These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

1. NG_050860.2 RefSeqGene

   Range

   31265..189436

   Download

   GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. NM_001011722.2 → NP_001011722.2  rho guanine nucleotide exchange factor 10-like protein isoform 2

   See identical proteins and their annotated locations for NP_001011722.2

   Status: REVIEWED

   Description

   Transcript Variant: This variant (2) lacks an in-frame exon, as compared to variant 1. The encoded isoform 2 thus lacks an internal segment, as compared to isoform 1.

   Source sequence(s)

   AB046846, AK092020, AW455769, BC080596

   Consensus CDS

   CCDS30617.1

   UniProtKB/TrEMBL

   A0A2X0U2F8

   Related

   ENSP00000364564.1, ENST00000375415.5

   Conserved Domains (3) summary

   pfam00621
   Location:285 → 463

   RhoGEF; RhoGEF domain

   sd00039
   Location:888 → 931

   7WD40; WD40 repeat [structural motif]

   cl02567
   Location:861 → 1011

   WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

2. NM_001319837.1 → NP_001306766.1  rho guanine nucleotide exchange factor 10-like protein isoform 3

   Status: REVIEWED

   Description

   Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. It encodes isoform 3, which lacks two separate internal in-frame segments and is shorter than isoform 1.

   Source sequence(s)

   AB046846, BC111058, BU738615, DQ139833

   UniProtKB/TrEMBL

   A0A2X0U2F8

   Conserved Domains (3) summary

   pfam00621
   Location:285 → 463

   RhoGEF; RhoGEF domain

   sd00039
   Location:883 → 926

   7WD40; WD40 repeat [structural motif]

   cl02567
   Location:856 → 1006

   WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

3. NM_001319838.1 → NP_001306767.1  rho guanine nucleotide exchange factor 10-like protein isoform 4

   Status: REVIEWED

   Description

   Transcript Variant: This variant (4) represents use of an alternate promoter. It differs in the 5' UTR and 5' coding region, uses an alternate start codon and lacks three alternate exons in the coding region, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct N-terminus, compared to isoform 1.

   Source sequence(s)

   AK092020, BC111058, BU738615, DA468685, DQ139833

   UniProtKB/TrEMBL

   B3KX74

   Conserved Domains (3) summary

   sd00039
   Location:630 → 673

   7WD40; WD40 repeat [structural motif]

   cl02567
   Location:603 → 753

   WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

   cl02571
   Location:102 → 210

   RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

4. NM_001328124.1 → NP_001315053.1  rho guanine nucleotide exchange factor 10-like protein isoform 5

   Status: REVIEWED

   Description

   Transcript Variant: This variant (5) represents use of an alternate promoter and contains novel 5' UTR and 5' coding region, compared to variant 1. It encodes isoform 5, which is shorter and has a distinct N-terminus, compared to isoform 1.

   Source sequence(s)

   AK092020, AK300264, BC080596, BC111058, DA468685

   UniProtKB/TrEMBL

   B3KX74

   Conserved Domains (3) summary

   pfam00621
   Location:102 → 280

   RhoGEF; RhoGEF domain

   sd00039
   Location:705 → 748

   7WD40; WD40 repeat [structural motif]

   cl02567
   Location:678 → 828

   WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

5. NM_018125.4 → NP_060595.3  rho guanine nucleotide exchange factor 10-like protein isoform 1

   See identical proteins and their annotated locations for NP_060595.3

   Status: REVIEWED

   Description

   Transcript Variant: This variant (1) encodes the longer isoform (1).

   Source sequence(s)

   AB046846, AK092020, AL390994, AW455769, BC065561

   Consensus CDS

   CCDS182.1

   UniProtKB/Swiss-Prot

   B7ZKS1, Q17RW1, Q3YFJ4, Q5VXI5, Q5VXI6, Q66K51, Q6P0L7, Q8NAV5, Q9HCE6, Q9NVT3

   UniProtKB/TrEMBL

   A0A2X0U2F8

   Related

   ENSP00000355060.3, ENST00000361221.8

   Conserved Domains (2) summary

   cd00160
   Location:317 → 501

   RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

   sd00039
   Location:927 → 970

   7WD40; WD40 repeat [structural motif]

RNA

1. NR_137287.2 RNA Sequence

   Status: REVIEWED

   Description

   Transcript Variant: This variant (6) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

   Source sequence(s)

   AB046846, AK092020, AL358593, AL390994, BC111058

2. NR_137288.2 RNA Sequence

   Status: REVIEWED

   Description

   Transcript Variant: This variant (7) lacks an alternate internal exon and contains an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

   Source sequence(s)

   AB046846, AK092020, AL358593, AL390994, BC111058

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCh38.p14 Primary Assembly

Genomic

1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

   Range

   17513435..17697875

   Download

   GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. XM_024448061.2 → XP_024303829.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

   UniProtKB/TrEMBL

   A0A2X0U2F8

   Conserved Domains (2) summary

   cd00160
   Location:282 → 466

   RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

   sd00039
   Location:892 → 935

   7WD40; WD40 repeat [structural motif]

