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RBFOX1 RNA binding fox-1 homolog 1 [ Homo sapiens (human) ]

Gene ID: 54715, updated on 11-Apr-2024

Summary

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Official Symbol
RBFOX1provided by HGNC
Official Full Name
RNA binding fox-1 homolog 1provided by HGNC
Primary source
HGNC:HGNC:18222
See related
Ensembl:ENSG00000078328 MIM:605104; AllianceGenome:HGNC:18222
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
2BP1; FOX1; A2BP1; FOX-1; HRNBP1
Summary
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
Expression
Biased expression in brain (RPKM 11.3) and heart (RPKM 2.5) See more
Orthologs
mouse all
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Genomic context

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Location:
16p13.3
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (5239721..7713340)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (5269380..7744948)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (6069025..7763342)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371067 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr16:5262989-5263709 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:5286836-5288035 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:5298918-5299751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:5300840-5301508 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:5302176-5302843 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:5302844-5303510 Neighboring gene 40S ribosomal protein S24-like Neighboring gene long intergenic non-protein coding RNA 2164 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:5371684-5372883 Neighboring gene VPS51 pseudogene 1 Neighboring gene RPS3A pseudogene 48 Neighboring gene small nuclear ribonucleoprotein polypeptide C pseudogene 20 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:5496759-5497327 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:5500131-5500853 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:5500854-5501575 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:5609581-5610780 Neighboring gene nucleophosmin 1 pseudogene 3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:5692155-5693354 Neighboring gene MPRA-validated peak2482 silencer Neighboring gene MPRA-validated peak2483 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:5755936-5757135 Neighboring gene long intergenic non-protein coding RNA 1570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:5800209-5800710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:5800711-5801210 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:5804472-5805458 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:5845663-5846190 Neighboring gene microRNA 8065 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr16:5920971-5921940 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:5975719-5976364 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:6052649-6053848 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:6072816-6074015 Neighboring gene meiotic recombination hotspot CG Neighboring gene NANOG hESC enhancer GRCh37_chr16:6174118-6174635 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6226269-6227053 Neighboring gene NANOG hESC enhancer GRCh37_chr16:6348193-6348738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6372883-6373383 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6372382-6372882 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6391810-6392696 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6392697-6393582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6532635-6533560 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancers GRCh37_chr16:6607366-6608270 and GRCh37_chr16:6608271-6609174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6623253-6623754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6623755-6624254 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6910998-6911814 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6913069-6913652 Neighboring gene RNA, U7 small nuclear 99 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6963086-6963586 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:6975920-6976594 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:6976595-6977269 Neighboring gene RNA, U6 small nuclear 457, pseudogene Neighboring gene MPRA-validated peak2485 silencer Neighboring gene uncharacterized LOC105371068 Neighboring gene RNA, U6 small nuclear 328, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:7231546-7232745 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:7234679-7235878 Neighboring gene Sharpr-MPRA regulatory region 8564 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_44361 Neighboring gene MPRA-validated peak2487 silencer Neighboring gene ribosomal protein S26 pseudogene 51 Neighboring gene uncharacterized LOC124903640 Neighboring gene NANOG hESC enhancer GRCh37_chr16:7481632-7482288 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:7629446-7630645 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:7701751-7702302 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:7703336-7703942 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:7758954-7760153 Neighboring gene uncharacterized LOC124900381 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:7814521-7815243 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:7815244-7815965 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:7819497-7820696 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:7917473-7918672 Neighboring gene uncharacterized LOC105371069

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Behavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits. O'Leary A, et al. Mol Psychiatry, 2022 Nov. PMID 35948661, Free PMC Article
  2. Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease. Raghavan NS, et al. JAMA Neurol, 2020 Oct 1. PMID 32568366, Free PMC Article
  3. Polymorphisms of rs4787050 and rs8045980 are associated with lung cancer risk in northeast Chinese female nonsmokers. Li X, et al. Biomark Med, 2019 Sep. PMID 31512508
  4. RNA-binding protein (RBFOX1) inherited polymorphism rs8051518 is not associated with splice factor mutations in myelodysplastic syndromes and myeloproliferative neoplasms. Faisal M, et al. Ann Hematol, 2019 May. PMID 30159600
  5. Structural study of the Fox-1 RRM protein hydration reveals a role for key water molecules in RRM-RNA recognition. Krepl M, et al. Nucleic Acids Res, 2017 Jul 27. PMID 28505313, Free PMC Article

