL
    Q53HV5
    Related
    ENSP00000356573.4, ENST00000367601.8
    Conserved Domains (1) summary
    pfam04750
    Location:8 → 215
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  13. NM_001366352.1 → NP_001353281.1  androgen-induced gene 1 protein isoform n

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    Conserved Domains (1) summary
    pfam04750
    Location:36 → 157
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  14. NM_001366353.1 → NP_001353282.1  androgen-induced gene 1 protein isoform o

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116
    UniProtKB/TrEMBL
    Q53HV5
    Conserved Domains (1) summary
    pfam04750
    Location:12 → 185
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  15. NM_001366354.1 → NP_001353283.1  androgen-induced gene 1 protein isoform p

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    Conserved Domains (1) summary
    pfam04750
    Location:12 → 133
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  16. NM_001366355.1 → NP_001353284.1  androgen-induced gene 1 protein isoform q

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    Conserved Domains (1) summary
    pfam04750
    Location:12 → 167
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  17. NM_001366356.2 → NP_001353285.1  androgen-induced gene 1 protein isoform r precursor

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL391726
    Conserved Domains (1) summary
    pfam04750
    Location:12 → 181
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  18. NM_001366357.1 → NP_001353286.1  androgen-induced gene 1 protein isoform s

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    UniProtKB/TrEMBL
    Q5T2H4
    Conserved Domains (1) summary
    pfam04750
    Location:12 → 172
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  19. NM_001366358.1 → NP_001353287.1  androgen-induced gene 1 protein isoform t

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726
    UniProtKB/TrEMBL
    Q5T2H0
    Related
    ENSP00000407817.1, ENST00000458219.1
    Conserved Domains (1) summary
    pfam04750
    Location:1 → 131
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  20. NM_001366359.2 → NP_001353288.1  androgen-induced gene 1 protein isoform u

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL391726
    Conserved Domains (1) summary
    pfam04750
    Location:8 → 130
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  21. NM_001366361.1 → NP_001353290.1  androgen-induced gene 1 protein isoform v

    Status: VALIDATED

    Source sequence(s)
    AL136116, AL391726
    UniProtKB/TrEMBL
    Q5T2H0
    Conserved Domains (1) summary
    pfam04750
    Location:1 → 105
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  22. NM_001366362.1 → NP_001353291.1  androgen-induced gene 1 protein isoform w

    Status: VALIDATED

    Source sequence(s)
    AL023581
    Conserved Domains (1) summary
    pfam04750
    Location:36 → 71
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  23. NM_001366363.1 → NP_001353292.1  androgen-induced gene 1 protein isoform x

    Status: VALIDATED

    Source sequence(s)
    AL023581
    Consensus CDS
    CCDS94013.1
    UniProtKB/TrEMBL
    Q5THU2
    Related
    ENSP00000356568.1, ENST00000367596.5
    Conserved Domains (1) summary
    pfam04750
    Location:12 → 47
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  24. NM_016108.4 → NP_057192.2  androgen-induced gene 1 protein isoform a

    See identical proteins and their annotated locations for NP_057192.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AK298533, AL136116, BC025278, BG196820
    Consensus CDS
    CCDS5198.1
    UniProtKB/Swiss-Prot
    B4DPX2, C9J569, Q5T2H2, Q6N047, Q7Z378, Q8TB14, Q9NVV5, Q9Y3A9, Q9Y5B4
    UniProtKB/TrEMBL
    Q53HV5
    Related
    ENSP00000350509.4, ENST00000357847.9
    Conserved Domains (1) summary
    pfam04750
    Location:12 → 219
    Far-17a_AIG1; FAR-17a/AIG1-like protein

RNA

  1. NR_158896.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726

  2. NR_158960.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL023581, AL136116, AL391726

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    143059213..143343883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    144251637..144536274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NVV5.3 GenPept UniProtKB/Swiss-Prot:Q9NVV5

Gene LinkOut

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