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ACKR4 atypical chemokine receptor 4 [ Homo sapiens (human) ]

Gene ID: 51554, updated on 11-Apr-2024

Summary

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Official Symbol
ACKR4provided by HGNC
Official Full Name
atypical chemokine receptor 4provided by HGNC
Primary source
HGNC:HGNC:1611
See related
Ensembl:ENSG00000129048 MIM:606065; AllianceGenome:HGNC:1611
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPR1; CCBP2; CCR10; CCR11; CCRL1; VSHK1; CCR-11; CKR-11; CCX CKR; CCX-CKR; CC-CKR-11
Summary
The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013]
Expression
Broad expression in duodenum (RPKM 8.4), small intestine (RPKM 7.1) and 16 other tissues See more
Orthologs
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Genomic context

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See ACKR4 in Genome Data Viewer
Location:
3q22.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (132597270..132602644)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (135341777..135347152)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (132316114..132321488)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14741 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:132136675-132137210 Neighboring gene DnaJ heat shock protein family (Hsp40) member C13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:132190883-132191410 Neighboring gene uncharacterized LOC124909436 Neighboring gene NPHP3-ACAD11 readthrough (NMD candidate) Neighboring gene acyl-CoA dehydrogenase family member 11 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:132337002-132338201 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14742 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:132345519-132346020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:132346021-132346520 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:132348758-132349957 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:132360104-132360294 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:132378955-132379493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20539 Neighboring gene heat shock protein family A (Hsp70) member pseudogene 19 Neighboring gene ubiquitin like modifier activating enzyme 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins. Matti C, et al. Front Immunol, 2020. PMID 32391018, Free PMC Article
  2. Endogenous expression of the atypical chemokine receptor CCX-CKR (CCRL1) gene in human embryonic kidney (HEK 293) cells. Salimi P, et al. Mol Cell Biochem, 2016 Jan. PMID 26699909
  3. CCX-CKR expression in colorectal cancer and patient survival. Zhu Y, et al. Int J Biol Markers, 2014 Mar 24. PMID 24338720
  4. Involvement of a novel chemokine decoy receptor CCX-CKR in breast cancer growth, metastasis and patient survival. Feng LY, et al. Clin Cancer Res, 2009 May 1. PMID 19383822
  5. The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro. Comerford I, et al. Eur J Immunol, 2006 Jul. PMID 16791897

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension.
    Title: Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension.
  2. Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics.
    Title: Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics.
  3. The relation between ACKR4 and CCR7 genes expression and breast cancer metastasis.
    Title: The relation between ACKR4 and CCR7 genes expression and breast cancer metastasis.
  4. Biphasic Expression of Atypical Chemokine Receptor (ACKR) 2 and ACKR4 in Colorectal Neoplasms in Association with Histopathological Findings.
    Title: Biphasic Expression of Atypical Chemokine Receptor (ACKR) 2 and ACKR4 in Colorectal Neoplasms in Association with Histopathological Findings.
  5. ACKR4 Recruits GRK3 Prior to beta-Arrestins but Can Scavenge Chemokines in the Absence of beta-Arrestins.
    Title: ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins.
  6. Systematic reassessment of chemokine-receptor pairings confirms CCL20 but not CXCL13 and extends the spectrum of ACKR4 agonists to CCL22.
    Title: Systematic reassessment of chemokine-receptor pairings confirms CCL20 but not CXCL13 and extends the spectrum of ACKR4 agonists to CCL22.
  7. CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4.
    Title: CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4.
  8. CCL19-mRFP and CCL21-mRFP are versatile and powerful tools to study CCR7 and ACKR4 functions.
    Title: Fluorescently Tagged CCL19 and CCL21 to Monitor CCR7 and ACKR4 Functions.
  9. Results of this study show that HEK 293 cells express an endogenous CCRL1 gene only at mRNA level. These data therefore represent the important implications for the use of HEK 293 cells as a host cell system for the study of CCX-CKR.
    Title: Endogenous expression of the atypical chemokine receptor CCX-CKR (CCRL1) gene in human embryonic kidney (HEK 293) cells.
  10. we found that CCX-CKR expression in vitro could modulate cellular migration and invasion abilities, potentially via the regulation of other chemotactic factors/receptors.
    Title: CCX-CKR expression in colorectal cancer and patient survival.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
EBI GWAS Catalog
Genetic variation associated with circulating monocyte count in the eMERGE Network.
EBI GWAS Catalog
Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chemokine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis TAS
Traceable Author Statement
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
atypical chemokine receptor 4
Names
C-C CKR-11
C-C chemokine receptor type 11
CC chemokine receptor-like 1
chemocentryx chemokine receptor
chemokine (C-C motif) receptor-like 1
chemokine, cc motif, receptor-like protein 1
orphan seven-transmembrane receptor, chemokine related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016557.4 → NP_057641.1  atypical chemokine receptor 4

    See identical proteins and their annotated locations for NP_057641.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, as compared to variant 1. Both variants encode the some protein.
    Source sequence(s)
    AF110640, AK225927, BQ015927, DC419249
    Consensus CDS
    CCDS3075.1
    UniProtKB/Swiss-Prot
    B2R9U7, Q9NPB9
    UniProtKB/TrEMBL
    Q4VBN4
    Related
    ENSP00000249887.2, ENST00000249887.3
    Conserved Domains (1) summary
    cd15176
    Location:42 → 314
    7tmA_ACKR4_CCR11; atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_178445.2 → NP_848540.1  atypical chemokine receptor 4

    See identical proteins and their annotated locations for NP_848540.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, as compared to variant 2. Both variants encode the same protein.
    Source sequence(s)
    AC020632
    Consensus CDS
    CCDS3075.1
    UniProtKB/Swiss-Prot
    B2R9U7, Q9NPB9
    UniProtKB/TrEMBL
    Q4VBN4
    Conserved Domains (1) summary
    cd15176
    Location:42 → 314
    7tmA_ACKR4_CCR11; atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    132597270..132602644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    135341777..135347152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NPB9.1 GenPept UniProtKB/Swiss-Prot:Q9NPB9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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