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PDE4D phosphodiesterase 4D [ Homo sapiens (human) ]

Gene ID: 5144, updated on 5-Jan-2025

Summary

Official Symbol
PDE4Dprovided by HGNC
Official Full Name
phosphodiesterase 4Dprovided by HGNC
Primary source
HGNC:HGNC:8783
See related
Ensembl:ENSG00000113448 MIM:600129; AllianceGenome:HGNC:8783
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2
Summary
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
Expression
Broad expression in bone marrow (RPKM 7.8), lung (RPKM 3.1) and 20 other tissues See more
Orthologs
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Genomic context

See PDE4D in Genome Data Viewer
Location:
5q11.2-q12.1
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (58969038..60522128, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (59787596..61345916, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (58264865..59792113, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:57839100-57840299 Neighboring gene NANOG hESC enhancer GRCh37_chr5:57858257-57858782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16034 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86582 Neighboring gene long intergenic non-protein coding RNA 2108 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86593 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:58013208-58014189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16035 Neighboring gene RAB3C, member RAS oncogene family Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86681 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:58186496-58187695 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:58232852-58233452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:58233453-58234051 Neighboring gene Sharpr-MPRA regulatory region 1719 Neighboring gene ribosomal protein L5 pseudogene 15 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:58276599-58277183 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:58298739-58299634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16036 Neighboring gene MPRA-validated peak5258 silencer Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:58422602-58423512 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:58423513-58424422 Neighboring gene MPRA-validated peak5260 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr5:58454460-58454961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16037 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:58624407-58625606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:58690566-58691066 Neighboring gene uncharacterized LOC107986347 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:58858724-58859374 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:59004928-59005660 Neighboring gene Sharpr-MPRA regulatory region 14831 Neighboring gene MPRA-validated peak5261 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:59063568-59064767 Neighboring gene uncharacterized LOC105378988 Neighboring gene NANOG hESC enhancer GRCh37_chr5:59096304-59096834 Neighboring gene uncharacterized LOC107986350 Neighboring gene NANOG hESC enhancer GRCh37_chr5:59165165-59165666 Neighboring gene microRNA 582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:59345282-59345782 Neighboring gene NANOG hESC enhancer GRCh37_chr5:59657334-59657835 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:59666235-59667434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22584 Neighboring gene RNA, U6 small nuclear 806, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:59710708-59711366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22585 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22587 Neighboring gene Sharpr-MPRA regulatory region 9229 Neighboring gene ribosomal protein L31 pseudogene 8 Neighboring gene SET pseudogene 21 Neighboring gene Sharpr-MPRA regulatory region 1909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16038 Neighboring gene uncharacterized LOC124900982 Neighboring gene prostate androgen-regulated transcript 1 Neighboring gene DEP domain containing 1B Neighboring gene calcium binding protein 39 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Acrodysostosis 2 with or without hormone resistance
MedGen: C3553250 OMIM: 614613 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2018-02-02)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2018-02-02)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
A whole genome association study of neuroticism using DNA pooling.
EBI GWAS Catalog
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
EBI GWAS Catalog
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.
EBI GWAS Catalog
Genome-wide association of sleep and circadian phenotypes.
EBI GWAS Catalog
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
EBI GWAS Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
EBI GWAS Catalog
Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment.
EBI GWAS Catalog
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
EBI GWAS Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Cyclic AMP phosphodiesterase inhibitors AV411 and AV1013 inhibit HIV-1 replication and block HIV-1 Tat-induced neurotoxicity in human microglia, suggesting that cyclic AMP phosphodiesterase is involved in the Tat-mediated neurotoxicity PubMed
tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ97311, DKFZp686M11213

