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PPP1CB protein phosphatase 1 catalytic subunit beta [ Homo sapiens (human) ]

Gene ID: 5500, updated on 7-Apr-2024

Summary

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Official Symbol
PPP1CBprovided by HGNC
Official Full Name
protein phosphatase 1 catalytic subunit betaprovided by HGNC
Primary source
HGNC:HGNC:9282
See related
Ensembl:ENSG00000213639 MIM:600590; AllianceGenome:HGNC:9282
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MP; PP1B; PP1c; NSLH2; PP-1B; PPP1CD; PP1beta; PPP1beta; HEL-S-80p
Summary
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 80.9), prostate (RPKM 58.5) and 25 other tissues See more
Orthologs
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Genomic context

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See PPP1CB in Genome Data Viewer
Location:
2p23.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (28751604..28802940)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (28795220..28846552)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (28974470..29025806)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11701 Neighboring gene RNA, 5S ribosomal pseudogene 89 Neighboring gene uncharacterized LOC100505774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:28945848-28946348 Neighboring gene MPRA-validated peak3641 silencer Neighboring gene PPP1CB divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11311 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:28974622-28975266 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:28978040-28978253 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11313 Neighboring gene speedy/RINGO cell cycle regulator family member A Neighboring gene tRNA methyltransferase 61B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:29091169-29091684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:29091685-29092199 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:29092829-29093353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15527 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:29105260-29105423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11315 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:29117677-29118300 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:29118301-29118922 Neighboring gene WD repeat domain 43 Neighboring gene small nucleolar RNA, C/D box 92

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The expression and clinical prognostic value of protein phosphatase 1 catalytic subunit beta in pancreatic cancer. Hu L, et al. Bioengineered, 2021 Dec. PMID 34125004, Free PMC Article
  2. Noonan syndrome with loose anagen hair with variants in the PPP1CB gene: First familial case reported. Huckstadt V, et al. Am J Med Genet A, 2021 Apr. PMID 33491856
  3. A case report of Noonan syndrome-like disorder with loose anagen hair 2 treated with recombinant human growth hormone. Zhou P, et al. Am J Med Genet A, 2020 Aug. PMID 32476286
  4. Integrative genomics analysis of eQTL and GWAS summary data identifies PPP1CB as a novel bone mineral density risk genes. Zhai Y, et al. Biosci Rep, 2020 Apr 30. PMID 32266926, Free PMC Article
  5. The recurrent PPP1CB mutation p.Pro49Arg in an additional Noonan-like syndrome individual: Broadening the clinical phenotype. Bertola D, et al. Am J Med Genet A, 2017 Mar. PMID 28211982

