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MED1 mediator complex subunit 1 [ Homo sapiens (human) ]

Gene ID: 5469, updated on 4-Jan-2025

Summary

Official Symbol
MED1provided by HGNC
Official Full Name
mediator complex subunit 1provided by HGNC
Primary source
HGNC:HGNC:9234
See related
Ensembl:ENSG00000125686 MIM:604311; AllianceGenome:HGNC:9234
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PBP; CRSP1; RB18A; TRIP2; PPARBP; CRSP200; DRIP205; DRIP230; PPARGBP; TRAP220
Summary
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 8.1), appendix (RPKM 7.7) and 25 other tissues See more
Orthologs
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Genomic context

See MED1 in Genome Data Viewer
Location:
17q12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (39404285..39451263, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (40268198..40315170, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37560538..37607516, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene transcription factor CP2-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37400607-37401181 Neighboring gene F-box and leucine rich repeat protein 20 Neighboring gene microRNA 548BC Neighboring gene MPRA-validated peak2834 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:37489325-37489835 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:37493495-37494252 Neighboring gene Sharpr-MPRA regulatory region 12086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8453 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8454 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:37557132-37557424 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8455 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8456 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:37558864-37559028 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:37618166-37619365 Neighboring gene U6 spliceosomal RNA Neighboring gene cyclin dependent kinase 12 Neighboring gene RNA, U6 small nuclear 233, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 MA upregulates MED1 mRNA expression in HepG2 cells PubMed
gag HIV-1 MA upregulates MED1 gene expression in HepG2 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC71488

Gene Ontology Provided by GOA

Items 1 - 25 of 32
Function Evidence Code Pubs
enables DNA-binding transcription factor binding PubMed 
enables LBD domain binding PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables chromatin DNA binding  
enables chromatin binding PubMed 
enables general transcription initiation factor binding  
enables histone acetyltransferase binding  
enables nuclear estrogen receptor binding PubMed 
enables nuclear receptor binding PubMed 
enables nuclear receptor binding PubMed 
enables nuclear receptor coactivator activity PubMed 
enables nuclear receptor coactivator activity PubMed 
enables nuclear retinoic acid receptor binding  
enables nuclear retinoic acid receptor binding PubMed 
enables nuclear thyroid hormone receptor binding  
enables nuclear thyroid hormone receptor binding PubMed 
enables nuclear thyroid hormone receptor binding PubMed 
enables nuclear vitamin D receptor binding  
enables nuclear vitamin D receptor binding PubMed 
enables nuclear vitamin D receptor binding PubMed 
enables nuclear vitamin D receptor binding PubMed 
enables peroxisome proliferator activated receptor binding PubMed 
enables promoter-specific chromatin binding  
enables protein binding PubMed 
enables protein-containing complex binding  
enables transcription coactivator activity PubMed 
enables transcription coactivator activity PubMed 
enables transcription coactivator binding PubMed 
enables transcription coregulator activity  
enables transcription coregulator activity PubMed 
enables transcription corepressor activity  
enables ubiquitin protein ligase activity  
Items 1 - 25 of 32
Items 1 - 25 of 60
Process Evidence Code Pubs
involved_in G0 to G1 transition  
involved_in RNA polymerase II preinitiation complex assembly PubMed 
involved_in androgen biosynthetic process PubMed 
involved_in angiogenesis  
involved_in animal organ regeneration  
involved_in brain development  
involved_in cell morphogenesis PubMed 
involved_in cellular response to epidermal growth factor stimulus PubMed 
involved_in cellular response to hepatocyte growth factor stimulus  
involved_in cellular response to steroid hormone stimulus PubMed 
involved_in cellular response to thyroid hormone stimulus  
involved_in cellular response to thyroid hormone stimulus PubMed 
involved_in embryonic heart tube development  
involved_in embryonic hemopoiesis  
involved_in embryonic hindlimb morphogenesis  
involved_in embryonic placenta development  
involved_in enucleate erythrocyte development  
involved_in epithelial cell proliferation involved in mammary gland duct elongation  
involved_in erythrocyte development  
acts_upstream_of_or_within fat cell differentiation PubMed 
involved_in hematopoietic stem cell differentiation  
involved_in keratinocyte differentiation PubMed 
involved_in lactation  
involved_in lens development in camera-type eye  
involved_in liver development  
involved_in mRNA transcription by RNA polymerase II  
involved_in mammary gland branching involved in pregnancy  
involved_in mammary gland branching involved in thelarche  
involved_in megakaryocyte development  
involved_in monocyte differentiation  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of keratinocyte proliferation PubMed 
involved_in negative regulation of neuron differentiation  
involved_in negative regulation of transcription by RNA polymerase II  
involved_in nuclear receptor-mediated steroid hormone signaling pathway PubMed 
involved_in peroxisome proliferator activated receptor signaling pathway  
involved_in positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of G0 to G1 transition  
involved_in positive regulation of erythrocyte differentiation PubMed 
involved_in positive regulation of gene expression PubMed 
involved_in positive regulation of gene expression PubMed 
involved_in positive regulation of hepatocyte proliferation  
involved_in positive regulation of intracellular estrogen receptor signaling pathway  
involved_in positive regulation of keratinocyte differentiation PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II PubMed 
involved_in positive regulation of type II interferon-mediated signaling pathway  
involved_in protein import into nucleus  
involved_in protein ubiquitination  
involved_in regulation of RNA biosynthetic process PubMed 
involved_in regulation of transcription by RNA polymerase II  
involved_in regulation of vitamin D receptor signaling pathway  
involved_in retinal pigment epithelium development  
involved_in thyroid hormone generation  
involved_in thyroid hormone receptor signaling pathway PubMed 
involved_in ventricular trabecula myocardium morphogenesis  
Items 1 - 25 of 60
Component Evidence Code Pubs
located_in chromatin  
part_of core mediator complex PubMed 
part_of mediator complex  
part_of mediator complex PubMed 
part_of mediator complex PubMed 
located_in membrane PubMed 
located_in nucleolus PubMed 
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus PubMed 
part_of protein-DNA complex  
part_of ubiquitin ligase complex  