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity  
enables 3',5'-cyclic-AMP phosphodiesterase activity PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity  
enables 3',5'-cyclic-AMP phosphodiesterase activity  
enables 3',5'-cyclic-GMP phosphodiesterase activity  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity PubMed 
enables ATPase binding PubMed 
enables beta-2 adrenergic receptor binding  
enables cAMP binding PubMed 
enables calcium channel regulator activity PubMed 
enables enzyme binding PubMed 
enables heterocyclic compound binding PubMed 
enables metal ion binding  
enables protein binding PubMed 
enables scaffold protein binding PubMed 
enables signaling receptor regulator activity  
enables transmembrane transporter binding PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway PubMed 
involved_in adrenergic receptor signaling pathway  
involved_in cAMP catabolic process  
involved_in cAMP-mediated signaling  
involved_in cellular response to cAMP PubMed 
involved_in cellular response to epinephrine stimulus PubMed 
involved_in establishment of endothelial barrier  
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
involved_in negative regulation of heart contraction PubMed 
involved_in negative regulation of peptidyl-serine phosphorylation PubMed 
involved_in negative regulation of relaxation of cardiac muscle  
involved_in positive regulation of heart rate  
involved_in positive regulation of interleukin-2 production PubMed 
involved_in positive regulation of interleukin-5 production PubMed 
involved_in positive regulation of type II interferon production PubMed 
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  
involved_in regulation of cardiac muscle cell contraction PubMed 
involved_in regulation of cell communication by electrical coupling involved in cardiac conduction PubMed 
involved_in regulation of heart rate PubMed 
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane  
part_of calcium channel complex PubMed 
located_in centrosome  
located_in cytosol PubMed 
located_in cytosol  
NOT located_in membrane PubMed 
located_in membrane PubMed 
located_in plasma membrane  
part_of voltage-gated calcium channel complex  

General protein information

Preferred Names
3',5'-cyclic-AMP phosphodiesterase 4D
Names
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
cAMP-specific phosphodiesterase PDE4D6
phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
testicular tissue protein Li 136
NP_001098101.1
NP_001159371.1
NP_001184147.1
NP_001184148.1
NP_001184149.1
NP_001184150.1
NP_001184151.1
NP_001184152.1
NP_001336170.1
NP_001336171.1
NP_001336172.1
NP_001351528.1
NP_001351529.1
NP_001351530.1
NP_001351531.1
NP_001351532.1
NP_001351533.1
NP_006194.2
XP_011541771.1
XP_011541775.1
XP_016865055.1
XP_016865056.1
XP_024301878.1
XP_024301880.1
XP_047273249.1
XP_047273250.1
XP_047273251.1
XP_047273252.1
XP_047273253.1
XP_047273254.1
XP_047273255.1
XP_047273256.1
XP_047273257.1
XP_054208753.1
XP_054208754.1
XP_054208755.1
XP_054208756.1
XP_054208757.1
XP_054208758.1
XP_054208759.1
XP_054208760.1
XP_054208761.1
XP_054208762.1
XP_054208763.1
XP_054208764.1
XP_054208765.1
XP_054208766.1
XP_054208767.1
XP_054208768.1
XP_054208769.1
XP_054208770.1
XP_054208771.1
XP_054208772.1
XP_054208773.1
XP_054208774.1
XP_054208775.1
XP_054208776.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027957.2 RefSeqGene

    Range
    635604..1560292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104631.2NP_001098101.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D4

    See identical proteins and their annotated locations for NP_001098101.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (PDE4D4, also known as isoform 1).
    Source sequence(s)
    AC027322, AC092343, BF197530, L20969
    Consensus CDS
    CCDS47213.1
    UniProtKB/Swiss-Prot
    O43433, Q08499, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q96HL4, Q9HCX7
    UniProtKB/TrEMBL
    A0A140VJR0
    Related
    ENSP00000345502.6, ENST00000340635.11
    Conserved Domains (1) summary
    pfam00233
    Location:461702
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  2. NM_001165899.2NP_001159371.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D7

    See identical proteins and their annotated locations for NP_001159371.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D7 (also known as isoform 3) has a shorter and distinct N-terminus, compared to isoform PDE4D4. Variants 3 and 13 both encode the same isoform (PDE4D7).
    Source sequence(s)
    AC092343, AY245866, BI492585, DB230503
    Consensus CDS
    CCDS54859.1
    UniProtKB/Swiss-Prot
    Q08499
    Related
    ENSP00000423094.2, ENST00000502484.6
    Conserved Domains (2) summary
    pfam00233
    Location:400641
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:162278
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  3. NM_001197218.2NP_001184147.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D5

