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MAPK14 mitogen-activated protein kinase 14 [ Bos taurus (cattle) ]

Gene ID: 534492, updated on 3-Apr-2024

Summary

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Official Symbol
MAPK14provided by VGNC
Official Full Name
mitogen-activated protein kinase 14provided by VGNC
Primary source
VGNC:VGNC:31216
See related
BGD:BT11558; Ensembl:ENSBTAG00000020783
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
p38
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 23
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (9970264..10045594)

Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene SRSF protein kinase 1 Neighboring gene transcription factor E2F5-like Neighboring gene U6 spliceosomal RNA Neighboring gene solute carrier family 26 member 8 Neighboring gene mitogen-activated protein kinase 13 Neighboring gene bromodomain and PHD finger containing 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Intracellular Staphylococcus aureus inhibits autophagy of bovine mammary epithelial cells through activating p38α. Wang R, et al. J Dairy Res, 2021 Aug. PMID 34425921
  2. Hydrogen peroxide signaling mediator in the activation of p38 MAPK in vascular endothelial cells. Bretón-Romero R, et al. Methods Enzymol, 2013. PMID 23849858
  3. P38 mitogen-activated protein kinase promotes dedifferentiation of primary articular chondrocytes in monolayer culture. Rosenzweig DH, et al. J Cell Mol Med, 2013 Apr. PMID 23480786, Free PMC Article
  4. Bovine spermatozoa react to in vitro heat stress by activating the mitogen-activated protein kinase 14 signalling pathway. Rahman MB, et al. Reprod Fertil Dev, 2014 Jan. PMID 23327743
  5. Ischemia-induced stimulation of cerebral microvascular endothelial cell Na-K-Cl cotransport involves p38 and JNK MAP kinases. Wallace BK, et al. Am J Physiol Cell Physiol, 2012 Feb 1. PMID 22049209, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Intracellular Staphylococcus aureus inhibits autophagy of bovine mammary epithelial cells through activating p38alpha.
    Title: Intracellular Staphylococcus aureus inhibits autophagy of bovine mammary epithelial cells through activating p38α.
  2. Histamine triggers the formation of neutrophil extracellular traps via NADPH oxidase, ERK and p38 pathways.
    Title: Histamine triggers the formation of neutrophil extracellular traps via NADPH oxidase, ERK and p38 pathways.
  3. results suggest that ET-1-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase-PKCalpha-p(38)MAPK and NFkappaB-MT1MMP signaling pathways along with a marked decrease in TIMP-2 expression in the cells
    Title: Cross-talk between NADPH oxidase-PKCα-p(38)MAPK and NF-κB-MT1MMP in activating proMMP-2 by ET-1 in pulmonary artery smooth muscle cells.
  4. cross-talk between p(38)MAPK and Gialpha play a pivotal role for full activation of cPLA2 during ET-1 stimulation of pulmonary artery smooth muscle cells.
    Title: Cross-talk between p(38)MAPK and G iα in regulating cPLA 2 activity by ET-1 in pulmonary smooth muscle cells.
  5. MAPK14 signalling pathway is largely involved in heat-induced sperm damage.
    Title: Bovine spermatozoa react to in vitro heat stress by activating the mitogen-activated protein kinase 14 signalling pathway.
  6. p38 MAPK is an early redox sensor in the laminar shear stress with hydrogen peroxide being a signaling mediator.
    Title: Hydrogen peroxide signaling mediator in the activation of p38 MAPK in vascular endothelial cells.
  7. Blockade of p38 enhances chondrocyte phenotype in monolayer culture and may promote more efficient cartilage tissue regeneration for cell-based therapies.
    Title: P38 mitogen-activated protein kinase promotes dedifferentiation of primary articular chondrocytes in monolayer culture.
  8. p38 phosphorylation and MMP13 expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
    Title: Cyclic compression-induced p38 activation and subsequent MMP13 expression requires Rho/ROCK activity in bovine cartilage explants.
  9. These data suggest that the p38 and JNK signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.
    Title: Stress-activated protein kinases are involved in porcine reproductive and respiratory syndrome virus infection and modulate virus-induced cytokine production.
  10. findings support the hypothesis that ischemic factor stimulation of the blood-brain barrier Na-K-Cl cotransporter involves activation of p38 and JNK MAPKs
    Title: Ischemia-induced stimulation of cerebral microvascular endothelial cell Na-K-Cl cotransport involves p38 and JNK MAP kinases.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC142910

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase 14
NP_001095644.1
XP_010816425.1
XP_010816426.1
XP_015315258.1
XP_059736373.1
XP_059736374.1
XP_059736375.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102174.1 → NP_001095644.1  mitogen-activated protein kinase 14

    See identical proteins and their annotated locations for NP_001095644.1

    Status: PROVISIONAL

    Source sequence(s)
    BC148063
    UniProtKB/TrEMBL
    A6QLR9, F6PU21
    Related
    ENSBTAP00000023988.7, ENSBTAT00000023988.7
    Conserved Domains (1) summary
    cd07877
    Location:6 → 350
    STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    9970264..10045594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010818123.3 → XP_010816425.1  mitogen-activated protein kinase 14 isoform X1

    See identical proteins and their annotated locations for XP_010816425.1

    UniProtKB/TrEMBL
    F6PU21
    Related
    ENSBTAP00000058569.2, ENSBTAT00000073013.2
    Conserved Domains (1) summary
    cd07877
    Location:6 → 350
    STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)

  2. XM_059880390.1 → XP_059736373.1  mitogen-activated protein kinase 14 isoform X3

    Related
    ENSBTAP00000064936.2, ENSBTAT00000073555.2

  3. XM_059880392.1 → XP_059736375.1  mitogen-activated protein kinase 14 isoform X6

    Related
    ENSBTAP00000093074.1, ENSBTAT00000091409.1

  4. XM_015459772.3 → XP_015315258.1  mitogen-activated protein kinase 14 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:24 → 253
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:6 → 254
    PKc_like; Protein Kinases, catalytic domain

  5. XM_059880391.1 → XP_059736374.1  mitogen-activated protein kinase 14 isoform X5

  6. XM_010818124.4 → XP_010816426.1  mitogen-activated protein kinase 14 isoform X4

    UniProtKB/TrEMBL
    F6PU21
    Conserved Domains (1) summary
    cl21453
    Location:6 → 316
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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