IMP3 IMP U3 small nucleolar ribonucleoprotein 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IMP3provided by HGNC
Official Full Name: IMP U3 small nucleolar ribonucleoprotein 3provided by HGNC
Primary source: HGNC:HGNC:14497
See related: Ensembl:ENSG00000177971 MIM:612980; AllianceGenome:HGNC:14497
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BRMS2; MRPS4; C15orf12
Summary: This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. [provided by RefSeq, Jul 2008]
Annotation information: Note: IMP3 (Gene ID: 55272) and IGF2BP3 (Gene ID: 10643) share the IMP3 symbol/alias in common. IMP3 is a widely used alternative name for insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), which can be confused with the official symbol for IMP3, U3 small nucleolar ribonucleoprotein (IMP3). [17 May 2018]
Orthologs: mouse all
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Genomic context

Location:: 15q24.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (75639093..75640224, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (73509801..73510932, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (75931434..75932565, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNA-binding protein IMP3 is a novel regulator of MEK1/ERK signaling pathway in the progression of colorectal Cancer through the stabilization of MEKK1 mRNA.
Title: RNA-binding protein IMP3 is a novel regulator of MEK1/ERK signaling pathway in the progression of colorectal Cancer through the stabilization of MEKK1 mRNA.
Correlations of expressions of IMP3 and VEGF with stage of osteosarcoma, microvascular density and pulmonary metastasis.
Title: Correlations of expressions of IMP3 and VEGF with stage of osteosarcoma, microvascular density and pulmonary metastasis.
The expression of ribonuclear protein IMP3 in laryngeal carcinogenesis.
Title: The expression of ribonuclear protein IMP3 in laryngeal carcinogenesis.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-W73226 (e-PCR)
- UniSTS:14645

D15S715E (e-PCR)
- UniSTS:151615

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables rRNA binding	IEA Inferred from Electronic Annotation more info
enables snoRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in maturation of SSU-rRNA	NAS Non-traceable Author Statement more info	PubMed
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit biogenesis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of Mpp10 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Mpp10 complex	IDA Inferred from Direct Assay more info	PubMed
part_of Mpp10 complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info
part_of preribosome	IDA Inferred from Direct Assay more info	PubMed
part_of small ribosomal subunit	IEA Inferred from Electronic Annotation more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: U3 small nucleolar ribonucleoprotein protein IMP3

Names: IMP3, U3 small nucleolar ribonucleoprotein, homolog; U3 snoRNP protein 3 homolog; U3 snoRNP protein IMP3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018285.4 → NP_060755.1 U3 small nucleolar ribonucleoprotein protein IMP3

See identical proteins and their annotated locations for NP_060755.1

Status: REVIEWED

Source sequence(s)

AC105020

Consensus CDS

CCDS10282.1

UniProtKB/Swiss-Prot

B3KQ67, Q53G10, Q9NV31

Related

ENSP00000385217.1, ENST00000403490.3

Conserved Domains (1) summary

COG0522
Location:1 → 168

RpsD; Ribosomal protein S4 or related protein [Translation, ribosomal structure and biogenesis]