casp8ap2 caspase 8 associated protein 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: casp8ap2provided by ZNC
Official Full Name: caspase 8 associated protein 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030826-8
See related: Ensembl:ENSDARG00000022718 AllianceGenome:ZFIN:ZDB-GENE-030826-8
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: FLASH; fc74h10; wu:fc74h10; zgc:113449
Summary: Predicted to enable transcription corepressor activity. Predicted to be involved in Fas signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; and extrinsic apoptotic signaling pathway via death domain receptors. Predicted to act upstream of or within apoptotic signaling pathway. Predicted to be active in PML body and mitochondrion. Orthologous to human CASP8AP2 (caspase 8 associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (23946992..23956014)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (24047892..24056914)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Fas signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in PML body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CASP8-associated protein 2

Names: CASP8 associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014334.2 → NP_001014356.2 CASP8-associated protein 2

Status: VALIDATED

Source sequence(s)

BX510339

UniProtKB/TrEMBL

A0A8M1N4R8, F1QB51, F1QD18

Related

ENSDARP00000120799.2, ENSDART00000144195.4

Conserved Domains (1) summary

cd12202
Location:1927 → 1991

CASP8AP2; Caspase 8-associated protein 2 myb-like domain