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Patient Brain Organoids Identify a Link between the 16p11.2 Copy Number Variant and the RBFOX1 Gene.
    Title: Patient Brain Organoids Identify a Link between the 16p11.2 Copy Number Variant and the RBFOX1 Gene.
  2. Behavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits.
    Title: Behavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits.
  3. Low-grade oncocytic renal tumor (LOT): mutations in mTOR pathway genes and low expression of FOXI1.
    Title: Low-grade oncocytic renal tumor (LOT): mutations in mTOR pathway genes and low expression of FOXI1.
  4. Differential Clinical Features in Colombian Patients With Rolandic Epilepsy and Suggestion of Unlikely Association With GRIN2A, RBFOX1, or RBFOX3 Gene Variants.
    Title: Differential Clinical Features in Colombian Patients With Rolandic Epilepsy and Suggestion of Unlikely Association With GRIN2A, RBFOX1, or RBFOX3 Gene Variants.
  5. RNA-binding proteins in neurological development and disease.
    Title: RNA-binding proteins in neurological development and disease.
  6. Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease.
    Title: Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease.
  7. Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.
    Title: Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.
  8. From Rare Copy Number Variants to Biological Processes in ADHD.
    Title: From Rare Copy Number Variants to Biological Processes in ADHD.
  9. The SNPs rs4787050 and rs8045980 showed a significant association with susceptibility to lung cancer. Moreover, cooking oil fume exposure was found to increase the risk of lung cancer.
    Title: Polymorphisms of rs4787050 and rs8045980 are associated with lung cancer risk in northeast Chinese female nonsmokers.
  10. this study shows that RBFOX1 is a susceptibility gene for an outbreak of hydrolyzed wheat allergy in Japan
    Title: HLA-DQ and RBFOX1 as susceptibility genes for an outbreak of hydrolyzed wheat allergy.
Submit: New GeneRIF Correction See all GeneRIFs (56)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of sleep habits and insomnia.
EBI GWAS Catalog
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
EBI GWAS Catalog
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
EBI GWAS Catalog
Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.
EBI GWAS Catalog
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.
EBI GWAS Catalog
Genome-wide association and admixture analysis of glaucoma in the Women's Health Initiative.
EBI GWAS Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Genome-wide association study and meta-analysis of intraocular pressure.
EBI GWAS Catalog
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
EBI GWAS Catalog
Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.
EBI GWAS Catalog
Genome-wide association study of chronic periodontitis in a general German population.
EBI GWAS Catalog
Genome-Wide Association Study of Primary Dentition Pit-and-Fissure and Smooth Surface Caries.
EBI GWAS Catalog
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
EBI GWAS Catalog
Genome-wide meta-analysis for severe diabetic retinopathy.
EBI GWAS Catalog
Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 Loci.
EBI GWAS Catalog
Genomewide association study of movement-related adverse antipsychotic effects.
EBI GWAS Catalog
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
EBI GWAS Catalog
Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RNA binding protein fox-1 homolog 1
Names
RNA binding protein, fox-1 homolog 1
ataxin 2-binding protein 1
fox-1 homolog A
fox-1-like RNA-binding protein 1
hexaribonucleotide-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011881.2 RefSeqGene

    Range
    784273..2478589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142333.2 → NP_001135805.1  RNA binding protein fox-1 homolog 1 isoform 5

