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GPR89B G protein-coupled receptor 89B [ Homo sapiens (human) ]

Gene ID: 51463, updated on 3-Apr-2024

Summary

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Official Symbol
GPR89Bprovided by HGNC
Official Full Name
G protein-coupled receptor 89Bprovided by HGNC
Primary source
HGNC:HGNC:13840
See related
Ensembl:ENSG00000188092 MIM:612806; AllianceGenome:HGNC:13840
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPHR; GPR89; SH120; GPR89C; UNQ192; LINC02804
Summary
Enables voltage-gated anion channel activity. Involved in intracellular pH reduction. Located in Golgi cisterna membrane and Golgi-associated vesicle membrane. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: There are multiple copies of the sequence G protein-coupled receptor 89 in the human genome. After consultation with the HUGO Gene Nomenclature committee, the symbol GPR89B was assigned to the most telomeric locus. [06 Jun 2007]
Expression
Ubiquitous expression in kidney (RPKM 17.6), testis (RPKM 13.4) and 25 other tissues See more
Orthologs
all
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Genomic context

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See GPR89B in Genome Data Viewer
Location:
1q21.2
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (147928420..148025934)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (146781476..146879130, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (147400533..147465824)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371229 Neighboring gene gap junction protein alpha 8 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:147420827-147421344 Neighboring gene PDZ domain containing 1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145943675-145944386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145944387-145945098 Neighboring gene tRNA-Arg (anticodon CCT) 6-2 Neighboring gene RNA, U1 small nuclear 129, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:145963909-145964683 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:147510508-147511043 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:147511044-147511580 Neighboring gene tRNA-Gln (anticodon CTG) 3-2 Neighboring gene RNA, variant U1 small nuclear 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. Maeda Y, et al. Nat Cell Biol, 2008 Oct. PMID 18794847
  2. Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development. Van Alstyne M, et al. Biochem Biophys Res Commun, 2018 Nov 30. PMID 30352685, Free PMC Article
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Lai CH, et al. Genome Res, 2000 May. PMID 10810093, Free PMC Article
  4. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501
  5. Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network. Kattan RE, et al. Mol Cell Proteomics, 2022 Feb. PMID 35007762, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ55546, FLJ61382

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables voltage-gated monoatomic anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular pH reduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi cisterna membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Golgi pH regulator B
Names
G protein-coupled receptor 89C
Golgi pH regulator A
long intergenic non-protein coding RNA 2804
protein GPR89
putative Golgi pH regulator C
putative MAPK-activating protein PM01
putative NF-kappa-B-activating protein 90
putative protein GPR89C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001350180.2 → NP_001337109.1  Golgi pH regulator B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon structure in the 3' region compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AL133020, AW002571, AW137222, DB524598, U78723
    Consensus CDS
    CCDS930.1
    UniProtKB/Swiss-Prot
    A6NKF9, A6NN37, B2RUV3, B3KMN3, B4DLT3, B4DXE7, B7ZAQ6, P0CG08, Q53FQ9, Q5T2V8, Q5T5P5, Q659E2, Q6NVY5, Q9P0S4, Q9Y302
    UniProtKB/TrEMBL
    X5D7G6, X5D920
    Conserved Domains (2) summary
    pfam12430
    Location:276 → 446
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:140 → 207
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

  2. NM_001350181.2 → NP_001337110.1  Golgi pH regulator B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in its 5' region, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 3 and 4 encode the same protein (isoform 2).
    Source sequence(s)
    AL133020, AW002571, AW137222, DB459108, DC412954, U78723
    UniProtKB/TrEMBL
    X5D920
    Conserved Domains (2) summary
    pfam12430
    Location:251 → 419
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:115 → 182
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

  3. NM_001350182.2 → NP_001337111.1  Golgi pH regulator B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in its 5' region, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 3 and 4 encode the same protein (isoform 2).
    Source sequence(s)
    AL133020, AW002571, AW137222, DC345007, DC412954, U78723
    UniProtKB/TrEMBL
    X5D920
    Conserved Domains (2) summary
    pfam12430
    Location:251 → 419
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:115 → 182
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

  4. NM_001350183.2 → NP_001337112.1  Golgi pH regulator B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in its 5' region, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 4 and 5 encode the same protein (isoform 3).
    Source sequence(s)
    AL133020, AW002571, AW137222, DA922006, DC412954, U78723
    UniProtKB/TrEMBL
    B4DY51
    Conserved Domains (2) summary
    pfam12430
    Location:156 → 324
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:20 → 87
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

  5. NM_001350184.2 → NP_001337113.1  Golgi pH regulator B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate exon and uses an alternate splice site in its 5' region, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 4 and 5 encode the same protein (isoform 3)
    Source sequence(s)
    AL133020, AW002571, AW137222, DA065783, DA922006, U78723
    UniProtKB/TrEMBL
    B4DY51
    Conserved Domains (2) summary
    pfam12430
    Location:156 → 324
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:20 → 87
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

  6. NM_016334.5 → NP_057418.1  Golgi pH regulator B isoform 1

    See identical proteins and their annotated locations for NP_057418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AL133020, AW002571, AW137222, U78723
    Consensus CDS
    CCDS930.1
    UniProtKB/Swiss-Prot
    A6NKF9, A6NN37, B2RUV3, B3KMN3, B4DLT3, B4DXE7, B7ZAQ6, P0CG08, Q53FQ9, Q5T2V8, Q5T5P5, Q659E2, Q6NVY5, Q9P0S4, Q9Y302
    UniProtKB/TrEMBL
    X5D7G6, X5D920
    Related
    ENSP00000358233.4, ENST00000314163.12
    Conserved Domains (2) summary
    pfam12430
    Location:276 → 446
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:140 → 207
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

RNA

  1. NR_183755.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC239801, AC239803

  2. NR_183756.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC239801, AC239803

  3. NR_183757.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC239801, AC239803

  4. NR_183758.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC239801, AC239803

  5. NR_183759.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC239801, AC239803

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    147928420..148025934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422467.1 → XP_047278423.1  Golgi pH regulator B isoform X2

  2. XM_017001449.2 → XP_016856938.1  Golgi pH regulator B isoform X3

    UniProtKB/TrEMBL
    X5D9J6
    Related
    ENSP00000475253.1, ENST00000468618.6

  3. XM_005277402.5 → XP_005277459.1  Golgi pH regulator B isoform X1

    See identical proteins and their annotated locations for XP_005277459.1

    UniProtKB/TrEMBL
    X5D920
    Conserved Domains (2) summary
    pfam12430
    Location:251 → 419
    ABA_GPCR; Abscisic acid G-protein coupled receptor
    pfam12537
    Location:115 → 182
    GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

RNA

  1. XR_007060778.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    146781476..146879130 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336966.1 → XP_054192941.1  Golgi pH regulator B isoform X1

  2. XM_054336968.1 → XP_054192943.1  Golgi pH regulator B isoform X3

  3. XM_054336967.1 → XP_054192942.1  Golgi pH regulator B isoform X2

RNA

  1. XR_008486065.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001097616.1: Suppressed sequence

    Description
    NM_001097616.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CG08.1 GenPept UniProtKB/Swiss-Prot:P0CG08

Gene LinkOut

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