ppargc1a peroxisome proliferator-activated receptor gamma, coactivator 1 alpha [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ppargc1aprovided by ZNC
Official Full Name: peroxisome proliferator-activated receptor gamma, coactivator 1 alphaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080505-1
See related: Ensembl:ENSDARG00000067829 AllianceGenome:ZFIN:ZDB-GENE-080505-1
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: PGC1; PGC-1; ppargc1al; PGC-1alpha; gb:dq017637
Summary: Predicted to enable nuclear receptor coactivator activity. Acts upstream of or within late distal convoluted tubule development; proximal straight tubule development; and skeletal muscle tissue development. Predicted to be located in PML body. Predicted to be active in nucleus. Is expressed in several structures, including mesoderm; musculature system; nervous system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; neurodegenerative disease (multiple); non-alcoholic fatty liver disease; and type 2 diabetes mellitus. Orthologous to human PPARGC1A (PPARG coactivator 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (70578429..70669850, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (70128164..70219382, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exercise intervention mitigates zebrafish age-related sarcopenia via alleviating mitochondrial dysfunction.
Title: Exercise intervention mitigates zebrafish age-related sarcopenia via alleviating mitochondrial dysfunction.
Ppargc1a Controls Ciliated Cell Development by Regulating Prostaglandin Biosynthesis.
Title: Ppargc1a Controls Ciliated Cell Development by Regulating Prostaglandin Biosynthesis.
Metabolic regulation by the PGC-1alpha and PGC-1beta coactivators in larval zebrafish (Danio rerio).
Title: Metabolic regulation by the PGC-1α and PGC-1β coactivators in larval zebrafish (Danio rerio).
These data reveal new roles for Ppargc1a during development, which have implications for understanding renal birth defects.
Title: ppargc1a controls nephron segmentation during zebrafish embryonic kidney ontogeny.
The transcriptional coactivator PGC-1alpha, which has roles in the regulation of mitochondrial biogenesis and reactive-oxygen-species detoxification, abrogated alpha Synuclein toxicity in both the axon and the cell body.
Title: Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity.
This study demonistrated that WldS and PGC-1alpha regulate mitochondrial transport and oxidation state after axonal injury.
Title: WldS and PGC-1α regulate mitochondrial transport and oxidation state after axonal injury.
Role of PGC-1alpha in the control of energy metabolism and insulin sensitivity is seen as a candidate factor in the etiology of type 2 diabetes and a drug target for its therapeutic treatment.[REVIEW]
Title: PGC-1alpha and exercise: important partners in combating insulin resistance.

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Pathways from PubChem

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General gene information

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Markers

fd04e08.y1 (e-PCR)
- UniSTS:194922

fk32d09.y1 (e-PCR)
- UniSTS:200822

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info
enables transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within late distal convoluted tubule development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within late distal convoluted tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proximal straight tubule development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within proximal straight tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Names: peroxisome proliferator-activated receptor gamma, coactivator 1 alpha like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

70578429..70669850 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017357139.2 → XP_017212628.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X2

UniProtKB/TrEMBL

A0A8M6Z0A6
XM_017357138.2 → XP_017212627.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1

UniProtKB/TrEMBL

A0A8M6Z7F8
XM_017357140.2 → XP_017212629.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X4

UniProtKB/TrEMBL

A0A8M6Z1V5
XM_002667531.6 → XP_002667577.4 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X3

UniProtKB/TrEMBL

A0A8M1REN0

Related

ENSDARP00000088481.4, ENSDART00000097710.6