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GPR85 G protein-coupled receptor 85 [ Homo sapiens (human) ]

Gene ID: 54329, updated on 3-Apr-2024

Summary

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Official Symbol
GPR85provided by HGNC
Official Full Name
G protein-coupled receptor 85provided by HGNC
Primary source
HGNC:HGNC:4536
See related
Ensembl:ENSG00000164604 MIM:605188; AllianceGenome:HGNC:4536
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SREB; SREB2
Summary
Members of the G protein-coupled receptor (GPCR) family, such as GPR85, have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli, such as neurotransmitters, hormones, or light, induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins (Matsumoto et al., 2000 [PubMed 10833454]).[supplied by OMIM, Aug 2008]
Expression
Biased expression in brain (RPKM 3.3), testis (RPKM 1.1) and 12 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
7q31.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (113082285..113087724, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (114401309..114406733, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (112722340..112727779, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26517 Neighboring gene base methyltransferase of 25S rRNA 2 homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26519 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:112556531-112557032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:112557033-112557532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18545 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:112579888-112580404 Neighboring gene heart tissue-associated transcript 17 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18546 Neighboring gene uncharacterized LOC107986837 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:112758380-112758974 Neighboring gene small integral membrane protein 30 Neighboring gene NANOG hESC enhancer GRCh37_chr7:112828377-112828990 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:112902892-112903479 Neighboring gene NANOG hESC enhancer GRCh37_chr7:113061672-113062194 Neighboring gene uncharacterized LOC124901813

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Effect of schizophrenia risk-associated alleles in SREB2 (GPR85) on functional MRI phenotypes in healthy volunteers. Radulescu E, et al. Neuropsychopharmacology, 2013 Jan. PMID 22968816, Free PMC Article
  2. Cloning and localization of rgpr85 encoding rat G-protein-coupled receptor. Jeon J, et al. Biochem Biophys Res Commun, 2002 Nov 8. PMID 12408996
  3. The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia. Matsumoto M, et al. Proc Natl Acad Sci U S A, 2008 Apr 22. PMID 18413613, Free PMC Article
  4. A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. Matsumoto M, et al. Brain Res Mol Brain Res, 2005 Jul 29. PMID 15893849
  5. The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31. Hellebrand S, et al. Biochim Biophys Acta, 2000 Sep 7. PMID 10978537

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Risk-associated variants in GPR85 are associated with phenotypes similar to those found in patients with schizophrenia.
    Title: Effect of schizophrenia risk-associated alleles in SREB2 (GPR85) on functional MRI phenotypes in healthy volunteers.
  2. Theses data implicate SREB2 as a potential risk factor for psychiatric disorders.
    Title: The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia.
  3. The areas expressing high levels of SREB2 mRNA overlap with brain structures known to possess high levels of plasticity, namely, the hippocampal formation, olfactory system, and supraoptic and paraventricular nuclei.
    Title: A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of G protein-coupled receptor 85 (GPR85) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ50993, FLJ51159, FLJ99433

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 85
Names
seven transmembrane helix receptor
super conserved receptor expressed in brain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146265.2 → NP_001139737.1  probable G-protein coupled receptor 85

    See identical proteins and their annotated locations for NP_001139737.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants (1-4) encode the same protein.
    Source sequence(s)
    AC073346
    Consensus CDS
    CCDS5758.1
    UniProtKB/Swiss-Prot
    P60893, Q9JHI6, Q9NPD1
    UniProtKB/TrEMBL
    A4D0T8, Q8NEN2
    Related
    ENSP00000297146.2, ENST00000297146.7
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001146266.2 → NP_001139738.1  probable G-protein coupled receptor 85

    See identical proteins and their annotated locations for NP_001139738.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
    Source sequence(s)
    AC073346
    Consensus CDS
    CCDS5758.1
    UniProtKB/Swiss-Prot
    P60893, Q9JHI6, Q9NPD1
    UniProtKB/TrEMBL
    A4D0T8, Q8NEN2
    Related
    ENSP00000401178.1, ENST00000449591.2
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001146267.2 → NP_001139739.1  probable G-protein coupled receptor 85

    See identical proteins and their annotated locations for NP_001139739.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
    Source sequence(s)
    AC073346
    Consensus CDS
    CCDS5758.1
    UniProtKB/Swiss-Prot
    P60893, Q9JHI6, Q9NPD1
    UniProtKB/TrEMBL
    A4D0T8, Q8NEN2
    Related
    ENSP00000396763.1, ENST00000424100.2
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_018970.7 → NP_061843.3  probable G-protein coupled receptor 85

    See identical proteins and their annotated locations for NP_061843.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
    Source sequence(s)
    AC073346
    Consensus CDS
    CCDS5758.1
    UniProtKB/Swiss-Prot
    P60893, Q9JHI6, Q9NPD1
    UniProtKB/TrEMBL
    A4D0T8, Q8NEN2
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    113082285..113087724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250451.3 → XP_005250508.1  probable G-protein coupled receptor 85 isoform X1

    See identical proteins and their annotated locations for XP_005250508.1

    UniProtKB/Swiss-Prot
    P60893, Q9JHI6, Q9NPD1
    UniProtKB/TrEMBL
    A4D0T8, Q8NEN2
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_017012352.3 → XP_016867841.1  probable G-protein coupled receptor 85 isoform X1

    UniProtKB/Swiss-Prot
    P60893, Q9JHI6, Q9NPD1
    UniProtKB/TrEMBL
    A4D0T8, Q8NEN2
    Conserved Domains (1) summary
    cd15218
    Location:21 → 350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    114401309..114406733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358466.1 → XP_054214441.1  probable G-protein coupled receptor 85 isoform X1

    UniProtKB/Swiss-Prot
    P60893, Q9JHI6, Q9NPD1
    UniProtKB/TrEMBL
    A4D0T8

  2. XM_054358465.1 → XP_054214440.1  probable G-protein coupled receptor 85 isoform X1

    UniProtKB/Swiss-Prot
    P60893, Q9JHI6, Q9NPD1
    UniProtKB/TrEMBL
    A4D0T8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60893.1 GenPept UniProtKB/Swiss-Prot:P60893

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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