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mybpc2b myosin binding protein Cb [ Danio rerio (zebrafish) ]

Gene ID: 541384, updated on 27-Mar-2024

Summary

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Official Symbol
mybpc2bprovided by ZNC
Official Full Name
myosin binding protein Cbprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050320-80
See related
Ensembl:ENSDARG00000021265 AllianceGenome:ZFIN:ZDB-GENE-050320-80
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7137115; im:7150089; zgc:110761
Summary
Acts upstream of or within muscle tissue development. Is expressed in several structures, including adaxial cell; musculature system; otic placode; otic vesicle; and trunk. Used to study myopathy. Orthologous to human MYBPC2 (myosin binding protein C2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 24
Exon count:
30
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (38259520..38348808)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (38371559..38460935)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene zgc:91999 Neighboring gene leucine rich repeat containing 4Bb Neighboring gene uncharacterized LOC108179067

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model. Da'as SI, et al. Int J Mol Sci, 2022 Aug 9. PMID 36012114, Free PMC Article
  2. Knockdown of fast skeletal myosin-binding protein C in zebrafish results in a severe skeletal myopathy. Li M, et al. J Gen Physiol, 2016 Apr. PMID 27022191, Free PMC Article
  3. Copper ions impair zebrafish skeletal myofibrillogenesis via epigenetic regulation. Jin X, et al. FASEB J, 2021 Jul. PMID 34101239
  4. Hypoxia-induced changes in the zebrafish (Danio rerio) skeletal muscle proteome. Chen K, et al. J Proteomics, 2013 Jan 14. PMID 23117182
  5. The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Hawkins TA, et al. Development, 2008 Mar. PMID 18256191, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. lack of MyBPC-2 results in a severe skeletal myopathy, elevated apoptosis and shorter sarcomeres.
    Title: Knockdown of fast skeletal myosin-binding protein C in zebrafish results in a severe skeletal myopathy.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in M band IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myosin binding protein Cb; myosin-binding protein C, fast-type
Names
myosin binding protein C, fast type b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013511.2 → NP_001013529.2  myosin binding protein Cb

    Status: PROVISIONAL

    Source sequence(s)
    BC091662, CK677061, CK677308, EB776017, EB790963, EB866488, EE327610, EE714531, EE714901, EE719585
    UniProtKB/TrEMBL
    A0A8M1N4T5, Q5BJ14
    Conserved Domains (7) summary
    cd00096
    Location:1032 → 1097
    Ig; Immunoglobulin domain
    cd05748
    Location:822 → 894
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd05894
    Location:515 → 600
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:518 → 600
    IG_like; Immunoglobulin like
    cd00063
    Location:604 → 690
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1013 → 1102
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:224 → 295
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    38259520..38348808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017353828.2 → XP_017209317.1  myosin-binding protein C, fast-type isoform X2

    UniProtKB/TrEMBL
    A0A8M6YW81, Q5BJ14

  2. XM_021470160.1 → XP_021325835.1  myosin-binding protein C, fast-type isoform X3

    UniProtKB/TrEMBL
    A0A8M9PXG3, Q5BJ14
    Related
    ENSDARP00000096449.5, ENSDART00000105672.5
    Conserved Domains (6) summary
    cd05894
    Location:508 → 593
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:26 → 121
    IG_like; Immunoglobulin like
    cd00063
    Location:597 → 683
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1006 → 1095
    I-set; Immunoglobulin I-set domain
    cd05748
    Location:815 → 887
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar domains
    cl28434
    Location:397 → 468
    I-set; Immunoglobulin I-set domain

  3. XM_021470159.1 → XP_021325834.1  myosin-binding protein C, fast-type isoform X1

    UniProtKB/TrEMBL
    A0A8M9PLR4, Q5BJ14
    Conserved Domains (6) summary
    cd05894
    Location:514 → 599
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:32 → 127
    IG_like; Immunoglobulin like
    cd00063
    Location:603 → 689
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1012 → 1101
    I-set; Immunoglobulin I-set domain
    cd05748
    Location:821 → 893
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar domains
    cl28434
    Location:403 → 474
    I-set; Immunoglobulin I-set domain

  4. XM_021470161.1 → XP_021325836.1  myosin-binding protein C, fast-type isoform X4

    UniProtKB/TrEMBL
    A0A8M9PU17, Q5BJ14
    Conserved Domains (6) summary
    cd05894
    Location:508 → 593
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:26 → 121
    IG_like; Immunoglobulin like
    cd00063
    Location:597 → 683
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1006 → 1095
    I-set; Immunoglobulin I-set domain
    cd05748
    Location:815 → 887
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar domains
    cl28434
    Location:397 → 468
    I-set; Immunoglobulin I-set domain

  5. XM_021470162.1 → XP_021325837.1  myosin-binding protein C, fast-type isoform X5

    UniProtKB/TrEMBL
    A0A8M9P5V8, Q5BJ14
    Related
    ENSDARP00000115895.1, ENSDART00000143184.2
    Conserved Domains (6) summary
    cd05894
    Location:507 → 592
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:25 → 120
    IG_like; Immunoglobulin like
    cd00063
    Location:596 → 682
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1005 → 1094
    I-set; Immunoglobulin I-set domain
    cd05748
    Location:814 → 886
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar domains
    cl28434
    Location:396 → 467
    I-set; Immunoglobulin I-set domain
Nucleotide Protein Strain
Heading Accession and Version

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