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STK26 serine/threonine kinase 26 [ Homo sapiens (human) ]

Gene ID: 51765, updated on 11-Apr-2024

Summary

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Official Symbol
STK26provided by HGNC
Official Full Name
serine/threonine kinase 26provided by HGNC
Primary source
HGNC:HGNC:18174
See related
Ensembl:ENSG00000134602 MIM:300547; AllianceGenome:HGNC:18174
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MASK; MST4
Summary
The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Expression
Broad expression in endometrium (RPKM 22.0), bone marrow (RPKM 21.7) and 22 other tissues See more
Orthologs
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Genomic context

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Location:
Xq26.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (132023302..132075943)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (130347539..130400176)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (131157330..131209971)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene firre intergenic repeating RNA element Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:130937096-130937596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:130937597-130938097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29965 Neighboring gene Sharpr-MPRA regulatory region 13107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29967 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:130960090-130960590 Neighboring gene PNKD pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:131057048-131058247 Neighboring gene RNA, 5S ribosomal pseudogene 514 Neighboring gene Sharpr-MPRA regulatory region 3545 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:131156878-131157424 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:131157425-131157972 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21004 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:131253207-131254142 Neighboring gene FERM domain containing 7 Neighboring gene AGK pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The mammalian Sterile 20-like kinase 4 (MST4) signaling in tumor progression: Implications for therapy. Getu AA, et al. Cancer Lett, 2023 Jun 1. PMID 37094736, Free PMC Article
  2. MST4: A Potential Oncogene and Therapeutic Target in Breast Cancer. Arora R, et al. Cells, 2022 Dec 15. PMID 36552828, Free PMC Article
  3. Mammalian Ste20-like kinase 4 promotes pituitary cell proliferation and survival under hypoxia. Xiong W, et al. Mol Endocrinol, 2015 Mar. PMID 25650755, Free PMC Article
  4. MST4 promotes hepatocellular carcinoma epithelial-mesenchymal transition and metastasis via activation of the p-ERK pathway. Lin ZH, et al. Int J Oncol, 2014 Aug. PMID 24859810
  5. The Ste20 kinase MST4 plays a role in prostate cancer progression. Sung V, et al. Cancer Res, 2003 Jun 15. PMID 12810671

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages.
    Title: MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages.
  2. STE20-type kinases MST3 and MST4 promote the progression of hepatocellular carcinoma: Evidence from human cell culture and expression profiling of liver biopsies.
    Title: STE20-type kinases MST3 and MST4 promote the progression of hepatocellular carcinoma: Evidence from human cell culture and expression profiling of liver biopsies.
  3. The mammalian Sterile 20-like kinase 4 (MST4) signaling in tumor progression: Implications for therapy.
    Title: The mammalian Sterile 20-like kinase 4 (MST4) signaling in tumor progression: Implications for therapy.
  4. MST4: A Potential Oncogene and Therapeutic Target in Breast Cancer.
    Title: MST4: A Potential Oncogene and Therapeutic Target in Breast Cancer.
  5. An MST4-pbeta-Catenin(Thr40) Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis.
    Title: An MST4-pβ-Catenin(Thr40) Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis.
  6. A network-based variable selection approach for identification of modules and biomarker genes associated with end-stage kidney disease.
    Title: A network-based variable selection approach for identification of modules and biomarker genes associated with end-stage kidney disease.
  7. Tripartite motif containing 59 (TRIM59) promotes esophageal cancer progression via promoting MST4 expression and ERK pathway.
    Title: Tripartite motif containing 59 (TRIM59) promotes esophageal cancer progression via promoting MST4 expression and ERK pathway.
  8. MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway.
    Title: MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway.
  9. Downregulation of MST4 Underlies a Novel Inhibitory Role of MicroRNA Let-7a in the Progression of Retinoblastoma.
    Title: Downregulation of MST4 Underlies a Novel Inhibitory Role of MicroRNA Let-7a in the Progression of Retinoblastoma.
  10. MicroRNA-486-5p inhibits ovarian granulosa cell proliferation and participates in the development of PCOS via targeting MST4.
    Title: MicroRNA-486-5p inhibits ovarian granulosa cell proliferation and participates in the development of PCOS via targeting MST4.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microvillus assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi-associated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase 26
Names
Mst3 and SOK1-related kinase
STE20-like kinase 4
STE20-like kinase MST4
mammalian Ste20-like protein kinase 4
mammalian sterile 20-like 4
serine/threonine protein kinase 26
serine/threonine protein kinase MST4
serine/threonine-protein kinase MASK
NP_001035917.1
NP_001035918.1
NP_057626.2
XP_047298111.1
XP_047298112.1
XP_054183158.1
XP_054183159.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029562.1 RefSeqGene

    Range
    5086..57727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042452.2 → NP_001035917.1  serine/threonine-protein kinase 26 isoform 3

    See identical proteins and their annotated locations for NP_001035917.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (3) is shorter compared to isoform 1, and lacks kinase activity.
    Source sequence(s)
    AF344883, AL109749, BC070056
    Consensus CDS
    CCDS43995.1
    UniProtKB/TrEMBL
    Q499L9
    Related
    ENSP00000419702.1, ENST00000496850.1
    Conserved Domains (1) summary
    cl21453
    Location:19 → 233
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001042453.2 → NP_001035918.1  serine/threonine-protein kinase 26 isoform 2

    See identical proteins and their annotated locations for NP_001035918.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AK075107, BC070056, DA760264
    Consensus CDS
    CCDS48168.1
    UniProtKB/TrEMBL
    Q9NWX4
    Related
    ENSP00000377868.2, ENST00000394335.6
    Conserved Domains (1) summary
    cl21453
    Location:15 → 218
    PKc_like; Protein Kinases, catalytic domain

  3. NM_016542.4 → NP_057626.2  serine/threonine-protein kinase 26 isoform 1

    See identical proteins and their annotated locations for NP_057626.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF231012, BC070056, DA760264
    Consensus CDS
    CCDS14631.1
    UniProtKB/Swiss-Prot
    B2RAU2, Q3ZB77, Q8NC04, Q9BXC3, Q9BXC4, Q9P289
    UniProtKB/TrEMBL
    Q499L9
    Related
    ENSP00000377867.2, ENST00000394334.7
    Conserved Domains (1) summary
    cd06640
    Location:19 → 295
    STKc_MST4; Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    132023302..132075943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442155.1 → XP_047298111.1  serine/threonine-protein kinase 26 isoform X1

  2. XM_047442156.1 → XP_047298112.1  serine/threonine-protein kinase 26 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    130347539..130400176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327183.1 → XP_054183158.1  serine/threonine-protein kinase 26 isoform X1

  2. XM_054327184.1 → XP_054183159.1  serine/threonine-protein kinase 26 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P289.2 GenPept UniProtKB/Swiss-Prot:Q9P289

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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