See all (251) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PP-1beta and PP-2Aalpha modulate cAMP response element-binding protein (CREB) functions in aging control and stress response through de-regulation of alphaB-crystallin gene and p300-p53 signaling axis.
    Title: PP-1β and PP-2Aα modulate cAMP response element-binding protein (CREB) functions in aging control and stress response through de-regulation of αB-crystallin gene and p300-p53 signaling axis.
  2. The expression and clinical prognostic value of protein phosphatase 1 catalytic subunit beta in pancreatic cancer.
    Title: The expression and clinical prognostic value of protein phosphatase 1 catalytic subunit beta in pancreatic cancer.
  3. Activating MRAS mutations cause Noonan syndrome associated with hypertrophic cardiomyopathy.
    Title: Activating MRAS mutations cause Noonan syndrome associated with hypertrophic cardiomyopathy.
  4. Noonan syndrome with loose anagen hair with variants in the PPP1CB gene: First familial case reported.
    Title: Noonan syndrome with loose anagen hair with variants in the PPP1CB gene: First familial case reported.
  5. A case report of Noonan syndrome-like disorder with loose anagen hair 2 treated with recombinant human growth hormone.
    Title: A case report of Noonan syndrome-like disorder with loose anagen hair 2 treated with recombinant human growth hormone.
  6. Integrative genomics analysis of eQTL and GWAS summary data identifies PPP1CB as a novel bone mineral density risk genes.
    Title: Integrative genomics analysis of eQTL and GWAS summary data identifies PPP1CB as a novel bone mineral density risk genes.
  7. The association of MYPT1 with PP1cbeta was profoundly reduced in the presence of excess TIMAP, leading to proteasomal MYPT1 degradation.
    Title: TIMAP inhibits endothelial myosin light chain phosphatase by competing with MYPT1 for the catalytic protein phosphatase 1 subunit PP1cβ.
  8. our experiments support that PPP1CB and KPC2 together inhibit the activity of HOXA2 by activating its nuclear export, but favored HOXA2 de-ubiquitination and stabilization thereby establishing a store of HOXA2 in the cytoplasm.
    Title: HOXA2 activity regulation by cytoplasmic relocation, protein stabilization and post-translational modification.
  9. PPP1CB mutation is associated with Noonan syndrome.
    Title: Delineation of LZTR1 mutation-positive patients with Noonan syndrome and identification of LZTR1 binding to RAF1-PPP1CB complexes.
  10. This report gives further support that this novel RASopathy-PPP1CB-related Noonan syndrome with loose anagen hair-shares great similarity to Noonan syndrome-like disorder with loose anagen hair, and expands the phenotypic spectrum by adding the cranial vault abnormality.
    Title: The recurrent PPP1CB mutation p.Pro49Arg in an additional Noonan-like syndrome individual: Broadening the clinical phenotype.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Noonan syndrome-like disorder with loose anagen hair 2
MedGen: C4479577 OMIM: 617506 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120 PubMed
Tat tat Protein phosphatase 1, catalytic subunit, beta isoform (PPP1CB) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
tat Small molecular compounds prevent the interaction of HIV-1 Tat with protein phosphatase-1 (PP1) and the shuttling of PP1 to the nucleus PubMed
tat PP1 interacts with Tat in part through the binding of Val(36) and Phe(38) of Tat to PP1, and Tat is involved in the nuclear and subnuclear targeting of PP1 PubMed
tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat Stimulation of HIV-1 Tat transactivation by protein phosphatase 1 (PP1) is inhibited by nuclear inhibitor of PP1 (NIPP1), indicating Tat function is regulated by PP1/NIPP1 PubMed
tat Protein phosphatase 1 (PP1) associates with HIV-1 Tat and stimulates Tat-mediated transactivation of the HIV-1 LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: SPDYA

Homology

Clone Names

  • MGC3672

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables myosin-light-chain-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade TAS
Traceable Author Statement
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in entrainment of circadian clock by photoperiod ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of PTW/PP1 phosphatase complex IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase PP1-beta catalytic subunit
Names
epididymis secretory sperm binding protein Li 80p
myosin phosphatase
protein phosphatase 1, catalytic subunit, beta isozyme
protein phosphatase 1-beta
protein phosphatase 1-delta
NP_002700.1
NP_996759.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052878.1 RefSeqGene

    Range
    5083..56193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002709.3 → NP_002700.1  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform 1

    See identical proteins and their annotated locations for NP_002700.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. It encodes the longer isoform (1).
    Source sequence(s)
    BC002697, BE047402, BM835970, BX477003, BX647295, CD722576, X80910
    Consensus CDS
    CCDS33169.1
    UniProtKB/Swiss-Prot
    B2R5V4, D6W565, P37140, P62140, Q5U087, Q6FG45
    UniProtKB/TrEMBL
    A0A8V8TQ71, V9HW04
    Related
    ENSP00000378769.2, ENST00000395366.3
    Conserved Domains (1) summary
    cd07414
    Location:7 → 297
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

  2. NM_206876.2 → NP_996759.1  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform 1

    See identical proteins and their annotated locations for NP_996759.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
    Source sequence(s)
    AC097724, AF092905, BE047402, BI551898, BM835970, BQ933435, CB111140, CD656807, CD722576, X80910
    Consensus CDS
    CCDS33169.1
    UniProtKB/Swiss-Prot
    B2R5V4, D6W565, P37140, P62140, Q5U087, Q6FG45
    UniProtKB/TrEMBL
    A0A8V8TQ71, V9HW04
    Related
    ENSP00000414918.2, ENST00000441461.6
    Conserved Domains (1) summary
    cd07414
    Location:7 → 297
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    28751604..28802940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    28795220..28846552
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_206877.1: Suppressed sequence

    Description
    NM_206877.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62140.3 GenPept UniProtKB/Swiss-Prot:P62140

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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