    See identical proteins and their annotated locations for NP_001135805.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus and other internal differences compared to isoform 1.
    Source sequence(s)
    AB208826, AC005774, AC009135, AF448859
    Consensus CDS
    CCDS55984.1
    UniProtKB/TrEMBL
    A0A087X2B1
    Related
    ENSP00000447753.1, ENST00000553186.5
    Conserved Domains (3) summary
    PRK03427
    Location:4 → 122
    PRK03427; cell division protein ZipA; Provisional
    pfam12414
    Location:226 → 315
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:117 → 192
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  2. NM_001142334.2 → NP_001135806.1  RNA binding protein fox-1 homolog 1 isoform 4

    See identical proteins and their annotated locations for NP_001135806.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks an in-frame section of the 3' coding region, compared to variant 1. This results in a shorter isoform (4) with an alternate N-terminus compared to isoform 1. Variants 4 and 6 both encode isoform 4.
    Source sequence(s)
    AC005774, AF107203, AK001027
    Consensus CDS
    CCDS55983.1
    UniProtKB/Swiss-Prot
    Q7Z7I7, Q8TAE3, Q8TAF2, Q8WYB2, Q9NS20, Q9NWB1
    UniProtKB/TrEMBL
    I3L1D4
    Related
    ENSP00000447717.1, ENST00000547338.5
    Conserved Domains (3) summary
    PRK03427
    Location:4 → 122
    PRK03427; cell division protein ZipA; Provisional
    pfam12414
    Location:253 → 342
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:117 → 192
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  3. NM_001308117.1 → NP_001295046.1  RNA binding protein fox-1 homolog 1 isoform 6

    See identical proteins and their annotated locations for NP_001295046.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the UTRs and has multiple differences in the coding region which results in the use of an alternate start codon and a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (6) has a longer N-terminus and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC005774, AC027683, AK293951
    Consensus CDS
    CCDS76818.1
    UniProtKB/TrEMBL
    B7Z1U7, I3L1D4
    Related
    ENSP00000391269.4, ENST00000422070.8
    Conserved Domains (3) summary
    PRK03427
    Location:33 → 165
    PRK03427; cell division protein ZipA; Provisional
    pfam12414
    Location:296 → 385
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:160 → 235
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  4. NM_001364800.2 → NP_001351729.1  RNA binding protein fox-1 homolog 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152
    Consensus CDS
    CCDS92101.1
    UniProtKB/TrEMBL
    A0A6Q8PH77, F8VRS4
    Related
    ENSP00000502616.1, ENST00000675459.1
    Conserved Domains (3) summary
    PRK03427
    Location:4 → 122
    PRK03427; cell division protein ZipA; Provisional
    pfam12414
    Location:253 → 339
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:117 → 192
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  5. NM_001411047.1 → NP_001397976.1  RNA binding protein fox-1 homolog 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152
    Consensus CDS
    CCDS92100.1
    UniProtKB/TrEMBL
    F8VZG9
    Related
    ENSP00000446842.1, ENST00000547372.5

  6. NM_001415887.1 → NP_001402816.1  RNA binding protein fox-1 homolog 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC005563, AC005774, AC007012, AC007217, AC012175, AC022206, AC023822, AC027683, AC074051, KF456152

  7. NM_001415888.1 → NP_001402817.1  RNA binding protein fox-1 homolog 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC005563, AC005774, AC007012, AC007217, AC012175, AC022206, AC023822, AC027683, AC074051, KF456152

  8. NM_001415889.1 → NP_001402818.1  RNA binding protein fox-1 homolog 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007012, AC007223, AC022206, AC027683, KF456152
    Related
    ENSP00000438768.2, ENST00000535565.6

  9. NM_001415890.1 → NP_001402819.1  RNA binding protein fox-1 homolog 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007222, AC027683, KF456152

  10. NM_001415891.1 → NP_001402820.1  RNA binding protein fox-1 homolog 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152

  11. NM_001415892.1 → NP_001402821.1  RNA binding protein fox-1 homolog 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007012, AC007223, AC022206, AC027683, KF456152

  12. NM_001415893.1 → NP_001402822.1  RNA binding protein fox-1 homolog 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007222, AC027683, KF456152
    Related
    ENST00000676253.1

  13. NM_001415894.1 → NP_001402823.1  RNA binding protein fox-1 homolog 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007012, AC007223, AC022206, AC027683, KF456152

