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LGR4 leucine rich repeat containing G protein-coupled receptor 4 [ Homo sapiens (human) ]

Gene ID: 55366, updated on 11-Apr-2024

Summary

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Official Symbol
LGR4provided by HGNC
Official Full Name
leucine rich repeat containing G protein-coupled receptor 4provided by HGNC
Primary source
HGNC:HGNC:13299
See related
Ensembl:ENSG00000205213 MIM:606666; AllianceGenome:HGNC:13299
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPSL; GPR48; BNMD17
Summary
The protein encoded by this gene is a G-protein coupled receptor that binds R-spondins and activates the Wnt signaling pathway. This Wnt signaling pathway activation is necessary for proper development of many organs of the body. [provided by RefSeq, Oct 2016]
Expression
Ubiquitous expression in kidney (RPKM 28.0), colon (RPKM 27.7) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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See LGR4 in Genome Data Viewer
Location:
11p14.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (27365961..27472790, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (27506453..27613276, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (27387508..27494337, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376601 Neighboring gene Sharpr-MPRA regulatory region 9357 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:27340270-27341469 Neighboring gene coiled-coil domain containing 34 Neighboring gene Sharpr-MPRA regulatory region 11938 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:27384156-27385023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4543 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:27462218-27462830 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:27465211-27465953 Neighboring gene Sharpr-MPRA regulatory region 4633 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:27483166-27483666 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3210 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3211 Neighboring gene LGR4 antisense RNA 1 Neighboring gene ribosomal protein L37a pseudogene 7 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:27527877-27529076 Neighboring gene lin-7 homolog C, crumbs cell polarity complex component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LGR4: A New Receptor Member in Endocrine and Metabolic Diseases. Zhang N, et al. Endocr Rev, 2023 Jul 11. PMID 36791020, Free PMC Article
  2. Bioinformatics Analysis of LGR4 in Colon Adenocarcinoma as Potential Diagnostic Biomarker, Therapeutic Target and Promoting Immune Cell Infiltration. Wu L, et al. Biomolecules, 2022 Aug 6. PMID 36008975, Free PMC Article
  3. LGR4 Gene Polymorphisms Are Associated With Bone and Obesity Phenotypes in Chinese Female Nuclear Families. Shi SQ, et al. Front Endocrinol (Lausanne), 2021. PMID 34707566, Free PMC Article
  4. The Role of LGR4 (GPR48) in Normal and Cancer Processes. Ordaz-Ramos A, et al. Int J Mol Sci, 2021 Apr 29. PMID 33946652, Free PMC Article
  5. Ablation of LGR4 signaling enhances radiation sensitivity of prostate cancer cells. Liang F, et al. Life Sci, 2021 Jan 15. PMID 33171177

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rspo2-LGR4 exacerbates hepatocellular carcinoma progression via activation of Wnt/beta-catenin signaling pathway.
    Title: Rspo2-LGR4 exacerbates hepatocellular carcinoma progression via activation of Wnt/β-catenin signaling pathway.
  2. Identification of LGR4 as a prognostic biomarker in KRAS-mutant lung adenocarcinoma: Evidence from integrated bioinformatics analysis.
    Title: Identification of LGR4 as a prognostic biomarker in KRAS-mutant lung adenocarcinoma: Evidence from integrated bioinformatics analysis.
  3. LGR4 promotes tumorigenesis by activating TGF-beta1/Smad signaling pathway in multiple myeloma.
    Title: LGR4 promotes tumorigenesis by activating TGF-β1/Smad signaling pathway in multiple myeloma.
  4. LGR4: A New Receptor Member in Endocrine and Metabolic Diseases.
    Title: LGR4: A New Receptor Member in Endocrine and Metabolic Diseases.
  5. Loss of LGR4/GPR48 causes severe neonatal salt wasting due to disrupted WNT signaling altering adrenal zonation.
    Title: Loss of LGR4/GPR48 causes severe neonatal salt wasting due to disrupted WNT signaling altering adrenal zonation.
  6. Bioinformatics Analysis of LGR4 in Colon Adenocarcinoma as Potential Diagnostic Biomarker, Therapeutic Target and Promoting Immune Cell Infiltration.
    Title: Bioinformatics Analysis of LGR4 in Colon Adenocarcinoma as Potential Diagnostic Biomarker, Therapeutic Target and Promoting Immune Cell Infiltration.
  7. RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis.
    Title: RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis.
  8. Clinical Significance of Stem Cell Biomarkers EpCAM, LGR5 and LGR4 mRNA Levels in Lymph Nodes of Colon Cancer Patients.
    Title: Clinical Significance of Stem Cell Biomarkers EpCAM, LGR5 and LGR4 mRNA Levels in Lymph Nodes of Colon Cancer Patients.
  9. LGR4 Gene Polymorphisms Are Associated With Bone and Obesity Phenotypes in Chinese Female Nuclear Families.
    Title: LGR4 Gene Polymorphisms Are Associated With Bone and Obesity Phenotypes in Chinese Female Nuclear Families.
  10. LGR4, Not LGR5, Enhances hPSC Hematopoiesis by Facilitating Mesoderm Induction via TGF-Beta Signaling Activation.
    Title: LGR4, Not LGR5, Enhances hPSC Hematopoiesis by Facilitating Mesoderm Induction via TGF-Beta Signaling Activation.
Submit: New GeneRIF Correction See all GeneRIFs (53)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Bone mineral density quantitative trait locus 17
MedGen: C3714987 OMIM: 615311 GeneReviews: Not available
not available
Delayed puberty, self-limited
MedGen: C2874202 OMIM: 619613 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog
Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-hormone receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in activation of adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in bone remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in digestive tract development IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial cell proliferation involved in renal tubule morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in hair follicle development IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in intestinal stem cell homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in male genitalia development IEA
Inferred from Electronic Annotation
more info
  
involved_in metanephric glomerulus development IEA
Inferred from Electronic Annotation
more info
  
involved_in metanephric nephron tubule morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing G-protein coupled receptor 4
Names
G protein-coupled receptor 48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051818.2 RefSeqGene

    Range
    5000..111829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001346432.2 → NP_001333361.1  leucine-rich repeat-containing G-protein coupled receptor 4 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC090597, AC100771
    Consensus CDS
    CCDS86187.1
    UniProtKB/TrEMBL
    Q59ER8
    Related
    ENSP00000374508.4, ENST00000389858.4

  2. NM_018490.5 → NP_060960.2  leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_060960.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC090597, AC100771
    Consensus CDS
    CCDS31449.1
    UniProtKB/Swiss-Prot
    A6NCH3, G5E9B3, Q8N537, Q9BXB1, Q9NYD1
    UniProtKB/TrEMBL
    Q59ER8
    Related
    ENSP00000368516.4, ENST00000379214.9
    Conserved Domains (5) summary
    cd00116
    Location:44 → 239
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:59 → 82
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00001
    Location:556 → 801
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam01462
    Location:29 → 56
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:177 → 237
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    27365961..27472790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    27506453..27613276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BXB1.2 GenPept UniProtKB/Swiss-Prot:Q9BXB1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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