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PPP1CC protein phosphatase 1 catalytic subunit gamma [ Homo sapiens (human) ]

Gene ID: 5501, updated on 4-Jan-2025

Summary

Official Symbol
PPP1CCprovided by HGNC
Official Full Name
protein phosphatase 1 catalytic subunit gammaprovided by HGNC
Primary source
HGNC:HGNC:9283
See related
Ensembl:ENSG00000186298 MIM:176914; AllianceGenome:HGNC:9283
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP1C; PP-1G; PPP1G
Summary
The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in duodenum (RPKM 77.6), small intestine (RPKM 62.4) and 25 other tissues See more
Orthologs
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Genomic context

See PPP1CC in Genome Data Viewer
Location:
12q24.11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (110708376..110742891, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (110686068..110720600, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (111157485..111180696, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 387, pseudogene Neighboring gene tectonic family member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:111099215-111099717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7016 Neighboring gene uncharacterized LOC124903017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7019 Neighboring gene hydrogen voltage gated channel 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:111124990-111125818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4859 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7026 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:111180421-111180929 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:111181691-111182275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7027 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:111218408-111218569 Neighboring gene CRISPRi-validated cis-regulatory element chr12.3641 Neighboring gene NANOG hESC enhancer GRCh37_chr12:111246997-111247498 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:111251419-111251918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7028 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:111290753-111291952 Neighboring gene ribosomal protein L29 pseudogene 25 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:111298099-111298599 Neighboring gene coiled-coil domain containing 63

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Small molecular compounds prevent the interaction of HIV-1 Tat with protein phosphatase-1 (PP1) and the shuttling of PP1 to the nucleus PubMed
tat PP1 interacts with Tat in part through the binding of Val(36) and Phe(38) of Tat to PP1, and Tat is involved in the nuclear and subnuclear targeting of PP1 PubMed
tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat Stimulation of HIV-1 Tat transactivation by protein phosphatase 1 (PP1) is inhibited by nuclear inhibitor of PP1 (NIPP1), indicating Tat function is regulated by PP1/NIPP1 PubMed
tat Protein phosphatase 1 (PP1) associates with HIV-1 Tat and stimulates Tat-mediated transactivation of the HIV-1 LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MAP kinase serine/threonine phosphatase activity  
enables RNA binding PubMed 
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity  
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity  
enables calmodulin-dependent protein phosphatase activity  
enables histone H2AXS140 phosphatase activity  
enables lamin binding  
enables metal ion binding  
enables myosin phosphatase activity  
enables phosphatase activity  
enables phosphoprotein phosphatase activity  
enables protein binding PubMed 
enables protein binding PubMed 
enables protein domain specific binding  
enables protein kinase binding PubMed 
enables protein phosphatase 1 binding  
enables protein serine/threonine phosphatase activity  
enables protein serine/threonine phosphatase activity PubMed 
enables protein serine/threonine phosphatase activity PubMed 
enables protein serine/threonine phosphatase activity  
enables protein-containing complex binding  
Process Evidence Code Pubs
involved_in MAPK cascade  
involved_in blastocyst development  
involved_in cell division  
involved_in chromatin remodeling  
involved_in circadian regulation of gene expression  
involved_in entrainment of circadian clock by photoperiod  
involved_in glycogen metabolic process  
involved_in mitotic sister chromatid segregation  
involved_in neuron differentiation  
involved_in positive regulation of glial cell proliferation  
acts_upstream_of_or_within protein dephosphorylation PubMed 
involved_in protein dephosphorylation  
involved_in regulation of circadian rhythm PubMed 
involved_in regulation of nucleocytoplasmic transport  
involved_in regulation of transcription by RNA polymerase II  
involved_in spermatogenesis  
Items 1 - 20 of 21
Component Evidence Code Pubs
part_of PTW/PP1 phosphatase complex PubMed 
colocalizes_with chromosome, telomeric region PubMed 
located_in cleavage furrow  
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytosol  
located_in dendritic spine  
located_in focal adhesion PubMed 
located_in glutamatergic synapse  
located_in kinetochore  
located_in microtubule organizing center  
located_in midbody  
located_in mitochondrial outer membrane  
located_in mitochondrion PubMed 
located_in nuclear speck  
located_in nucleolus PubMed 
located_in nucleus PubMed 
is_active_in nucleus  
located_in nucleus PubMed 
located_in presynapse  
part_of protein-containing complex PubMed 
Items 1 - 20 of 21

General protein information

Preferred Names
serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Names
protein phosphatase 1, catalytic subunit, gamma isozyme
protein phosphatase 1C catalytic subunit
serine/threonine phosphatase 1 gamma
NP_001231903.1
NP_002701.1
XP_011536806.1
XP_011536807.1
XP_054228341.1
XP_054228342.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030325.2 RefSeqGene

    Range
    5000..28211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001244974.2NP_001231903.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 2

    See identical proteins and their annotated locations for NP_001231903.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs at the 3' end compared to variant 1. This results in a longer isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA781342, AW575661, BC014073, DA514523
    Consensus CDS
    CCDS58279.1
    UniProtKB/TrEMBL
    Q9UPN1
    Related
    ENSP00000341779.5, ENST00000340766.9
    Conserved Domains (1) summary
    cd07414
    Location:8298
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
  2. NM_002710.4NP_002701.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1

    See identical proteins and their annotated locations for NP_002701.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.
    Source sequence(s)
    AC144522, AW575661, BC014073, DA514523, X74008
    Consensus CDS
    CCDS9150.1
    UniProtKB/Swiss-Prot
    P36873
    UniProtKB/TrEMBL
    Q9UPN1
    Related
    ENSP00000335084.5, ENST00000335007.10
    Conserved Domains (1) summary
    cd07414
    Location:8298
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    110708376..110742891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538505.4XP_011536807.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X2

    UniProtKB/TrEMBL
    Q9UPN1
    Conserved Domains (2) summary
    PTZ00480
    Location:6313
    PTZ00480; serine/threonine-protein phosphatase; Provisional
    cd07414
    Location:8298
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
  2. XM_011538504.4XP_011536806.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1

    UniProtKB/TrEMBL
    Q9UPN1
    Conserved Domains (2) summary
    PTZ00480
    Location:6315
    PTZ00480; serine/threonine-protein phosphatase; Provisional
    cd07414
    Location:8298
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

RNA

  1. XR_007063094.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    110686068..110720600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372367.1XP_054228342.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X2

    UniProtKB/TrEMBL
    Q9UPN1
  2. XM_054372366.1XP_054228341.1  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1

    UniProtKB/TrEMBL
    Q9UPN1

RNA

  1. XR_008488626.1 RNA Sequence

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