  14. NM_001415895.1 → NP_001402824.1  RNA binding protein fox-1 homolog 1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152

  15. NM_001415896.1 → NP_001402825.1  RNA binding protein fox-1 homolog 1 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007222, AC027683, KF456152
    UniProtKB/TrEMBL
    X5DNY3
    Related
    ENSP00000484837.1, ENST00000620507.4

  16. NM_001415897.1 → NP_001402826.1  RNA binding protein fox-1 homolog 1 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152

  17. NM_001415898.1 → NP_001402827.1  RNA binding protein fox-1 homolog 1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007012, AC007223, AC022206, AC027683, KF456152
    Related
    ENSP00000448496.1, ENST00000552089.5

  18. NM_001415899.1 → NP_001402828.1  RNA binding protein fox-1 homolog 1 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007222, AC027683, KF456152

  19. NM_001415900.1 → NP_001402829.1  RNA binding protein fox-1 homolog 1 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007012, AC007223, AC022206, AC027683, KF456152

  20. NM_001415901.1 → NP_001402830.1  RNA binding protein fox-1 homolog 1 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007222, AC027683, KF456152
    Related
    ENSP00000501878.1, ENST00000675562.1

  21. NM_001415902.1 → NP_001402831.1  RNA binding protein fox-1 homolog 1 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC027683, KF456152
    Related
    ENSP00000458748.2, ENST00000570626.2

  22. NM_001415903.1 → NP_001402832.1  RNA binding protein fox-1 homolog 1 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007222, AC027683, KF456152

  23. NM_001415904.1 → NP_001402833.1  RNA binding protein fox-1 homolog 1 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007222, AC027683, KF456152
    UniProtKB/TrEMBL
    X5D7T5

  24. NM_001415905.1 → NP_001402834.1  RNA binding protein fox-1 homolog 1 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007222, AC027683, KF456152

  25. NM_001415906.1 → NP_001402835.1  RNA binding protein fox-1 homolog 1 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007222, AC027683, KF456152

  26. NM_001415907.1 → NP_001402836.1  RNA binding protein fox-1 homolog 1 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152

  27. NM_001415908.1 → NP_001402837.1  RNA binding protein fox-1 homolog 1 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152

  28. NM_001415909.1 → NP_001402838.1  RNA binding protein fox-1 homolog 1 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007012, AC007223, AC022206, AC027683, KF456152

  29. NM_001415910.1 → NP_001402839.1  RNA binding protein fox-1 homolog 1 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007012, AC007223, AC022206, AC027683, KF456152

  30. NM_001415911.1 → NP_001402840.1  RNA binding protein fox-1 homolog 1 isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC027683, KF456152
    UniProtKB/TrEMBL
    A0A804HJM2
    Related
    ENSP00000507562.1, ENST00000683326.1

  31. NM_001415912.1 → NP_001402841.1  RNA binding protein fox-1 homolog 1 isoform 34

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007012, AC007223, AC022206, AC027683, KF456152

  32. NM_001415913.1 → NP_001402842.1  RNA binding protein fox-1 homolog 1 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007222, AC027683, KF456152

  33. NM_001415914.1 → NP_001402843.1  RNA binding protein fox-1 homolog 1 isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007012, AC007217, AC009135, AC022206, AC027683, KF456152

  34. NM_001415915.1 → NP_001402844.1  RNA binding protein fox-1 homolog 1 isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007222, AC027683, KF456152
    UniProtKB/TrEMBL
    X5DP44

  35. NM_001415916.1 → NP_001402845.1  RNA binding protein fox-1 homolog 1 isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC007012, AC007223, AC022206, AC027683, KF456152

  36. NM_001415917.1 → NP_001402846.1  RNA binding protein fox-1 homolog 1 isoform 39

    Status: REVIEWED

    Source sequence(s)
    AC005774, AC027683, KF456152
    UniProtKB/TrEMBL
    A0A804HKG7
    Related
    ENSP00000507921.1, ENST00000682918.1