2. XM_006710728.1 → XP_006710791.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

   See identical proteins and their annotated locations for XP_006710791.1

   UniProtKB/TrEMBL

   A0A2X0U2F8

   Conserved Domains (2) summary

   cd00160
   Location:282 → 466

   RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

   sd00039
   Location:892 → 935

   7WD40; WD40 repeat [structural motif]

3. XM_047424089.1 → XP_047280045.1  rho guanine nucleotide exchange factor 10-like protein isoform X6

4. XM_006710731.1 → XP_006710794.1  rho guanine nucleotide exchange factor 10-like protein isoform X2

   See identical proteins and their annotated locations for XP_006710794.1

   UniProtKB/TrEMBL

   A0A2X0U2F8

   Conserved Domains (3) summary

   pfam00621
   Location:288 → 466

   RhoGEF; RhoGEF domain

   sd00039
   Location:891 → 934

   7WD40; WD40 repeat [structural motif]

   cl02567
   Location:864 → 1014

   WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

5. XM_047424111.1 → XP_047280067.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

6. XM_047424100.1 → XP_047280056.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

7. XM_047424075.1 → XP_047280031.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

8. XM_005245923.3 → XP_005245980.2  rho guanine nucleotide exchange factor 10-like protein isoform X1

   See identical proteins and their annotated locations for XP_005245980.2

   UniProtKB/TrEMBL

   A0A2X0U2F8

   Conserved Domains (2) summary

   cd00160
   Location:282 → 466

   RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

   sd00039
   Location:892 → 935

   7WD40; WD40 repeat [structural motif]

9. XM_047424093.1 → XP_047280049.1  rho guanine nucleotide exchange factor 10-like protein isoform X6

10. XM_006710729.2 → XP_006710792.1  rho guanine nucleotide exchange factor 10-like protein isoform X2

    See identical proteins and their annotated locations for XP_006710792.1

    UniProtKB/TrEMBL

    A0A2X0U2F8

    Conserved Domains (3) summary

    pfam00621
    Location:288 → 466

    RhoGEF; RhoGEF domain

    sd00039
    Location:891 → 934

    7WD40; WD40 repeat [structural motif]

    cl02567
    Location:864 → 1014

    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

11. XM_005245925.3 → XP_005245982.2  rho guanine nucleotide exchange factor 10-like protein isoform X4

    See identical proteins and their annotated locations for XP_005245982.2

    UniProtKB/TrEMBL

    A0A2X0U2F8

    Conserved Domains (3) summary

    pfam00621
    Location:285 → 463

    RhoGEF; RhoGEF domain

    sd00039
    Location:888 → 931

    7WD40; WD40 repeat [structural motif]

    cl02567
    Location:861 → 1011

    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

12. XM_017001617.2 → XP_016857106.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

    UniProtKB/TrEMBL

    A0A2X0U2F8

    Conserved Domains (3) summary

    pfam00621
    Location:285 → 463

    RhoGEF; RhoGEF domain

    sd00039
    Location:883 → 926

    7WD40; WD40 repeat [structural motif]

    cl02567
    Location:856 → 1006

    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

13. XM_047424065.1 → XP_047280021.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

14. XM_047424097.1 → XP_047280053.1  rho guanine nucleotide exchange factor 10-like protein isoform X6

15. XM_047424112.1 → XP_047280068.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

16. XM_047424071.1 → XP_047280027.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

17. XM_047424070.1 → XP_047280026.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

18. XM_024448059.2 → XP_024303827.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

    UniProtKB/TrEMBL

    A0A2X0U2F8

    Conserved Domains (2) summary

    cd00160
    Location:282 → 466

    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    sd00039
    Location:892 → 935

    7WD40; WD40 repeat [structural motif]

19. XM_047424098.1 → XP_047280054.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

20. XM_024448062.1 → XP_024303830.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

    UniProtKB/TrEMBL

    A0A2X0U2F8

    Conserved Domains (2) summary

    cd00160
    Location:282 → 466

    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    sd00039
    Location:892 → 935

    7WD40; WD40 repeat [structural motif]

21. XM_047424096.1 → XP_047280052.1  rho guanine nucleotide exchange factor 10-like protein isoform X6

22. XM_047424105.1 → XP_047280061.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

23. XM_011541692.3 → XP_011539994.1  rho guanine nucleotide exchange factor 10-like protein isoform X5

    UniProtKB/TrEMBL

    A0A2X0U2F8

    Conserved Domains (3) summary

    pfam00621
    Location:289 → 467

    RhoGEF; RhoGEF domain

    sd00039
    Location:887 → 930

    7WD40; WD40 repeat [structural motif]

    cl02567
    Location:860 → 1010

    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

24. XM_011541691.3 → XP_011539993.1  rho guanine nucleotide exchange factor 10-like protein isoform X3

    UniProtKB/TrEMBL

    A0A2X0U2F8

    Conserved Domains (3) summary

    pfam00621
    Location:286 → 464

    RhoGEF; RhoGEF domain

    sd00039
    Location:889 → 932

    7WD40; WD40 repeat [structural motif]

