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SRGN serglycin [ Homo sapiens (human) ]

Gene ID: 5552, updated on 4-Jan-2025

Summary

Official Symbol
SRGNprovided by HGNC
Official Full Name
serglycinprovided by HGNC
Primary source
HGNC:HGNC:9361
See related
Ensembl:ENSG00000122862 MIM:177040; AllianceGenome:HGNC:9361
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPG; PRG; PRG1
Summary
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]
Expression
Biased expression in bone marrow (RPKM 1650.2), appendix (RPKM 289.1) and 5 other tissues See more
Orthologs
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Genomic context

See SRGN in Genome Data Viewer
Location:
10q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (69087603..69104811)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (69925937..69973238)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (70847359..70864567)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2425 Neighboring gene ACTB pseudogene 14 Neighboring gene uncharacterized LOC105378342 Neighboring gene Sharpr-MPRA regulatory region 5024 Neighboring gene MPRA-validated peak1005 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3475 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3477 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:70812477-70812978 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:70812979-70813478 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3484 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16959 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:70828777-70829328 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16968 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:70847990-70849189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2428 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:70884392-70884898 Neighboring gene VPS26 retromer complex component A Neighboring gene ribosomal protein S12 pseudogene 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3486 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:70949649-70949852 Neighboring gene Suv3 like RNA helicase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2429

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC9289, FLJ12930

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in T cell secretory granule organization  
involved_in apoptotic process  
involved_in biomineral tissue development  
involved_in granzyme-mediated programmed cell death signaling pathway PubMed 
involved_in maintenance of granzyme B location in T cell secretory granule  
involved_in maintenance of protease location in mast cell secretory granule  
involved_in mast cell secretory granule organization  
involved_in negative regulation of bone mineralization  
involved_in negative regulation of bone mineralization PubMed 
involved_in negative regulation of cytokine production  
involved_in protein processing  
involved_in secretory granule organization  
Component Evidence Code Pubs
located_in Golgi apparatus PubMed 
located_in cytolytic granule  
located_in extracellular matrix PubMed 
located_in extracellular region  
located_in extracellular space PubMed 
located_in mast cell granule  
located_in platelet alpha granule lumen  
is_active_in secretory granule  

General protein information

Preferred Names
serglycin
Names
hematopoetic proteoglycan core peptide
hematopoetic proteoglycan core protein
hematopoietic proteoglycan core protein
p.PG
platelet proteoglycan core protein
proteoglycan 1, secretory granule
proteoglycan protein core for mast cell secretory granule
secretory granule proteoglycan core peptide
secretory granule proteoglycan core protein
serglycin proteoglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321053.2NP_001307982.1  serglycin isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 3 encode isoform 1.
    Source sequence(s)
    AL442635, BC015516, BP363056
    Consensus CDS
    CCDS7285.1
    UniProtKB/Swiss-Prot
    B2R4L7, P10124, Q5VW06
    Conserved Domains (1) summary
    pfam04360
    Location:3150
    Serglycin
  2. NM_001321054.1NP_001307983.1  serglycin isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon in the coding region resulting in a frameshift compared to variant 1. The encoded isoform (2) is shorter, has a distinct N-terminus, and lacks a predicted signal peptide compared to isoform 1.
    Source sequence(s)
    AI347627, AL442635, BC015516, BP335278, BQ051861, CD677686
    UniProtKB/Swiss-Prot
    P10124
    Conserved Domains (1) summary
    pfam04360
    Location:2294
    Serglycin; Serglycin
  3. NM_002727.4NP_002718.2  serglycin isoform 1 precursor

    See identical proteins and their annotated locations for NP_002718.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an exon in the 5' UTR compared to variant 2. Both variants 1 and 3 encode isoform 1.
    Source sequence(s)
    BC015516, BG057351, BG548665, CA308463, CB110512
    Consensus CDS
    CCDS7285.1
    UniProtKB/Swiss-Prot
    B2R4L7, P10124, Q5VW06
    Related
    ENSP00000242465.3, ENST00000242465.4
    Conserved Domains (1) summary
    pfam04360
    Location:3150
    Serglycin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    69087603..69104811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    69925937..69973238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366246.1XP_054222221.1  serglycin isoform X1

  2. XM_054366247.1XP_054222222.1  serglycin isoform X1

  3. XM_054366248.1XP_054222223.1  serglycin isoform X1

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