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Nme6 NME/NM23 nucleoside diphosphate kinase 6 [ Mus musculus (house mouse) ]

Gene ID: 54369, updated on 12-May-2024

Summary

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Official Symbol
Nme6provided by MGI
Official Full Name
NME/NM23 nucleoside diphosphate kinase 6provided by MGI
Primary source
MGI:MGI:1861676
See related
Ensembl:ENSMUSG00000032478 AllianceGenome:MGI:1861676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
nm23-M6
Summary
Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in negative regulation of cell growth and negative regulation of mitotic nuclear division. Predicted to act upstream of or within nucleotide metabolic process and phosphorylation. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Orthologous to human NME6 (NME/NM23 nucleoside diphosphate kinase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 39.4), placenta adult (RPKM 12.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Nme6 in Genome Data Viewer
Location:
9 F2; 9 59.79 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (109661830..109672042)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (109832722..109842974)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51691 Neighboring gene serine peptidase inhibitor, Kazal type 8 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene cathelicidin antimicrobial peptide Neighboring gene STARR-positive B cell enhancer ABC_E9775 Neighboring gene predicted gene, 39427

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A shRNA functional screen reveals Nme6 and Nme7 are crucial for embryonic stem cell renewal. Wang CH, et al. Stem Cells, 2012 Oct. PMID 22899353
  2. NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3. Mehus JG, et al. Hum Genet, 1999 Jun. PMID 10453732
  3. DDX1 vesicles control calcium-dependent mitochondrial activity in mouse embryos. Wang Y, et al. Nat Commun, 2022 Jul 1. PMID 35778392, Free PMC Article
  4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nme6 or Nme7 can regulate several critical processes in embryonic stem cell renewal.
    Title: A shRNA functional screen reveals Nme6 and Nme7 are crucial for embryonic stem cell renewal.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleoside diphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in UTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell growth IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nucleoside diphosphate kinase 6
Names
NDK 6
NDP kinase 6
expressed in non-metastatic cells 6, protein (nucleoside diphosphate kinase)
nm23/nucleoside diphosphate kinase 6
non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)
nucleoside diphosphate kinase type 6
NP_001396623.1
NP_001396624.1
NP_001396625.1
NP_001396627.1
NP_001396628.1
NP_001396629.1
NP_001396630.1
NP_001396631.1
NP_001396632.1
NP_061227.1
XP_006512262.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409694.1 → NP_001396623.1  nucleoside diphosphate kinase 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163619
    UniProtKB/Swiss-Prot
    O88425, Q99M53

  2. NM_001409695.1 → NP_001396624.1  nucleoside diphosphate kinase 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163619
    UniProtKB/Swiss-Prot
    O88425, Q99M53
    Related
    ENSMUSP00000142609.2, ENSMUST00000200005.5

  3. NM_001409696.1 → NP_001396625.1  nucleoside diphosphate kinase 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163619
    UniProtKB/Swiss-Prot
    O88425, Q99M53

  4. NM_001409698.1 → NP_001396627.1  nucleoside diphosphate kinase 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163619
    UniProtKB/Swiss-Prot
    O88425, Q99M53
    Related
    ENSMUSP00000143021.2, ENSMUST00000200468.2

  5. NM_001409699.1 → NP_001396628.1  nucleoside diphosphate kinase 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163619

  6. NM_001409700.1 → NP_001396629.1  nucleoside diphosphate kinase 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163619
    Related
    ENSMUST00000196797.5

  7. NM_001409701.1 → NP_001396630.1  nucleoside diphosphate kinase 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163619
    Related
    ENSMUST00000198201.5

  8. NM_001409702.1 → NP_001396631.1  nucleoside diphosphate kinase 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163619

  9. NM_001409703.1 → NP_001396632.1  nucleoside diphosphate kinase 6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC163619
    UniProtKB/TrEMBL
    A0A0G2JEH8
    Related
    ENSMUSP00000142778.2, ENSMUST00000197627.5

  10. NM_018757.2 → NP_061227.1  nucleoside diphosphate kinase 6 isoform 1

    See identical proteins and their annotated locations for NP_061227.1

    Status: VALIDATED

    Source sequence(s)
    AC163619
    Consensus CDS
    CCDS23558.1
    UniProtKB/Swiss-Prot
    O88425, Q99M53
    UniProtKB/TrEMBL
    A0A0G2JE30
    Related
    ENSMUSP00000035053.6, ENSMUST00000035053.12
    Conserved Domains (1) summary
    cd04414
    Location:12 → 146
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...

RNA

  1. NR_176891.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163619

  2. NR_176892.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163619

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    109661830..109672042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512199.4 → XP_006512262.1  nucleoside diphosphate kinase 6 isoform X1

    See identical proteins and their annotated locations for XP_006512262.1

    UniProtKB/Swiss-Prot
    O88425, Q99M53
    UniProtKB/TrEMBL
    A0A0G2JE30
    Conserved Domains (1) summary
    cd04414
    Location:12 → 146
    NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88425.1 GenPept UniProtKB/Swiss-Prot:O88425

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