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 1
Names
ARC205
PPAR-binding protein
PPARG binding protein
TR-interacting protein 2
TRIP-2
activator-recruited cofactor 205 kDa component
p53 regulatory protein RB18A
peroxisome proliferator-activated receptor-binding protein
thyroid hormone receptor-associated protein complex 220 kDa component
thyroid hormone receptor-associated protein complex component TRAP220
thyroid receptor interacting protein 2
vitamin D receptor-interacting protein 230 kD
vitamin D receptor-interacting protein complex component DRIP205

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046996.1 RefSeqGene

    Range
    5018..51996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004774.4NP_004765.2  mediator of RNA polymerase II transcription subunit 1

    See identical proteins and their annotated locations for NP_004765.2

    Status: REVIEWED

    Source sequence(s)
    AC005288, BC131783, BP357374
    Consensus CDS
    CCDS11336.1
    UniProtKB/Swiss-Prot
    A2RRQ6, O43810, O75447, Q15648, Q6P9H7, Q6PK58, Q9HD39
    UniProtKB/TrEMBL
    B2RAG9
    Related
    ENSP00000300651.6, ENST00000300651.11
    Conserved Domains (2) summary
    PTZ00449
    Location:9421079
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam10744
    Location:60426
    Med1; Mediator of RNA polymerase II transcription subunit 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    39404285..39451263 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721957.3XP_006722020.1  mediator of RNA polymerase II transcription subunit 1 isoform X3

    Related
    ENSP00000377828.3, ENST00000394287.7
    Conserved Domains (1) summary
    pfam10744
    Location:60426
    Med1; Mediator of RNA polymerase II transcription subunit 1
  2. XM_047436314.1XP_047292270.1  mediator of RNA polymerase II transcription subunit 1 isoform X1

    UniProtKB/TrEMBL
    B4DSK7
  3. XM_047436315.1XP_047292271.1  mediator of RNA polymerase II transcription subunit 1 isoform X2

    UniProtKB/TrEMBL
    B4DSK7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    40268198..40315170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316540.1XP_054172515.1  mediator of RNA polymerase II transcription subunit 1 isoform X3

  2. XM_054316538.1XP_054172513.1  mediator of RNA polymerase II transcription subunit 1 isoform X1

    UniProtKB/TrEMBL
    B4DSK7
  3. XM_054316539.1XP_054172514.1  mediator of RNA polymerase II transcription subunit 1 isoform X2

    UniProtKB/TrEMBL
    B4DSK7
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