  37. NM_018723.4 → NP_061193.2  RNA binding protein fox-1 homolog 1 isoform 4

    See identical proteins and their annotated locations for NP_061193.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame section of the 3' coding region, compared to variant 1. This results in a shorter isoform (4) with an alternate N-terminus compared to isoform 1. Variants 4 and 6 both encode isoform 4.
    Source sequence(s)
    AB208826, AC005774, AC009135, AF107203
    Consensus CDS
    CCDS55983.1
    UniProtKB/Swiss-Prot
    Q7Z7I7, Q8TAE3, Q8TAF2, Q8WYB2, Q9NS20, Q9NWB1
    UniProtKB/TrEMBL
    I3L1D4
    Related
    ENSP00000450031.1, ENST00000550418.6
    Conserved Domains (3) summary
    PRK03427
    Location:4 → 122
    PRK03427; cell division protein ZipA; Provisional
    pfam12414
    Location:253 → 342
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:117 → 192
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  38. NM_145891.3 → NP_665898.1  RNA binding protein fox-1 homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_665898.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as gamma, encodes isoform (1).
    Source sequence(s)
    AC005774, AF229057
    Consensus CDS
    CCDS10531.1
    UniProtKB/TrEMBL
    B7ZLH9
    Related
    ENSP00000309117.5, ENST00000311745.9
    Conserved Domains (3) summary
    TIGR01661
    Location:25 → 208
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    pfam12414
    Location:273 → 363
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:137 → 212
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  39. NM_145892.3 → NP_665899.1  RNA binding protein fox-1 homolog 1 isoform 2

    See identical proteins and their annotated locations for NP_665899.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as alpha, lacks an in-frame segment of the 3' coding region, compared to variant 1. This results in a shorter isoform (2) that lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC005774, AF094849
    Consensus CDS
    CCDS45405.1
    UniProtKB/TrEMBL
    I3L1D4
    Related
    ENSP00000402745.2, ENST00000436368.6
    Conserved Domains (3) summary
    TIGR01661
    Location:25 → 208
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    pfam12414
    Location:273 → 363
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:137 → 212
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  40. NM_145893.3 → NP_665900.1  RNA binding protein fox-1 homolog 1 isoform 3

    See identical proteins and their annotated locations for NP_665900.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as beta, has an alternate exon in the 3' coding region, compared to variant 1. This results in a shorter isoform (3) with an alternate C-terminus, compared to isoform 1.
    Source sequence(s)
    AC005774, AF109106
    Consensus CDS
    CCDS10532.1
    UniProtKB/TrEMBL
    A0A6Q8PFM4
    Related
    ENSP00000347855.4, ENST00000355637.9
    Conserved Domains (3) summary
    TIGR01661
    Location:25 → 208
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    pfam12414
    Location:273 → 360
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:137 → 212
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    5239721..7713340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023318.3 → XP_016878807.1  RNA binding protein fox-1 homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A286YEU2
    Related
    ENSP00000493041.1, ENST00000641259.1

  2. XM_024450303.2 → XP_024306071.1  RNA binding protein fox-1 homolog 1 isoform X2

    UniProtKB/TrEMBL
    A0A286YEU2
    Conserved Domains (4) summary
    PHA03169
    Location:18 → 156
    PHA03169; hypothetical protein; Provisional
    cd12407
    Location:303 → 378
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:439 → 528
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cl27169
    Location:176 → 308
    ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

  3. XM_017023320.3 → XP_016878809.1  RNA binding protein fox-1 homolog 1 isoform X3

    UniProtKB/TrEMBL
    F8VRS4
    Conserved Domains (4) summary
    PHA03193
    Location:88 → 155
    PHA03193; tegument protein VP11/12; Provisional
    COG0724
    Location:143 → 243
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:160 → 235
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:296 → 383
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  4. XM_017023321.3 → XP_016878810.1  RNA binding protein fox-1 homolog 1 isoform X4

