CAB39 calcium binding protein 39 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CAB39provided by HGNC
Official Full Name: calcium binding protein 39provided by HGNC
Primary source: HGNC:HGNC:20292
See related: Ensembl:ENSG00000135932 MIM:612174; AllianceGenome:HGNC:20292
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MO25; CGI-66
Summary: Enables kinase binding activity and protein serine/threonine kinase activator activity. Involved in intracellular signal transduction; peptidyl-serine phosphorylation; and positive regulation of protein phosphorylation. Located in extracellular exosome. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma and pancreatic cancer. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon (RPKM 18.8), appendix (RPKM 18.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q37.1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (230712842..230821075)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (231195928..231304198)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (231577557..231685790)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway.
Title: CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway.
miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity.
Title: miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity.
MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39.
Title: MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39.
miR-1265 suppresses gastric cancer progression and oncogenic autophagy by reducing CAB39 expression and regulating the AMPK-mTOR signaling pathway.
Title: MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy.
The MO25 binding to SPAK and OSR1 is enhanced by serine phosphorylation in their highly conserved WEWS motif, which is located in their C-terminal domains.
Title: C-terminal phosphorylation of SPAK and OSR1 kinases promotes their binding and activation by the scaffolding protein MO25.
Upregulation of miR-451 expression suppressed the growth and invasion of glioma cells in vitro and in vivo by targeting CAB39 and modulating the mTOR/HIF-1a/VEGF signaling pathway.
Title: MiRNA-451 Inhibits Glioma Cell Proliferation and Invasion Through the mTOR/HIF-1α/VEGF Signaling Pathway by Targeting CAB39.
plays very important oncogenic roles in hepatocellular carcinoma pathogenesis and progression by activating the ERK signaling pathway
Title: Calcium-binding protein 39 promotes hepatocellular carcinoma growth and metastasis by activating extracellular signal-regulated kinase signaling pathway.
These data provide molecular understanding of the mechanism by which MO25 isoforms regulates the activity of STE20 family protein kinases.
Title: Structural insights into the activation of MST3 by MO25.
Authors conclude that miR-451 represses glioma in vitro and in vivo, likely through targeting CAB39 directly and inhibiting the PI3K/AKT pathway indirectly.
Title: MicroRNA miR-451 downregulates the PI3K/AKT pathway through CAB39 in human glioma.
MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases.
Title: MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH46522 (e-PCR)
- UniSTS:59671

NIB1194 (e-PCR)
- UniSTS:21349

SHGC-81194 (e-PCR)
- UniSTS:102018

D2S1575E (e-PCR)
- UniSTS:150659

G06903 (e-PCR)
- UniSTS:1421

D2S2340 (e-PCR)
- UniSTS:4251

RH68250 (e-PCR)
- UniSTS:52680

RH69702 (e-PCR)
- UniSTS:85705

RH94102 (e-PCR)
- UniSTS:84689

WI-17440 (e-PCR)
- UniSTS:6366

A002Q38 (e-PCR)
- UniSTS:60389

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular hypotonic response	IC Inferred by Curator more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of potassium ion transmembrane transport	IC Inferred by Curator more info	PubMed
involved_in negative regulation of potassium ion transmembrane transporter activity	IC Inferred by Curator more info	PubMed
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in response to activity	IEA Inferred from Electronic Annotation more info
involved_in response to thyroid hormone	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
located_in secretory granule lumen	TAS Traceable Author Statement more info
part_of serine/threonine protein kinase complex	IC Inferred by Curator more info	PubMed
part_of serine/threonine protein kinase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of serine/threonine protein kinase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: calcium-binding protein 39

Names: MO25alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130849.2 → NP_001124321.1 calcium-binding protein 39

See identical proteins and their annotated locations for NP_001124321.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents an alternate non-coding exon in the 5'UTR compared to variant 1. The same protein is encoded by variants 1, 2, and 3.

Source sequence(s)

AF113536, AK000804, AK292382

Consensus CDS

CCDS2478.1

UniProtKB/Swiss-Prot

A8K8L7, Q9Y376

UniProtKB/TrEMBL

Q7Z4X0

Related

ENSP00000386238.3, ENST00000409788.7

Conserved Domains (1) summary

pfam08569
Location:5 → 334

Mo25; Mo25-like
NM_001130850.2 → NP_001124322.1 calcium-binding protein 39

See identical proteins and their annotated locations for NP_001124322.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents an alternate non-coding exon in the 5'UTR compared to variant 1. The same protein is encoded by variants 1, 2, and 3.

Source sequence(s)

AC084031, AF113536, AK000804, AK315692, DB455871

Consensus CDS

CCDS2478.1

UniProtKB/Swiss-Prot

A8K8L7, Q9Y376

UniProtKB/TrEMBL

Q7Z4X0

Related

ENSP00000386642.3, ENST00000410084.7

Conserved Domains (1) summary

pfam08569
Location:5 → 334

Mo25; Mo25-like
NM_016289.4 → NP_057373.1 calcium-binding protein 39

See identical proteins and their annotated locations for NP_057373.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents an alternate non-coding exon in the 5'UTR. The same protein is encoded by variants 1, 2, and 3.

Source sequence(s)

AF113536, AK000804, BC020570, BG773506, DA886579

Consensus CDS

CCDS2478.1

UniProtKB/Swiss-Prot

A8K8L7, Q9Y376

UniProtKB/TrEMBL

Q7Z4X0

Related

ENSP00000258418.5, ENST00000258418.10

Conserved Domains (1) summary

pfam08569
Location:5 → 334

Mo25; Mo25-like