    See identical proteins and their annotated locations for NP_001184147.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D5 (also known as isoform 4) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC027322, AC092343, AF012073, BF197530
    Consensus CDS
    CCDS56373.1
    UniProtKB/Swiss-Prot
    Q08499
    Related
    ENSP00000424852.1, ENST00000507116.6
    Conserved Domains (2) summary
    pfam00233
    Location:397638
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:159275
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  4. NM_001197219.2NP_001184148.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D8

    See identical proteins and their annotated locations for NP_001184148.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D8 (also known as isoform 5) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC008791, AC092343, AF012073, AF536977, BF197530
    Consensus CDS
    CCDS56372.1
    UniProtKB/Swiss-Prot
    Q08499
    Related
    ENSP00000384806.2, ENST00000405755.6
    Conserved Domains (1) summary
    pfam00233
    Location:339576
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  5. NM_001197220.2NP_001184149.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D9

    See identical proteins and their annotated locations for NP_001184149.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D9 (also known as isoform 6) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC092343, AF012073, AY245867, BF197530
    Consensus CDS
    CCDS56371.1
    UniProtKB/Swiss-Prot
    Q08499
    Related
    ENSP00000425605.1, ENST00000503258.5
    Conserved Domains (2) summary
    pfam00233
    Location:331572
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:93209
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  6. NM_001197221.2NP_001184150.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D2

    See identical proteins and their annotated locations for NP_001184150.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D2 (also known as isoform 7) is shorter at the N-terminus, compared to isoform PDE4D4. Variants 7 and 17 both encode the same isoform (PDE4D2).
    Source sequence(s)
    AC092343, AF012074, BF197530
    Consensus CDS
    CCDS56370.1
    UniProtKB/TrEMBL
    D6RHE0
    Related
    ENSP00000351800.6, ENST00000358923.10
    Conserved Domains (2) summary
    pfam00233
    Location:159400
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:137
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  7. NM_001197222.2NP_001184151.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D1

    See identical proteins and their annotated locations for NP_001184151.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D1 (also known as isoform 8) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC092343, AF012074, BF197530, U50157
    UniProtKB/Swiss-Prot
    Q08499
    Conserved Domains (1) summary
    pfam00233
    Location:237478
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  8. NM_001197223.2NP_001184152.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D6

    See identical proteins and their annotated locations for NP_001184152.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D6 (also known as isoform 9) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC092343, AF536975, BC036319, BF197530
    Consensus CDS
    CCDS56369.1
    UniProtKB/TrEMBL
    D6RHE0
    Related
    ENSP00000321739.8, ENST00000317118.12
    Conserved Domains (2) summary
    pfam00233
    Location:170411
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:1648
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  9. NM_001349241.2NP_001336170.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and coding region, compared to variant 1. Isoform 10 is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC091955, AC092343, AY245866, BI492585, DB230503
    Conserved Domains (2) summary
    pfam00233
    Location:390631
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:152268
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  10. NM_001349242.2NP_001336171.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and coding region, compared to variant 1. Isoform 11 is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC008791, AC092343, AC117527, BF197530, L20970, U50159
    Consensus CDS
    CCDS87297.1
    UniProtKB/TrEMBL
    A0A1B0GW84
    Related
    ENSP00000490821.1, ENST00000636120.1
    Conserved Domains (2) summary
    pfam00233
    Location:351592
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:113229
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  11. NM_001349243.2NP_001336172.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR and coding region, compared to variant 1. Isoform 12 is shorter and has a distinct N-terminus, compared to isoform PDE4D4. Variants 12 and 18 both encode the same isoform (12).
    Source sequence(s)
    AC091955, AC092343, AY245866, BI492585, DB230503
    Conserved Domains (2) summary
    pfam00233
    Location:205446
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:183
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  12. NM_001364599.1NP_001351528.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variant 3, encodes isoform PDE4D7.
    Source sequence(s)
    AC008818, AC008829, AC008934, AC091955, AC092343
    Consensus CDS
    CCDS54859.1
    Conserved Domains (2) summary
    pfam00233
    Location:400641
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:162278
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  13. NM_001364600.2NP_001351529.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC008829, AC008934, AC091955, AC109486
  14. NM_001364601.1NP_001351530.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC008829, AC027322
  15. NM_001364602.2NP_001351531.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC008829, AC027322, BC008390
    Consensus CDS
    CCDS93714.1
    Related
    ENSP00000425917.1, ENST00000502575.1
    Conserved Domains (1) summary
    pfam18100
    Location:159204
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  16. NM_001364603.1NP_001351532.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 7, encodes isoform PDE4D2.
    Source sequence(s)
    AC027322, AC092343, AJ250854
    Consensus CDS
    CCDS56370.1
    UniProtKB/TrEMBL
    D6RHE0
    Conserved Domains (2) summary
    pfam00233
    Location:159400
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:137
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  17. NM_001364604.1NP_001351533.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variant 12, encodes isoform 12.
    Source sequence(s)
    AC008829, AC092343, AC117527
    Conserved Domains (2) summary
    pfam00233
    Location:205446
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:183
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  18. NM_006203.5NP_006194.2  3',5'-cyclic-AMP phosphodiesterase 4D isoform PDE4D3

