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pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 [ Danio rerio (zebrafish) ]

Gene ID: 548346, updated on 11-Apr-2024

Summary

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Official Symbol
pik3c3provided by ZNC
Official Full Name
phosphatidylinositol 3-kinase, catalytic subunit type 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-050410-13
See related
Ensembl:ENSDARG00000054829 AllianceGenome:ZFIN:ZDB-GENE-050410-13
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7147158; wu:fc13g06; wu:fz51e12; zgc:112016; zgc:113009
Summary
Predicted to enable 1-phosphatidylinositol-3-kinase activity. Predicted to be involved in several processes, including autophagosome assembly; phosphatidylinositol-3-phosphate biosynthetic process; and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within phosphorylation. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in several cellular components, including endosome; peroxisome; and phagophore assembly site. Used to study inflammatory bowel disease. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See pik3c3 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (24593255..24621728, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (24322098..24350539, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene si:dkeyp-75h12.7 Neighboring gene uncharacterized LOC108190666 Neighboring gene microseminoprotein, prostate associated 1 Neighboring gene GP1 homolog, RAB6A GEF complex partner 1 Neighboring gene glucosidase, beta (bile acid) 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish. Zhao S, et al. Nat Commun, 2018 Jul 6. PMID 29980668, Free PMC Article
  2. The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation. Wang Y, et al. Redox Biol, 2020 Jan. PMID 31539803, Free PMC Article
  3. Identification of Potentially Relevant Genes for Excessive Exercise-Induced Pathological Cardiac Hypertrophy in Zebrafish. Zhou Z, et al. Front Physiol, 2020. PMID 33329019, Free PMC Article
  4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results not only reveal a role of PIK3C3 in gut homeostasis, but also provide a zebrafish inflammatory bowel disease model.
    Title: Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC191642

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy of peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphatidylinositol 3-kinase complex, class III, type I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphatidylinositol 3-kinase complex, class III, type II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol 3-kinase catalytic subunit type 3
Names
phosphoinositide-3-kinase, class 3
NP_001315462.1
XP_021333200.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328533.1 → NP_001315462.1  phosphatidylinositol 3-kinase catalytic subunit type 3

    Status: VALIDATED

    Source sequence(s)
    BX510349, EH542626, EH563762
    UniProtKB/TrEMBL
    A0A8M1P518, F1Q9F3
    Related
    ENSDARP00000092039.3, ENSDART00000101265.5
    Conserved Domains (3) summary
    cd08397
    Location:25 → 185
    C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)
    cd00870
    Location:282 → 494
    PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...
    cd00896
    Location:530 → 874
    PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase

RNA

  1. NR_137316.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BX510349
    Related
    ENSDART00000127155.4

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    24593255..24621728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021477525.1 → XP_021333200.1  phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QGZ6
    Conserved Domains (3) summary
    cd08397
    Location:25 → 194
    C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)
    cd00870
    Location:291 → 503
    PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...
    cd00896
    Location:539 → 883
    PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001017550.2: Suppressed sequence

    Description
    NM_001017550.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version

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