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PNLIPRP2 pancreatic lipase related protein 2 (gene/pseudogene) [ Homo sapiens (human) ]

Gene ID: 5408, updated on 4-Jan-2025

Summary

Official Symbol
PNLIPRP2provided by HGNC
Official Full Name
pancreatic lipase related protein 2 (gene/pseudogene)provided by HGNC
Primary source
HGNC:HGNC:9157
See related
Ensembl:ENSG00000266200 MIM:604423; AllianceGenome:HGNC:9157
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLRP2
Summary
This gene encodes a lipase that hydrolyzes galactolipids, the main components of plant membrane lipids. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the non-coding allele. [provided by RefSeq, Aug 2015]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Restricted expression toward pancreas (RPKM 1148.7) See more
Orthologs
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Genomic context

See PNLIPRP2 in Genome Data Viewer
Location:
10q25.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (116620953..116645143)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (117515050..117539456)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (118380465..118404654)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr10:118347975-118348179 Neighboring gene pancreatic lipase pseudogene 1 Neighboring gene uncharacterized LOC124902510 Neighboring gene pancreatic lipase related protein 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:118393650-118394849 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118405699-118406228 Neighboring gene HSPA12A antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 10762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118441833-118442334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118442335-118442834 Neighboring gene sperm microtubule inner protein 5 Neighboring gene heat shock protein family A (Hsp70) member 12A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118450610-118451348 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118453631-118454602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118501942-118502646 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118502647-118503350 Neighboring gene ribosomal protein L5 pseudogene 27

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding PubMed 
enables galactolipase activity  
enables galactolipase activity PubMed 
enables lipoprotein lipase activity  
enables monoacylglycerol lipase activity PubMed 
enables monoacylglycerol lipase activity  
enables phospholipase A1 activity  
enables phospholipase activity PubMed 
enables protein binding PubMed 
enables triacylglycerol lipase activity PubMed 
enables triacylglycerol lipase activity  
Component Evidence Code Pubs
located_in extracellular region  
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in neuron projection  
located_in zymogen granule membrane  

General protein information

Preferred Names
pancreatic lipase-related protein 2
Names
cytotoxic T lymphocyte lipase
galactolipase
triacylglycerol lipase
NP_005387.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005396.5NP_005387.3  pancreatic lipase-related protein 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) differs at a polymorphic nucleotide compared to the reference genome sequence and represents the protein coding allele.
    Source sequence(s)
    BC005989, BP325072, BQ786898, BU078199
    UniProtKB/Swiss-Prot
    A0A075B781, A8K627, P54317, Q6IB55
    UniProtKB/TrEMBL
    A0AAG2UV77
    Conserved Domains (2) summary
    cd01759
    Location:357469
    PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
    pfam00151
    Location:18354
    Lipase

RNA

  1. NR_103727.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) contains a polymorphic nt that creates an early termination codon compared to variant 1, coding. The resulting transcript is considered to be non-protein coding since it is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA367174, AK291492, BQ786898, M93284
    Related
    ENST00000579578.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    116620953..116645143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791790.1 Reference GRCh38.p14 PATCHES

    Range
    31949..56139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    117515050..117539456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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