    UniProtKB/TrEMBL
    F8VRS4
    Conserved Domains (3) summary
    PRK03427
    Location:26 → 158
    PRK03427; cell division protein ZipA; Provisional
    cd12407
    Location:153 → 228
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:289 → 378
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  5. XM_024450305.2 → XP_024306073.1  RNA binding protein fox-1 homolog 1 isoform X7

    UniProtKB/TrEMBL
    F8VRS4
    Conserved Domains (3) summary
    cd12407
    Location:153 → 228
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:262 → 350
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cl27169
    Location:26 → 158
    ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

  6. XM_005255391.5 → XP_005255448.1  RNA binding protein fox-1 homolog 1 isoform X9

    See identical proteins and their annotated locations for XP_005255448.1

    UniProtKB/TrEMBL
    A0A6Q8PFM4
    Conserved Domains (3) summary
    PRK03427
    Location:4 → 122
    PRK03427; cell division protein ZipA; Provisional
    cd12407
    Location:117 → 192
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:253 → 342
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  7. XM_047434244.1 → XP_047290200.1  RNA binding protein fox-1 homolog 1 isoform X9

  8. XM_005255386.5 → XP_005255443.1  RNA binding protein fox-1 homolog 1 isoform X5

    UniProtKB/TrEMBL
    A0A6Q8PFM4
    Conserved Domains (4) summary
    PHA03193
    Location:70 → 137
    PHA03193; tegument protein VP11/12; Provisional
    COG0724
    Location:125 → 225
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:142 → 217
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:278 → 365
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  9. XM_005255387.5 → XP_005255444.1  RNA binding protein fox-1 homolog 1 isoform X6

    See identical proteins and their annotated locations for XP_005255444.1

    UniProtKB/TrEMBL
    A0A6Q8PFM4
    Conserved Domains (3) summary
    TIGR01661
    Location:25 → 208
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    pfam12414
    Location:273 → 360
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:137 → 212
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  10. XM_024450306.2 → XP_024306074.1  RNA binding protein fox-1 homolog 1 isoform X10

    UniProtKB/TrEMBL
    B7Z608
    Conserved Domains (3) summary
    PRK14971
    Location:19 → 187
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam12414
    Location:242 → 331
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cl17169
    Location:137 → 176
    RRM_SF; RNA recognition motif (RRM) superfamily

  11. XM_047434249.1 → XP_047290205.1  RNA binding protein fox-1 homolog 1 isoform X11

  12. XM_047434243.1 → XP_047290199.1  RNA binding protein fox-1 homolog 1 isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    5269380..7744948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380514.1 → XP_054236489.1  RNA binding protein fox-1 homolog 1 isoform X1

  2. XM_054380515.1 → XP_054236490.1  RNA binding protein fox-1 homolog 1 isoform X2

  3. XM_054380516.1 → XP_054236491.1  RNA binding protein fox-1 homolog 1 isoform X3

  4. XM_054380520.1 → XP_054236495.1  RNA binding protein fox-1 homolog 1 isoform X7

  5. XM_054380517.1 → XP_054236492.1  RNA binding protein fox-1 homolog 1 isoform X4

  6. XM_054380523.1 → XP_054236498.1  RNA binding protein fox-1 homolog 1 isoform X9

  7. XM_054380521.1 → XP_054236496.1  RNA binding protein fox-1 homolog 1 isoform X12

  8. XM_054380518.1 → XP_054236493.1  RNA binding protein fox-1 homolog 1 isoform X5

  9. XM_054380519.1 → XP_054236494.1  RNA binding protein fox-1 homolog 1 isoform X6

  10. XM_054380524.1 → XP_054236499.1  RNA binding protein fox-1 homolog 1 isoform X10

  11. XM_054380526.1 → XP_054236501.1  RNA binding protein fox-1 homolog 1 isoform X13

  12. XM_054380522.1 → XP_054236497.1  RNA binding protein fox-1 homolog 1 isoform X8

  13. XM_054380525.1 → XP_054236500.1  RNA binding protein fox-1 homolog 1 isoform X11

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NWB1.2 GenPept UniProtKB/Swiss-Prot:Q9NWB1

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