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mcur1 mitochondrial calcium uniporter regulator 1 [ Danio rerio (zebrafish) ]

Gene ID: 550408, updated on 11-Apr-2024

Summary

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Official Symbol
mcur1provided by ZNC
Official Full Name
mitochondrial calcium uniporter regulator 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-213
See related
Ensembl:ENSDARG00000016964 AllianceGenome:ZFIN:ZDB-GENE-050417-213
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7054683; wu:fb37a05; zgc:112190; zgc:165532
Summary
Predicted to be involved in calcium import into the mitochondrion and positive regulation of mitochondrial calcium ion concentration. Predicted to act upstream of or within mitochondrial calcium ion transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Predicted to be integral component of mitochondrial inner membrane. Orthologous to human MCUR1 (mitochondrial calcium uniporter regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (41313571..41318205)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (41034788..41038132)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene si:dkey-86l18.10 Neighboring gene regulator of G protein signaling 9 binding protein Neighboring gene diphthamide biosynthesis 2 Neighboring gene neutrophil cytosolic factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in pink1(-/-) zebrafish. Soman S, et al. Eur J Neurosci, 2017 Feb. PMID 27859782, Free PMC Article
  2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables isocitrate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitochondrial calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitochondrial calcium uniporter regulator 1
NP_001338730.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351801.1 → NP_001338730.1  mitochondrial calcium uniporter regulator 1

    Status: VALIDATED

    Source sequence(s)
    CT574559, EH502903, EH552741, EH573865
    UniProtKB/TrEMBL
    A0A8M1PAJ3, F1Q729
    Related
    ENSDARP00000021989.4, ENSDART00000016660.6
    Conserved Domains (1) summary
    pfam07798
    Location:65 → 256
    DUF1640; Protein of unknown function (DUF1640)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    41313571..41318205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001017713.1: Suppressed sequence

    Description
    NM_001017713.1: This RefSeq was removed because it is based on a chimeric transcript.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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