    cl02567
    Location:862 → 1012

    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

25. XM_017001619.2 → XP_016857108.1  rho guanine nucleotide exchange factor 10-like protein isoform X9

26. XM_017001620.2 → XP_016857109.1  rho guanine nucleotide exchange factor 10-like protein isoform X10

27. XM_047424158.1 → XP_047280114.1  rho guanine nucleotide exchange factor 10-like protein isoform X11

28. XM_047424175.1 → XP_047280131.1  rho guanine nucleotide exchange factor 10-like protein isoform X15

29. XM_047424159.1 → XP_047280115.1  rho guanine nucleotide exchange factor 10-like protein isoform X12

30. XM_047424190.1 → XP_047280146.1  rho guanine nucleotide exchange factor 10-like protein isoform X16

31. XM_047424165.1 → XP_047280121.1  rho guanine nucleotide exchange factor 10-like protein isoform X13

32. XM_047424167.1 → XP_047280123.1  rho guanine nucleotide exchange factor 10-like protein isoform X14

33. XM_047424201.1 → XP_047280157.1  rho guanine nucleotide exchange factor 10-like protein isoform X17

34. XM_005245929.4 → XP_005245986.2  rho guanine nucleotide exchange factor 10-like protein isoform X8

    UniProtKB/TrEMBL

    B3KX74, Q5VXI4

    Related

    ENSP00000364557.3, ENST00000375408.7

    Conserved Domains (3) summary

    pfam00621
    Location:102 → 280

    RhoGEF; RhoGEF domain

    sd00039
    Location:700 → 743

    7WD40; WD40 repeat [structural motif]

    cl02567
    Location:673 → 823

    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

1. XR_946686.4 RNA Sequence

2. XR_946691.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

1. NC_060925.1 Alternate T2T-CHM13v2.0

   Range

   17327447..17513168

   Download

   GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. XM_054337380.1 → XP_054193355.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

2. XM_054337377.1 → XP_054193352.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

3. XM_054337389.1 → XP_054193364.1  rho guanine nucleotide exchange factor 10-like protein isoform X6

4. XM_054337384.1 → XP_054193359.1  rho guanine nucleotide exchange factor 10-like protein isoform X2

5. XM_054337396.1 → XP_054193371.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

6. XM_054337394.1 → XP_054193369.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

7. XM_054337383.1 → XP_054193358.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

8. XM_054337376.1 → XP_054193351.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

9. XM_054337390.1 → XP_054193365.1  rho guanine nucleotide exchange factor 10-like protein isoform X6

10. XM_054337385.1 → XP_054193360.1  rho guanine nucleotide exchange factor 10-like protein isoform X2

11. XM_054337387.1 → XP_054193362.1  rho guanine nucleotide exchange factor 10-like protein isoform X4

12. XM_054337398.1 → XP_054193373.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

13. XM_054337375.1 → XP_054193350.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

14. XM_054337392.1 → XP_054193367.1  rho guanine nucleotide exchange factor 10-like protein isoform X6

15. XM_054337397.1 → XP_054193372.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

16. XM_054337382.1 → XP_054193357.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

17. XM_054337393.1 → XP_054193368.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

18. XM_054337381.1 → XP_054193356.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

19. XM_054337378.1 → XP_054193353.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

20. XM_054337379.1 → XP_054193354.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

21. XM_054337391.1 → XP_054193366.1  rho guanine nucleotide exchange factor 10-like protein isoform X6

22. XM_054337395.1 → XP_054193370.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

23. XM_054337388.1 → XP_054193363.1  rho guanine nucleotide exchange factor 10-like protein isoform X5

24. XM_054337386.1 → XP_054193361.1  rho guanine nucleotide exchange factor 10-like protein isoform X3

25. XM_054337400.1 → XP_054193375.1  rho guanine nucleotide exchange factor 10-like protein isoform X9

26. XM_054337401.1 → XP_054193376.1  rho guanine nucleotide exchange factor 10-like protein isoform X10

27. XM_054337402.1 → XP_054193377.1  rho guanine nucleotide exchange factor 10-like protein isoform X11

28. XM_054337406.1 → XP_054193381.1  rho guanine nucleotide exchange factor 10-like protein isoform X15

29. XM_054337403.1 → XP_054193378.1  rho guanine nucleotide exchange factor 10-like protein isoform X12

30. XM_054337407.1 → XP_054193382.1  rho guanine nucleotide exchange factor 10-like protein isoform X16

31. XM_054337404.1 → XP_054193379.1  rho guanine nucleotide exchange factor 10-like protein isoform X13

32. XM_054337405.1 → XP_054193380.1  rho guanine nucleotide exchange factor 10-like protein isoform X14

33. XM_054337408.1 → XP_054193383.1  rho guanine nucleotide exchange factor 10-like protein isoform X17

34. XM_054337399.1 → XP_054193374.1  rho guanine nucleotide exchange factor 10-like protein isoform X8

RNA

1. XR_008486087.1 RNA Sequence

2. XR_008486088.1 RNA Sequence