    See identical proteins and their annotated locations for NP_006194.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D3 (also known as isoform 2) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC092343, AC117527, BF197530, L20970, U50159
    Consensus CDS
    CCDS54858.1
    UniProtKB/Swiss-Prot
    Q08499
    Related
    ENSP00000353152.5, ENST00000360047.9
    Conserved Domains (2) summary
    pfam00233
    Location:325566
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:87203
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    58969038..60522128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446112.2XP_024301880.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

    Conserved Domains (2) summary
    pfam00233
    Location:400641
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:162278
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  2. XM_024446110.2XP_024301878.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

    Conserved Domains (1) summary
    pfam00233
    Location:449686
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  3. XM_047417295.1XP_047273251.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X4

  4. XM_017009566.1XP_016865055.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

    UniProtKB/Swiss-Prot
    Q08499
    Conserved Domains (2) summary
    pfam00233
    Location:400641
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:162278
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  5. XM_047417294.1XP_047273250.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

  6. XM_011543473.2XP_011541775.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

    See identical proteins and their annotated locations for XP_011541775.1

    UniProtKB/Swiss-Prot
    Q08499
    Conserved Domains (2) summary
    pfam00233
    Location:400641
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:162278
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  7. XM_047417293.1XP_047273249.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

  8. XM_011543469.2XP_011541771.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

    See identical proteins and their annotated locations for XP_011541771.1

    Conserved Domains (1) summary
    pfam00233
    Location:449686
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  9. XM_017009567.1XP_016865056.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X3

    Conserved Domains (2) summary
    pfam00233
    Location:395636
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:157273
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  10. XM_047417297.1XP_047273253.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X6

  11. XM_047417296.1XP_047273252.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X5

  12. XM_047417298.1XP_047273254.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X7

  13. XM_047417299.1XP_047273255.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X7

  14. XM_047417301.1XP_047273257.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X9

  15. XM_047417300.1XP_047273256.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    59787596..61345916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352788.1XP_054208763.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

  2. XM_054352780.1XP_054208755.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

  3. XM_054352789.1XP_054208764.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

  4. XM_054352790.1XP_054208765.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

  5. XM_054352793.1XP_054208768.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

  6. XM_054352782.1XP_054208757.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

  7. XM_054352781.1XP_054208756.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

  8. XM_054352783.1XP_054208758.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

  9. XM_054352785.1XP_054208760.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

  10. XM_054352792.1XP_054208767.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

  11. XM_054352795.1XP_054208770.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X4

  12. XM_054352784.1XP_054208759.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

  13. XM_054352778.1XP_054208753.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

  14. XM_054352787.1XP_054208762.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

  15. XM_054352791.1XP_054208766.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

  16. XM_054352779.1XP_054208754.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

  17. XM_054352786.1XP_054208761.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

  18. XM_054352794.1XP_054208769.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X3

  19. XM_054352799.1XP_054208774.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X6

  20. XM_054352798.1XP_054208773.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X5

  21. XM_054352797.1XP_054208772.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X5

  22. XM_054352796.1XP_054208771.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X10

  23. XM_054352800.1XP_054208775.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X7

  24. XM_054352801.1XP_054208776.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X8

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