PPP2CB protein phosphatase 2 catalytic subunit beta [Homo sapiens (human)] - Gene

Summary

Official Symbol: PPP2CBprovided by HGNC
Official Full Name: protein phosphatase 2 catalytic subunit betaprovided by HGNC
Primary source: HGNC:HGNC:9300
See related: Ensembl:ENSG00000104695 MIM:176916; AllianceGenome:HGNC:9300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PP2CB; PP2Abeta
Summary: This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
Expression: Ubiquitous expression in brain (RPKM 83.4), thyroid (RPKM 78.1) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (30785616..30812818, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (31066636..31093832, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (30643132..30670334, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE varepsilon2 for Alzheimer's disease.
Title: Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease.
Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities.
Title: Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities.
The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability
Title: The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability.
These data strongly support a recent proposal that a segment at 8p21.3 contains crucial prostate cancer tumor suppressors.
Title: Protein phosphatase and TRAIL receptor genes as new candidate tumor genes on chromosome 8p in prostate cancer.
PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling.
Title: PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling.
Claspin may be one of the phosphoproteins through which PP2A(Aalpha/Cbeta) affects Chk1 phosphorylation when ATR is activated by human immunodeficiency virus-1 Vpr.
Title: Phosphatase type 2A-dependent and -independent pathways for ATR phosphorylation of Chk1.
Results describe the cell cycle expression, subcellular distribution, and metabolic stability of protein phosphatase 2Abeta in comparison with 2Aalpha.
Title: Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pol	gag-pol	HIV-1 Pol is identified to have a physical interaction with protein phosphatase 2, catalytic subunit, beta isozyme (PPP2CB) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
Tat	tat	HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells	PubMed
	tat	An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression	PubMed
Vpr	vpr	Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain	PubMed
	vpr	HIV-1 Vpr was found to upregulate PP2A in fission yeast	PubMed
	vpr	HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A	PubMed
Vpu	vpu	IFN-alpha and IFN-beta increases SCYL2 expression and the increase induces PP2A-mediated dephosphorylation of Vpu, suggesting that SCYL2 affects Vpu function through a phosphorylation-dependent mechanism	PubMed
nucleocapsid	gag	HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2038 (e-PCR)
- UniSTS:50192

PPP2CB_3846 (e-PCR)
- UniSTS:462449

G20287 (e-PCR)
- UniSTS:42878

A005K33 (e-PCR)
- UniSTS:42879

D8S1928 (e-PCR)
- UniSTS:34176

RH46279 (e-PCR)
- UniSTS:698

STS-N68423 (e-PCR)
- UniSTS:73971

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine phosphatase activity	TAS Traceable Author Statement more info	PubMed
enables tau protein binding	NAS Non-traceable Author Statement more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic mitochondrial changes	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of NF-kappaB transcription factor activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of tumor necrosis factor-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidyl-serine dephosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in peptidyl-threonine dephosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein dephosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in response to antibiotic	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in response to lead ion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein phosphatase type 2A complex	TAS Traceable Author Statement more info	PubMed
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

Names: PP2A-beta; protein phosphatase 2, catalytic subunit, beta isozyme; protein phosphatase type 2A catalytic subunit; testicular tissue protein Li 146

NP_001009552.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009552.2 → NP_001009552.1 serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

See identical proteins and their annotated locations for NP_001009552.1

Status: REVIEWED

Source sequence(s)

AC009314, BC012022, BG716837, CA419001, CF594136

Consensus CDS

CCDS6079.1

UniProtKB/Swiss-Prot

D3DSV4, P11082, P62714, Q6FHK5

UniProtKB/TrEMBL

A0A140VJS0, B3KRM2, Q5U0I7

Related

ENSP00000221138.4, ENST00000221138.9

Conserved Domains (1) summary

cd07415
Location:9 → 293

MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

30785616..30812818 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060932.1 Alternate T2T-CHM13v2.0

Range

31066636..31093832 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_004156.2: Suppressed sequence

Description

NM_004156.2: This RefSeq was permanently suppressed because currently there is not sufficient data to support a splice pattern with non-consensus splice sites in the 5' UTR.